公开(公告)号：KR1020100009221A

公开(公告)日：2010-01-27

申请号：KR1020080070007

申请日：2008-07-18

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  오상호 ,  노호식 ,  이지웅 ,  이제은 ,  육성훈 ,  진직

IPC: C07D453/04

CPC classification number: C07D453/04

Abstract: PURPOSE: A method for synthesizing bifunctional cinchona alkaloid catalyst is provided to ensure low toxicity, and chemical stability, and synthesize chiral hemiester having various structures in a short time. CONSTITUTION: A bifunctional cinchona alkaloid catalyst is denoted by chemical formula 1 or 2. A chiral hemiester is produced by reacting a prochiral or meso-cyclic acid anhydride with nucleophile in organic solvent under the presence of the bifunctional cinchona alkaloid catalyst. The nucleophile is alcohol or thiol. The organic solvent is dimethoxyethane, ethylvinyl ether, methyl t-butyl ether, diethyl ether, diisopropyl ether, tetra hydro furan or dioxane.

Abstract translation: 目的：提供一种合成双功能甜菜碱生物碱催化剂的方法，以确保低毒性和化学稳定性，并在短时间内合成具有各种结构的手性半酯。 构成：双功能金鸡纳生物碱催化剂由化学式1或2表示。手性半酯通过在双官能螯合生物碱催化剂存在下在有机溶剂中使前手性或内消旋酸酐与亲核试剂反应来制备。 亲核试剂是醇或硫醇。 有机溶剂为二甲氧基乙烷，乙基乙烯基醚，甲基叔丁基醚，乙醚，二异丙基醚，四氢呋喃或二恶烷。

公开(公告)号：KR101098335B1

公开(公告)日：2011-12-26

申请号：KR1020080070007

申请日：2008-07-18

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  오상호 ,  노호식 ,  이지웅 ,  이제은 ,  육성훈 ,  진직

IPC: C07D453/04

CPC classification number: C07D453/04

Abstract: R은에틸또는 -CH=CH이고; Ar은아릴기이다.

公开(公告)号：KR1020090108253A

公开(公告)日：2009-10-15

申请号：KR1020080033584

申请日：2008-04-11

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  노호식 ,  오상호 ,  진직 ,  이지웅

IPC: C07D403/06

Abstract: PURPOSE: A method for preparing chiral hemiesters through asymmetric ring opening reaction of meso-cyclic anhydrides is provided to ensure high value of industrial use and to reuse it by a basic acid-base distillation method. CONSTITUTION: A method for preparing chiral hemiesters through asymmetric ring opening reaction of meso-cyclic anhydrides comprises a step for reacting meso-cyclic anhydride with alcohol by using organic catalysts represented by chemical formula 1 or chemical formula 2 in the presence of an organic solvent. In the formulae, X is O or S and R is ethyl or vinyl. The chemical formula 1 has dihydro quinine or quinine as a starting material. The chemical formula 2 has dihydro quinine or quinine as a starting material.

Abstract translation: 目的：提供通过内消旋酸酐的不对称开环反应制备手性半酯的方法，以确保工业应用的高价值，并通过碱性酸碱蒸馏法再利用。 构成：通过内消旋酸酐的不对称开环反应制备手性半酯的方法包括在有机溶剂存在下使用由化学式1或化学式2表示的有机催化剂使内消旋环酐与醇反应的步骤。 在该式中，X是O或S，R是乙基或乙烯基。 化学式1具有二氢奎宁或奎宁作为原料。 化学式2具有二氢奎宁或奎宁作为起始原料。