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公开(公告)号：KR1020150114445A
公开(公告)日：2015-10-12
申请号：KR1020150049851
申请日：2015-04-08
Applicant: 성균관대학교산학협력단
Abstract: 키랄성알코올화합물의제조방법이개시된다. 키랄성알코올화합물을제조하기위하여키랄촉매화합물의존재하에라세믹알코올화합물또는메조알코올화합물과실릴화제를입체선택적으로반응시킬수 있고, 이경우키랄촉매화합물로는염기부분인올리고에틸렌글라이콜작용기와산성부분인바이놀유도체의하이드록시작용기를포함하는올리고에틸렌글라이콜이유도체화된화합물을사용할수 있다.
Abstract translation: 公开了一种制造手性醇化合物的方法。 在手性催化剂化合物的存在下，外消旋醇化合物或内消旋醇化合物和甲硅烷基化剂可以以立体选择性方式反应，制造手性醇化合物。 在这种情况下，作为手性催化剂化合物，可以使用以包含低聚乙二醇官能团为基础的低聚乙二醇衍生的化合物和二醇衍生物的羟基官能团作为酸性部分。
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2.发明公开입체선택성이 우수한 이작용성 유기 키랄 촉매 화합물, 이의 제조 방법 및 이를 이용한 아즈락톤으로부터의 키랄 아미노산 제조방법 有权高选择性双官能团，其制备方法，以及使用该化合物从AZLACTONES制备乳酸氨基酸的方法
公开(公告)号：KR1020100122449A
公开(公告)日：2010-11-22
申请号：KR1020100043432
申请日：2010-05-10
Applicant: 성균관대학교산학협력단
IPC: C07D403/14 , C07D213/30
Abstract: PURPOSE: A method for preparing chiral amino acid ester having high stereoselectivity is provided to economically and simply produce N-acyl amino acid ester of highly optical selectivity. CONSTITUTION: A bifunctional organic chiral catalyst compound is denoted by chemical formula 1. A method for preparing the bifunctional chiral organic catalyst comprises a step of reacting amine with 3,4-alkoxy-3-cyclobutene-1,2-dione derivative. A chiral N-acyl amino acid ester is prepared from azlactone by reacting racemic azlactone, (S)-azlactone or (R)-azlactoen with nucleophile under the presence of organic solvent.
Abstract translation: 目的：提供具有高立体选择性的手性氨基酸酯的制备方法，以经济地简单地生产具有高光学选择性的N-酰基氨基酸酯。 构成：双官能有机手性催化剂化合物由化学式1表示。制备双功能手性有机催化剂的方法包括使胺与3,4-烷氧基-3-环丁烯-1,2-二酮衍生物反应的步骤。 在有机溶剂存在下，通过外消旋吖内酯，（S） - 吖内酯或（R） - az乳酸与亲核试剂反应，由吖内酯制备手性N-酰基氨基酸酯。
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3.发明公开신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 有权基于CINCHONA的双组分有机组合物和通过不对称开环反应的MESO循环酸的反应制备CHIRAL HEMIESTERS的方法
公开(公告)号：KR1020100009221A
公开(公告)日：2010-01-27
申请号：KR1020080070007
申请日：2008-07-18
Applicant: 성균관대학교산학협력단
IPC: C07D453/04
CPC classification number: C07D453/04
Abstract: PURPOSE: A method for synthesizing bifunctional cinchona alkaloid catalyst is provided to ensure low toxicity, and chemical stability, and synthesize chiral hemiester having various structures in a short time. CONSTITUTION: A bifunctional cinchona alkaloid catalyst is denoted by chemical formula 1 or 2. A chiral hemiester is produced by reacting a prochiral or meso-cyclic acid anhydride with nucleophile in organic solvent under the presence of the bifunctional cinchona alkaloid catalyst. The nucleophile is alcohol or thiol. The organic solvent is dimethoxyethane, ethylvinyl ether, methyl t-butyl ether, diethyl ether, diisopropyl ether, tetra hydro furan or dioxane.
Abstract translation: 目的：提供一种合成双功能甜菜碱生物碱催化剂的方法，以确保低毒性和化学稳定性，并在短时间内合成具有各种结构的手性半酯。 构成：双功能金鸡纳生物碱催化剂由化学式1或2表示。手性半酯通过在双官能螯合生物碱催化剂存在下在有机溶剂中使前手性或内消旋酸酐与亲核试剂反应来制备。 亲核试剂是醇或硫醇。 有机溶剂为二甲氧基乙烷，乙基乙烯基醚，甲基叔丁基醚，乙醚，二异丙基醚，四氢呋喃或二恶烷。
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公开(公告)号：KR1020090058239A
公开(公告)日：2009-06-09
申请号：KR1020070124926
申请日：2007-12-04
Applicant: 성균관대학교산학협력단
IPC: C07C5/10
Abstract: A hydrogenation method of aromatic compounds is provided to hydrogenate an aromatic compound in a condition of normal temperature and atmospheric pressure, to ensure fast reaction rate, to reduce side reactions and used amount of the metal catalyst. A hydrogenation method of aromatic compounds comprises the steps of: (i) putting an ionic salt Lewis acid catalyst of chemical formula 1: [A^+][M_(m+n)X_(x+y)^-], metal and a support catalyst in an aromatic compound and then stirring the materials under a hydrogen gas atmosphere; (ii) separating and organic layer containing a hydrogenated aromatic compound and an aqueous layer by adding an organic solvent to the product; and (iii) evaporating solvent by drying the separated materials. In chemical formula 1, A is an organic cation from an organic salt; and [M_(m+n)X_(x+y)^-] is an anion capable of forming salts with A.
