公开(公告)号：KR1020090108253A

公开(公告)日：2009-10-15

申请号：KR1020080033584

申请日：2008-04-11

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  노호식 ,  오상호 ,  진직 ,  이지웅

IPC: C07D403/06

Abstract: PURPOSE: A method for preparing chiral hemiesters through asymmetric ring opening reaction of meso-cyclic anhydrides is provided to ensure high value of industrial use and to reuse it by a basic acid-base distillation method. CONSTITUTION: A method for preparing chiral hemiesters through asymmetric ring opening reaction of meso-cyclic anhydrides comprises a step for reacting meso-cyclic anhydride with alcohol by using organic catalysts represented by chemical formula 1 or chemical formula 2 in the presence of an organic solvent. In the formulae, X is O or S and R is ethyl or vinyl. The chemical formula 1 has dihydro quinine or quinine as a starting material. The chemical formula 2 has dihydro quinine or quinine as a starting material.

Abstract translation: 目的：提供通过内消旋酸酐的不对称开环反应制备手性半酯的方法，以确保工业应用的高价值，并通过碱性酸碱蒸馏法再利用。 构成：通过内消旋酸酐的不对称开环反应制备手性半酯的方法包括在有机溶剂存在下使用由化学式1或化学式2表示的有机催化剂使内消旋环酐与醇反应的步骤。 在该式中，X是O或S，R是乙基或乙烯基。 化学式1具有二氢奎宁或奎宁作为原料。 化学式2具有二氢奎宁或奎宁作为起始原料。

公开(公告)号：KR1020100056755A

公开(公告)日：2010-05-28

申请号：KR1020080115716

申请日：2008-11-20

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  육성훈 ,  오상호

IPC: C07D451/06 ,  C07D211/18

Abstract: PURPOSE: A method for manufacturing chiral hemiester using bifunctional organic catalys is provided to synthesize chiral compound which stereochemically or pharmaceutically useful. CONSTITUTION: A bifunctional organic catalyst is denoted by chemical formula 1 or 2. In chemical formula 1 or 2, Ar is 4-11 reduction aryl; R2-R8 are independently hydrogen, alkyl of 1-12 carbon atoms, alkenyl of 2-12 carbon atoms, alkenyl of 2-12 carbon atoms, alkoxy of 1-12 carbon atoms, or aryl of 4-11 reduction; and P is non-reactive polymer. The non-reactive polymer is polystyrene, polyethylene, or polypropylene. A chiral hemiester is prepared by reacting prochiral compound or meso-cyclic acid anhydride with nucleophile under the presence of a compound of chemical formula 1 or 2. The nucleophile is alcohol, thiol, or amine.

Abstract translation: 目的：提供使用双功能有机催化剂制备手性半酯的方法，以合成手性化合物，其立体化学或药学上可用。 构成：双官能有机催化剂由化学式1或2表示。在化学式1或2中，Ar为4-11个还原芳基; R2-R8独立地是氢，1-12个碳原子的烷基，2-12个碳原子的链烯基，2-12个碳原子的链烯基，1-12个碳原子的烷氧基，或者是4-11个碳原子的芳基; 而P是非反应性聚合物。 非反应性聚合物是聚苯乙烯，聚乙烯或聚丙烯。 在化学式为1或2的化合物存在下，使前手性化合物或内消旋环酸酐与亲核试剂反应制备手性半酯。亲核试剂是醇，硫醇或胺。

公开(公告)号：KR101073679B1

公开(公告)日：2011-10-14

申请号：KR1020080115716

申请日：2008-11-20

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  육성훈 ,  오상호

IPC: C07D451/06 ,  C07D211/18

Abstract: 본발명은고분자지지된이작용성유기촉매, 이의제조방법, 및이를이용한키랄성헤미에스터의제조방법에관한것으로서, 더욱상세하게는프로키랄화합물또는메소-고리산무수물의비대칭고리열림반응을수행하는데있어서, 고분자에이작용성유기촉매를담지하여높은거울상입체선택성을가지는키랄성헤미에스터를효과적으로제조하는방법에관한것이다.

公开(公告)号：KR1020100009221A

公开(公告)日：2010-01-27

申请号：KR1020080070007

申请日：2008-07-18

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  오상호 ,  노호식 ,  이지웅 ,  이제은 ,  육성훈 ,  진직

IPC: C07D453/04

CPC classification number: C07D453/04

Abstract: PURPOSE: A method for synthesizing bifunctional cinchona alkaloid catalyst is provided to ensure low toxicity, and chemical stability, and synthesize chiral hemiester having various structures in a short time. CONSTITUTION: A bifunctional cinchona alkaloid catalyst is denoted by chemical formula 1 or 2. A chiral hemiester is produced by reacting a prochiral or meso-cyclic acid anhydride with nucleophile in organic solvent under the presence of the bifunctional cinchona alkaloid catalyst. The nucleophile is alcohol or thiol. The organic solvent is dimethoxyethane, ethylvinyl ether, methyl t-butyl ether, diethyl ether, diisopropyl ether, tetra hydro furan or dioxane.

Abstract translation: 目的：提供一种合成双功能甜菜碱生物碱催化剂的方法，以确保低毒性和化学稳定性，并在短时间内合成具有各种结构的手性半酯。 构成：双功能金鸡纳生物碱催化剂由化学式1或2表示。手性半酯通过在双官能螯合生物碱催化剂存在下在有机溶剂中使前手性或内消旋酸酐与亲核试剂反应来制备。 亲核试剂是醇或硫醇。 有机溶剂为二甲氧基乙烷，乙基乙烯基醚，甲基叔丁基醚，乙醚，二异丙基醚，四氢呋喃或二恶烷。

公开(公告)号：KR101098335B1

公开(公告)日：2011-12-26

申请号：KR1020080070007

申请日：2008-07-18

Applicant: 성균관대학교산학협력단

Inventor： 송충의 ,  오상호 ,  노호식 ,  이지웅 ,  이제은 ,  육성훈 ,  진직

IPC: C07D453/04

CPC classification number: C07D453/04

Abstract: R은에틸또는 -CH=CH이고; Ar은아릴기이다.