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1.发明授权신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 有权基于Cinchona的双功能有机催化剂和通过使用其的内消旋酸酐的不对称开环反应制备手性半胱氨酸的方法
公开(公告)号：KR101098335B1
公开(公告)日：2011-12-26
申请号：KR1020080070007
申请日：2008-07-18
Applicant: 성균관대학교산학협력단
IPC: C07D453/04
CPC classification number: C07D453/04
Abstract: R은에틸또는 -CH=CH이고; Ar은아릴기이다.
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2.发明公开신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 有权基于CINCHONA的双组分有机组合物和通过不对称开环反应的MESO循环酸的反应制备CHIRAL HEMIESTERS的方法
公开(公告)号：KR1020100009221A
公开(公告)日：2010-01-27
申请号：KR1020080070007
申请日：2008-07-18
Applicant: 성균관대학교산학협력단
IPC: C07D453/04
CPC classification number: C07D453/04
Abstract: PURPOSE: A method for synthesizing bifunctional cinchona alkaloid catalyst is provided to ensure low toxicity, and chemical stability, and synthesize chiral hemiester having various structures in a short time. CONSTITUTION: A bifunctional cinchona alkaloid catalyst is denoted by chemical formula 1 or 2. A chiral hemiester is produced by reacting a prochiral or meso-cyclic acid anhydride with nucleophile in organic solvent under the presence of the bifunctional cinchona alkaloid catalyst. The nucleophile is alcohol or thiol. The organic solvent is dimethoxyethane, ethylvinyl ether, methyl t-butyl ether, diethyl ether, diisopropyl ether, tetra hydro furan or dioxane.
Abstract translation: 目的：提供一种合成双功能甜菜碱生物碱催化剂的方法，以确保低毒性和化学稳定性，并在短时间内合成具有各种结构的手性半酯。 构成：双功能金鸡纳生物碱催化剂由化学式1或2表示。手性半酯通过在双官能螯合生物碱催化剂存在下在有机溶剂中使前手性或内消旋酸酐与亲核试剂反应来制备。 亲核试剂是醇或硫醇。 有机溶剂为二甲氧基乙烷，乙基乙烯基醚，甲基叔丁基醚，乙醚，二异丙基醚，四氢呋喃或二恶烷。
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