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公开(公告)号：KR1020080060777A
公开(公告)日：2008-07-02
申请号：KR1020060135267
申请日：2006-12-27
Applicant: 재단법인서울대학교산학협력재단
Abstract: An antibacterial amide derivative is provided to interrupt communication between bacteria as a quorum sensing antagonist, so that the compound is useful for preventing the biofilm formation by bacteria and disease occurrence. An antibacterial amide derivative is represented by the formula(1) or formula(2), wherein R1 and R2 are each independently aromatic hydrocarbon group or aromatic hydrocarbon group having hetero atom. The biofilm formation is prevented by contacting the antibacterial amide derivative represented by the formula(1) or formula(2) with bacteria including gram negative bacteria.
Abstract translation: 提供抗细菌酰胺衍生物以中断细菌作为群体感应拮抗剂之间的连通，使得该化合物可用于防止细菌生物膜形成和疾病发生。 抗菌酰胺衍生物由式（1）或式（2）表示，其中R 1和R 2各自独立地为具有杂原子的芳族烃基或芳族烃基。 通过使由式（1）或式（2）表示的抗菌酰胺衍生物与包括革兰氏阴性细菌的细菌接触来防止生物膜形成。
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公开(公告)号：KR100841333B1
公开(公告)日：2008-06-25
申请号：KR1020060115885
申请日：2006-11-22
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/32 , C07D401/12
Abstract: 항균성을 지니는 동시에 쿼럼센싱 길항제로 기능을 하는 항균성 호모세린 락톤 유도체 및 이를 이용한 미생물의 제거 방법에서, 호모세린 락톤 유도체는 세균들 간의 의사소통을 방해하는 호모세린 락톤 잔기와 함께, 그람 양성균과 그람 음성균에 대하여 항균성을 지니는 치환기를 포함한다. 이에 따라 항균성 호모세린 락톤 유도체는 세균들에 대하여 우수한 항균력을 지니는 동시에, 생물막의 형성과 번식을 효과적으로 차단할 수 있다.
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公开(公告)号：KR1020080046434A
公开(公告)日：2008-05-27
申请号：KR1020060115885
申请日：2006-11-22
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/32 , C07D401/12
Abstract: An antibacterial homoserine lactone derivative is provided to act as a quorum sensing antagonist for interrupting communications between microorganisms, thereby blocking a biofilm by the microorganisms effectively and preventing bacteria from propagating. An antibacterial homoserine lactone derivative is represented by a formula(1) or (2), wherein R1 is an aromatic hydrocarbon including N or an aromatic hydrocarbon including amino or nitro as a substituent; and R2 is a non-substituted aromatic hydrocarbon or an aromatic hydrocarbon including C1-4 alkyl or amino as a substituent. A method for removing microorganism comprises a step of contacting the microorganism with the antibacterial homoserine lactone derivative, wherein the microorganism includes Gram positive bacillus or Gram negative bacillus.
Abstract translation: 提供抗菌高丝氨酸内酯衍生物作为中断微生物之间的通讯的群体感知拮抗剂，从而有效地阻止微生物的生物膜并防止细菌繁殖。 抗菌高丝氨酸内酯衍生物由式（1）或（2）表示，其中R1是包括N或包含氨基或硝基作为取代基的芳族烃的芳烃; R2是非取代芳香烃或包括C 1-4烷基或氨基作为取代基的芳烃。 一种除去微生物的方法包括使微生物与抗菌高丝氨酸内酯衍生物接触的步骤，其中微生物包括革兰氏阳性杆菌或革兰氏阴性杆菌。
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公开(公告)号：KR100832565B1
公开(公告)日：2008-05-26
申请号：KR1020060135260
申请日：2006-12-27
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/46
Abstract: An antibacterial furanone derivative is provided to function as a quorum sensing antagonist, which interrupts communication among bacteria due to a chemical structure similar to a material used for the communication of the bacteria, thereby being used for preventing formation of a biofilm. A method for preventing formation of a biofilm comprises a step of contacting an antibacterial furanone derivative represented by a formula(1)(wherein R is C1-10 alkyl or C1-10 haloalkyl) with microorganism to inhibit the formation of the biofilm, wherein the antibacterial furanone derivative is represented by a formula(2), (3), (4), (5), (6), (7) or (8) and the microorganism includes Gram negative bacillus.