Abstract translation: 提供芳族化合物的氢化方法，以在常温常压条件下氢化芳族化合物，以确保快速的反应速率，减少副反应和金属催化剂的使用量。 芳族化合物的氢化方法包括以下步骤：（i）将化学式1的离子盐路易斯酸催化剂：[A ^ +] [M_（m + n）X_（x + y）] - 芳族化合物中的载体催化剂，然后在氢气气氛下搅拌该物质; （ii）通过向产物中加入有机溶剂而分离含有氢化芳族化合物和水层的有机层; 和（iii）通过干燥分离的材料蒸发溶剂。 在化学式1中，A是有机盐的有机阳离子; 和[M_（m + n）X_（x + y）^ - ]是能够与A形成盐的阴离子。
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公开(公告)号：KR1020170036955A
公开(公告)日：2017-04-04
申请号：KR1020150135799
申请日：2015-09-24
Applicant: 성균관대학교산학협력단
IPC: F16K11/06 , F16K11/074 , F16K31/60 , F16K11/00 , E03C1/04
Abstract: 본발명은온수조절이용이한수전카트리지에관한것으로서, 본발명에따른수전카트리지는하우징; 상기하우징의내부에위치하며, 그리고냉수토출구, 온수토출구및 혼합수배출구를구비한고정디스크; 상기고정디스크에접하는가동디스크를포함하는수전카트리지에서, 상기고정디스크에접하는상기가동디스크의일측에홈이위치하며, 상기홈은단면형상이상기가동디스크의일측의중심에서소정의반지름을갖는원 형상인제1홈; 및단면의형상이반원형상인제2홈을포함하는것을특징으로한다. 이에의하여, 온수와냉수가적정하게혼합될수 있는범위가넓은, 즉급격한온도변화를최소화할수 있는온수조절이가능한수전카트리지가제공된다.
Abstract translation: 技术领域本发明涉及一种在使用热水控制之前的筒， 固定盘，位于所述壳体内并具有冷水排出口，热水排出口和混合水排出口; 在包括与固定盘接触的可移动盘的容纳盒中，凹槽位于可移动盘的与固定盘接触的一侧上，并且凹槽是从截面的一侧的中心起具有预定半径的圆形， Inje 1槽; 并且第二个凹槽的横截面形状是半圆形。 由此，提供了一种能够充分混合热水和冷水的水容器盒，即能够调节热水以最小化突然的温度变化。
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Patent Agency Ranking6.发明公开이작용성 화합물을 용매로 사용한 친핵성 치환반응에 따른 유기플루오로 화합물의 제조방법 및 친핵성 치환반응 생성물의 제조방법 无效有机氟化合物的制备方法，使用双官能化合物作为溶剂获得的产物获得的产物的制备方法
公开(公告)号：KR1020100117221A
公开(公告)日：2010-11-03
申请号：KR1020090035850
申请日：2009-04-24
Applicant: 성균관대학교산학협력단
IPC: C07C41/22 , C07C43/225 , C07C43/13
Abstract: PURPOSE: A fabricating method of an organic fluoro compound with the high yield, and a manufacturing method of a nucleophilic displacement product are provided to improve the speed of the displacement reaction using a bi-functional compound as a solvent. CONSTITUTION: A manufacturing method of a nucleophilic displacement product comprises a step of reacting alkyl halide or alkyl sulfonate, with metal salt or ammonium salt inside an organic solvent. The organic solvent is a bi-functional compound marked with chemical formula 1. In the chemical formula 1, R1, R2, and R3 are hydrogen or a C1~C10 alkyl group. The metal salt is selected from the group consisting of lithium salt, sodium salt, potassium salt, rubidium, and cesium salt.
Abstract translation: 目的：提供高收率的有机氟化合物的制造方法和亲核置换产物的制造方法，以提高使用双官能化合物作为溶剂的置换反应的速度。 构成：亲核置换产物的制造方法包括使烷基卤化物或烷基磺酸盐与有机溶剂内的金属盐或铵盐反应的步骤。 有机溶剂是用化学式1表示的双功能化合物。在化学式1中，R1，R2和R3是氢或C1〜C10烷基。 金属盐选自锂盐，钠盐，钾盐，铷和铯盐。
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7.发明公开메소-고리 산무수물의 비대칭 고리 열림 반응을 통한입체선택적인 헤미에스터의 제조방법 无效通过不对称开环反应MESO-CYCLIC ANHYDRIDES制备CHIRAL HEMIESTERS的方法
公开(公告)号：KR1020090108253A
公开(公告)日：2009-10-15
申请号：KR1020080033584
申请日：2008-04-11
Applicant: 성균관대학교산학협력단
IPC: C07D403/06
Abstract: PURPOSE: A method for preparing chiral hemiesters through asymmetric ring opening reaction of meso-cyclic anhydrides is provided to ensure high value of industrial use and to reuse it by a basic acid-base distillation method. CONSTITUTION: A method for preparing chiral hemiesters through asymmetric ring opening reaction of meso-cyclic anhydrides comprises a step for reacting meso-cyclic anhydride with alcohol by using organic catalysts represented by chemical formula 1 or chemical formula 2 in the presence of an organic solvent. In the formulae, X is O or S and R is ethyl or vinyl. The chemical formula 1 has dihydro quinine or quinine as a starting material. The chemical formula 2 has dihydro quinine or quinine as a starting material.
