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1.发明授权간세포 보호활성을 나타내는 비자나무의 수피로부터분리한 다이벤질부틸락톤 리그난 유도체 및 이를유효성분으로 함유하는 간세포 보호 및 간 질환 치료용조성물 失效간세포보호활성을나타내는비자나무의수피로부터분리한다이벤질부틸락톤리그난유도체및이를유효성분으로함유하는간세포보호및간질환치료용조성물
公开(公告)号：KR100459088B1
公开(公告)日：2004-12-03
申请号：KR1020010061217
申请日：2001-10-04
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K31/365
Abstract: PURPOSE: A pharmaceutical composition containing a dibenzylbutyllactone lignan derivative separated from the bark of Torreya nucifera(L.) Sieb. et Zucc. as an active component is provided. The dibenzylbutyllactone lignan derivative protects a liver cell from toxicity induced by carbon tetrachloride and galactosamine and effectively inhibits the proliferation of HSC2 liver. It is, therefore, effectively used in protection of the liver cell and treatment of acute, chronic liver disease. CONSTITUTION: The pharmaceutical composition contains a dibenzylbutyllactone lignan derivative represented by the formula(1) and a pharmaceutically acceptable salt. In formula, R1, R2, R3, R4 and R5 are each independently hydroxyl or methoxy groups. The dibenzylbutyllactone lignan derivative is prepared by extracting the bark of Torreya nucifera in lower alcohol at 20 to 80deg.C for 1 to 3hr, fractioning the extract with dichloromethane and then performing column chromatography.
Abstract translation: 用途：含有从Torreya nucifera（L。）Sieb的树皮中分离出的二苄基丁内酯木脂素衍生物的药物组合物。 et Zucc。 作为活性组分提供。 二苄基丁内酯木脂素衍生物保护肝细胞免受四氯化碳和半乳糖胺诱导的毒性，并有效抑制HSC2肝脏的增殖。 因此，它有效地用于保护肝细胞和治疗急性，慢性肝病。 组成：药物组合物含有由式（1）表示的二苄基丁内酯木脂素衍生物和药学上可接受的盐。 式中，R 1，R 2，R 3，R 4和R 5各自独立地为羟基或甲氧基。 二苄基丁内酯木脂素衍生物的制备方法是在20-80℃的低级醇中提取Torreya nucifera的树皮1至3小时，用二氯甲烷分级提取物，然后进行柱层析。
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2.发明授权폴리우레탄 폼에서 발생하는 휘발성 유기화합물을 저감시키는 항산화 발효미생물 제재 및 이를 포함하는 폴리우레탄 폼 失效抗氧化剂发生微生物代谢减少挥发性有机化合物从聚氨酯泡沫和含有其的尿素泡沫
公开(公告)号：KR100802578B1
公开(公告)日：2008-02-13
申请号：KR1020060042034
申请日：2006-05-10
Applicant: 현대다이모스(주) , 재단법인서울대학교산학협력재단
CPC classification number: C12N1/20 , C08G2101/00 , C08G2290/00 , C08L75/04 , C12N1/16 , C08L2666/28
Abstract: 본 발명은 항산화발효미생물 제재 및 이를 포함하는 폴리우레탄 폼에 관한 것으로서, 항산화발효미생물 제재는 폴리우레탄 폼에서 발생하는 휘발성유기화합물을 저감시키는 효과 및 항균효과가 있는 물질을 생성하여 항균효과를 나타낼 수 있다. 따라서, 본 발명의 항산화발효미생물을 포함하는 폴리우레탄 폼이 자동차 내장재로 사용될 때 새차 증후군을 일으키는 유해물질로부터 인체를 보호하는 작용을 할 수 있다.