Abstract translation: 提供抗菌呋喃酮衍生物作为法定感测拮抗剂，其由于与用于细菌通信的材料类似的化学结构而中断细菌之间的交流，从而用于防止生物膜的形成。 防止生物膜形成的方法包括使由式（1）表示的抗菌呋喃酮衍生物（其中R为C 1-10烷基或C 1-10卤代烷基）与微生物接触以抑制生物膜形成的步骤，其中 抗菌呋喃酮衍生物由式（2），（3），（4），（5），（6），（7）或（8）表示，微生物包括革兰氏阴性杆菌。
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Patent Agency Ranking
公开(公告)号：KR100761815B1
公开(公告)日：2007-10-04
申请号：KR1020060115494
申请日：2006-11-21
Applicant: 재단법인서울대학교산학협력재단
Abstract: An anti-biofouling polymer is provided to prevent adhesion of microorganisms stably and continuously by virtue of a low surface energy derived from a high surface density of fluorine atoms. An anti-biofouling polymer is represented by formula 1, wherein X represents a halogen atom, Rf represents a C1-C20 fluoroalkyl group, p is a number of 0.50-0.99, l is an integer of 10-10,000, and each of m and n is an integer of 1-4. The anti-biofouling polymer has a number average molecular weight of 1000-50,000 and a polydispersity index of 1.0-2.0. The anti-biofouling polymer is obtained by reacting a haloalkylene oxide polymer with a C1-C20 fluorinated alkanethiol of CF3(CF2)x(CH2)ySH.
Abstract translation: 提供了抗生物污损聚合物，以通过源自氟原子的高表面密度的低表面能来稳定且连续地粘附微生物。 抗生物污垢聚合物由式1表示，其中X表示卤素原子，Rf表示C1-C20氟代烷基，p表示数为0.50-0.99，l为10-10,000的整数，m和 n为1-4的整数。 抗生物结垢聚合物的数均分子量为1000-50,000，多分散指数为1.0-2.0。 通过使卤代环氧烷聚合物与CF 3（CF 2）x（CH 2）y SH的C 1 -C 20氟化烷硫醇反应获得抗生物污损聚合物。
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公开(公告)号：KR100841289B1
公开(公告)日：2008-06-25
申请号：KR1020060120182
申请日：2006-11-30
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/30 , A61P31/04
Abstract: 쿼럼센싱 길항제로 기능을 하는 항균성 호모세린 락톤 유도체 및 이를 이용한 생물막의 형성 방지 방법에서, 호모세린 락톤 유도체는 호모세린 락톤의 말단에 세 번째 탄소에 수산기가 치환된 알킬설포닐기를 포함하고 있어서, 미생물의 자기유도자(autoinducer)와 경쟁하여 유전자의 발현을 억제한다. 이에 따라 항균성 호모세린 락톤 유도체는 미생물의 번식과 생물막의 형성을 효과적으로 차단할 수 있다.
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公开(公告)号：KR100841294B1
公开(公告)日：2008-06-25
申请号：KR1020060121650
申请日：2006-12-04
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/30 , A61P31/04
CPC classification number: C07D405/12 , C07D307/32
Abstract: 쿼럼센싱 길항제로 기능을 하는 항균성 호모세린 락톤 유도체 및 이를 이용한 생물막의 형성 방지 방법에서, 항균성 호모세린 락톤 유도체는 호모세린 락톤 잔기와 설파닐 에타노일기(sulfanyl ethanoyl group)를 포함한다. 항균성 호모세린 락톤 유도체는 세균들이 의사소통을 위하여 신호전달 물질로 이용하는 화합물과 유사한 화학적 구조를 가지며, 세균들 간의 의사소통을 방해하는 쿼럼센싱 길항제(quorum sensing antagonist)로 기능을 한다. 이에 따라 항균성 호모세린 락톤 유도체는 미생물의 번식과 생물막의 형성을 효과적으로 차단할 수 있다.