Abstract translation: 目的：提供通过内消旋酸酐的不对称开环反应制备手性半酯的方法，以确保工业应用的高价值，并通过碱性酸碱蒸馏法再利用。 构成：通过内消旋酸酐的不对称开环反应制备手性半酯的方法包括在有机溶剂存在下使用由化学式1或化学式2表示的有机催化剂使内消旋环酐与醇反应的步骤。 在该式中，X是O或S，R是乙基或乙烯基。 化学式1具有二氢奎宁或奎宁作为原料。 化学式2具有二氢奎宁或奎宁作为起始原料。
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公开(公告)号：KR101663863B1
公开(公告)日：2016-10-07
申请号：KR1020140038403
申请日：2014-04-01
Applicant: 성균관대학교산학협력단
Abstract: 키랄성알코올화합물의제조방법이개시된다. 키랄성알코올화합물을제조하기위하여키랄촉매화합물의존재하에라세믹알코올화합물또는메조알코올화합물과실릴화제를입체선택적으로반응시킬수 있고, 이경우키랄촉매화합물로는염기부분인올리고에틸렌글라이콜작용기와산성부분인바이놀유도체의하이드록시작용기를포함하는올리고에틸렌글라이콜이유도체화된화합물을사용할수 있다.
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9.发明授权입체선택성이 우수한 이작용성 유기 키랄 촉매 화합물, 이의 제조 방법 및 이를 이용한 아즈락톤으로부터의 키랄 아미노산 제조방법 有权高选择性双官能团，其制备方法，以及使用该化合物从AZLACTONES制备乳酸氨基酸的方法
公开(公告)号：KR101163994B1
公开(公告)日：2012-07-18
申请号：KR1020100043432
申请日：2010-05-10
Applicant: 성균관대학교산학협력단
IPC: C07D403/14 , C07D213/30
Abstract: 본 발명은 라세믹 또는 키랄 아즈락톤으로부터 높은 입체선택성을 갖는 키랄 아미노산 에스터를 수득하는 방법을 제공하며, 여기에 사용되는 유도체화된 이작용성 유기 키랄 촉매 화합물과 그의 제조방법을 제공한다.
현재까지 알려진 제조방법에 따르면, 높은 거울상 입체 선택성을 가지는 N- 아실 아미노산 에스터를 얻기 위하여 저온에서 장시간 반응을 수행해야 한다는 문제점이 있을뿐만 아니라, 수득되는 화합물의 광학 선택성 또한 공업화에 적용시키기에 부족하였다. 본 발명에 따른 촉매 화합물은 신코나 알칼로이드로부터 쉽게 합성이 가능하며, 매우 경제적이며 간편한 방법으로 높은 광학선택성을 갖는 N-아실 아미노산 에스터를 수득할 수 있을 뿐 아니라 자연에 존재하지 않는 (R)-형태의 다양한 N-아실 아미노산 에스터도 높은 광학 순도로 제조할 수 있어 공업화에 유용한 기술로 활용될 것이 예상된다.-
10.发明授权이작용성 비스 신코나 알칼로이드 티오우레아 유기 키랄 촉매 화합물을 이용한 아즈락톤으로부터의 키랄 아미노산 제조방법 有权使用双官能二硝基苯甲酸硫酸酯有机催化剂从AZLACTONES制备乳酸氨基酸的方法
公开(公告)号：KR101130818B1
公开(公告)日：2012-04-12
申请号：KR1020090063047
申请日：2009-07-10
Applicant: 성균관대학교산학협력단
IPC: C07D403/14
Abstract: PURPOSE: A bifunctional bis-cinchona alkaloid thiourea organic chiral catalyst compound and a method for preparing the same are provided to obtain (R)-type N-acyl amino acid ester of highly optical purity. CONSTITUTION: A bifunctional bis-cinchona alkaloid thiourea organic chiral catalyst compound is denoted by chemical formula 1. In chemical formula 1, R is ethyl group or -CH=CH_2. The bifunctional organic chiral catalyst is obtained by reacting amine with carbothio diimidazole. The amine is obtained from cinchona alkaloid by epimerization. A chiral N-acyl amino acid ester is obtained by reacting N-acyl amino acid, racemic azlactone, (S)-azlactone or (R)-azlactone with neucleophile under the presence of bifunctional chiral organic catalyst. The neucleophile is alcohol or thiol.
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