항산화발효미생물, 폴리우레탄 폼, 휘발성유기화합물-
公开(公告)号：KR100470150B1
公开(公告)日：2005-02-05
申请号：KR1020010074251
申请日：2001-11-27
Applicant: 재단법인서울대학교산학협력재단
IPC: C07C43/275
Abstract: PURPOSE: A meso-dihydroguaiaretic acid derivative, an inhibitor of the liver fibrosis containing the derivative, a Machilus thunbergii Sieb et Zucc. extract for inhibiting the liver fibrosis and a medical composition containing the extract for inhibiting the liver fibrosis are provided, wherein the derivative shows an excellent activity inhibiting the liver fibrosis. CONSTITUTION: The meso-dihydroguaiaretic acid derivative is represented by the formula 1, wherein R1 and R2 are independently H or an alkyl group of C1-C4; and R3 and R4 are independently an alkyl group of C1-C4 (but meso-dihydroguaiaretic acid is excluded). The Machilus thunbergii Sieb et Zucc. extract is obtained by extracting Machilus thunbergii Sieb et Zucc. with an alcohol of C1-C4, and optionally suspending it with water; fractionating the extracted one with CH2Cl2; and separating the obtained CH2Cl2 fraction by column chromatography.
Abstract translation: 目的：内消旋二氢愈创木酸衍生物，含有该衍生物的肝纤维化抑制剂，Machilus thunbergii Sieb et Zucc。 提供了用于抑制肝纤维化的提取物和含有用于抑制肝纤维化的提取物的药物组合物，其中所述衍生物显示出抑制肝纤维化的优异活性。 构成：内消旋二氢愈创木酸衍生物由式1表示，其中R1和R2独立地为H或C1-C4的烷基; 并且R3和R4独立地为C1-C4的烷基（但不包括内消旋二氢愈创木酸）。 Machilus thunbergii Sieb et Zucc。 提取物通过提取Machilus thunbergii Sieb et Zucc获得。 与C1-C4的醇反应，并任选将其悬浮于水中; 用CH 2 Cl 2分馏萃取液; 并通过柱色谱分离所得的CH 2 Cl 2馏分。
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Patent Agency Ranking4.发明公开폴리우레탄 폼에서 발생하는 휘발성 유기화합물을 저감시키는 항산화 발효미생물 제재 및 이를 포함하는 폴리우레탄 폼 失效抗氧化剂发生微生物代谢减少挥发性有机化合物从聚氨酯泡沫和含有其的尿素泡沫
公开(公告)号：KR1020070109276A
公开(公告)日：2007-11-15
申请号：KR1020060042034
申请日：2006-05-10
Applicant: 현대다이모스(주) , 재단법인서울대학교산학협력재단
CPC classification number: C12N1/20 , C08G2101/00 , C08G2290/00 , C08L75/04 , C12N1/16 , C08L2666/28
Abstract: An antioxidative fermenting microorganism agent is provided to reduce volatile organic compounds generated from polyurethane foam and generate antibacterial material. And polyurethane foam comprising the same is provided to be used as a car interior material and protect human body from harmful materials causing new car syndromes. An antioxidative fermenting microorganism agent comprises a microorganism mixture, which comprises photosynthetic bacteria, yeast fungus, actinomyces and lactic acid bacteria in a ratio of 50-150:0.5-1.5:0.5-1.5:3-7, water, organic carbon source and natural salt in a weight ratio of 3-7:50-150:3-7:0.5-1.5 and is characterized in that it reduces volatile organic compounds generated from polyurethane foam. Polyurethane foam comprises 0.01-0.02 wt.% of the antioxidative fermenting microorganism agent regarding the total weight of a polyol. A car sheet is prepared from the polyurethane foam.