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公开(公告)号：KR1020080050844A
公开(公告)日：2008-06-10
申请号：KR1020060121650
申请日：2006-12-04
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/30 , A61P31/04
CPC classification number: C07D405/12 , C07D307/32
Abstract: A homoserine lactone derivative is provided to inhibit quorum sensing, and prevent formation of biofilm and propagation of microorganisms by inhibiting gene expression of microorganisms, so that the compound is useful for inhibiting bacterial infection and biofilm formation in various life articles and medicinal instruments. A homoserine lactone derivative represented by the formula(1) or formula(2) is useful as a quorum sensing antagonist, wherein n is an integer from 0 to 10; R1 is hydrogen atom, carboxy group, aromatic hydrocarbon group containing nitrogen as a hetero atom or C1-C10 carboxyalkylthio group; R2 is aromatic hydrocarbon group or C1-C10 carboxyalkylthio group. The formation of biofilm of a microorganism such as Gram negative bacterium or Vibrio fischeri is prevented by contacting the homoserine lactone derivative represented by the formula(1) or formula(2) with the microorganism.
Abstract translation: 提供高丝氨酸内酯衍生物以抑制群体感应，并通过抑制微生物的基因表达来防止生物膜的形成和微生物的繁殖，使得该化合物可用于抑制各种生命制品和药物仪器中的细菌感染和生物膜形成。 由式（1）或式（2）表示的高丝氨酸内酯衍生物可用作群体感应拮抗剂，其中n为0至10的整数; R1是氢原子，羧基，含有氮原子的芳香族烃基或C1-C10羧烷基硫基; R2是芳族烃基或C1-C10羧烷基硫基。 通过使由式（1）或式（2）表示的高丝氨酸内酯衍生物与微生物接触，可以防止微生物如革兰氏阴性细菌或弧菌的生物膜的形成。
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公开(公告)号：KR1020080049527A
公开(公告)日：2008-06-04
申请号：KR1020060120182
申请日：2006-11-30
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D307/30 , A61P31/04
Abstract: An antibacterial homoserine lactone derivative is provided to show excellent capability as a quorum sensing antagonist, thereby effectively blocking formation of a bio-film and inhibiting propagation of bacteria. An antibacterial homoserine lactone derivative is represented by a formula(1), wherein X is OH or thiol; n is an integer from 1 to 10; and R is H, halogen, thiol, C1-10 alkoxy, C1-10 alkylamino, C1-10 cycloalkylamino, C1-10 hydroxyalkylamino, morpholino, piperazinyl or hydroxyalkyl piperazinyl. A method for preventing formation of a biofilm comprises a step of contacting the homoserine lactone derivative with microorganism such as Gram negative bacteria.
Abstract translation: 提供抗菌高丝氨酸内酯衍生物以显示出优异的作为群体感应拮抗剂的能力，从而有效阻断生物膜的形成并抑制细菌繁殖。 抗菌高丝氨酸内酯衍生物由式（1）表示，其中X是OH或硫醇; n是1至10的整数; 且R为H，卤素，硫醇，C 1-10烷氧基，C 1-10烷基氨基，C 1-10环烷基氨基，C 1-10羟烷基氨基，吗啉代，哌嗪基或羟基烷基哌嗪基。 防止生物膜形成的方法包括将高丝氨酸内酯衍生物与革兰氏阴性细菌等微生物接触的步骤。
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