Abstract translation: 提供抗氧化发酵微生物剂以减少由聚氨酯泡沫产生的挥发性有机化合物并产生抗菌材料。 并且包括其的聚氨酯泡沫被提供用作汽车内部材料并且保护人体免受造成新的汽车综合征的有害物质的伤害。 抗氧化发酵微生物剂包含微生物混合物，其中包含比例为50-150:0.5-1.5:0.5-1.5:3-7的光合细菌，酵母菌，放线菌和乳酸菌，水，有机碳源和天然 盐的重量比为3-7：50-150：3-7：0.5-1.5，其特征在于它降低了由聚氨酯泡沫产生的挥发性有机化合物。 关于多元醇的总重量，聚氨酯泡沫包含0.01-0.02重量％的抗氧化发酵微生物剂。 由聚氨酯泡沫制备汽车板。
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5.发明授权피혁에서 발생하는 냄새 및 휘발성유기화합물을 저감시키는항산화발효미생물 제재, 이를 포함하는 피혁 및 이의제조방법 失效抗氧化剂发酵微生物代理减少皮革上的不可避免的小麦和挥发性有机化合物含有它们的皮革及其制造方法
公开(公告)号：KR100789594B1
公开(公告)日：2007-12-27
申请号：KR1020060042036
申请日：2006-05-10
Applicant: 현대다이모스(주) , 재단법인서울대학교산학협력재단
Abstract: 본발명은항산화발효미생물제재, 이를포함하는피혁및 이의제조방법에관한것으로서, 항산화발효미생물제재는피혁에서발생하는냄새및 휘발성유기화합물을저감시키는효과를가지고있어피혁에서발생하는유해물질로부터인체를보호하는작용을할 수있다. 또한, 본발명에따라제조된피혁은자동차내장재등으로사용된다.
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6.发明公开피혁에서 발생하는 냄새 및 휘발성유기화합물을 저감시키는항산화발효미생물 제재, 이를 포함하는 피혁 및 이의제조방법 失效抗氧化剂发酵微生物代理减少皮革上的不可避免的小麦和挥发性有机化合物含有它们的皮革及其制造方法
公开(公告)号：KR1020070109278A
公开(公告)日：2007-11-15
申请号：KR1020060042036
申请日：2006-05-10
Applicant: 현대다이모스(주) , 재단법인서울대학교산학협력재단
Abstract: 본발명은항산화발효미생물제재, 이를포함하는피혁및 이의제조방법에관한것으로서, 항산화발효미생물제재는피혁에서발생하는냄새및 휘발성유기화합물을저감시키는효과를가지고있어피혁에서발생하는유해물질로부터인체를보호하는작용을할 수있다. 또한, 본발명에따라제조된피혁은자동차내장재등으로사용된다.
Abstract translation: 提供抗氧化发酵微生物剂，含有该皮肤的皮革和制造皮革的方法，通过在皮革的染色过程中使用抗氧化剂发酵微生物来对皮革进行除臭。 抗氧化发酵微生物剂包含3-7重量％的微生物混合物，50-150重量％的水，3-7重量％的有机碳源，0.5-1.5重量％的天然盐。 通过以50-150:0.5-1.5:0.5-1.5:3-7.7的比例混合光合细菌，酵母，放线菌，乳杆菌，制备微生物混合物。 皮革是通过制备工艺，鞣制工艺，染色工艺和精加工工艺制造的。 在染色过程中，将0.05-0.15重量％的抗氧化发酵微生物加入到100重量％的化学品中。
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公开(公告)号：KR1020030046544A
公开(公告)日：2003-06-18
申请号：KR1020010074251
申请日：2001-11-27
Applicant: 재단법인서울대학교산학협력재단
IPC: C07C43/275
Abstract: PURPOSE: A meso-dihydroguaiaretic acid derivative, an inhibitor of the liver fibrosis containing the derivative, a Machilus thunbergii Sieb et Zucc. extract for inhibiting the liver fibrosis and a medical composition containing the extract for inhibiting the liver fibrosis are provided, wherein the derivative shows an excellent activity inhibiting the liver fibrosis. CONSTITUTION: The meso-dihydroguaiaretic acid derivative is represented by the formula 1, wherein R1 and R2 are independently H or an alkyl group of C1-C4; and R3 and R4 are independently an alkyl group of C1-C4 (but meso-dihydroguaiaretic acid is excluded). The Machilus thunbergii Sieb et Zucc. extract is obtained by extracting Machilus thunbergii Sieb et Zucc. with an alcohol of C1-C4, and optionally suspending it with water; fractionating the extracted one with CH2Cl2; and separating the obtained CH2Cl2 fraction by column chromatography.
Abstract translation: 目的：内消旋二氢愈创木酸衍生物，含有该衍生物的肝纤维化抑制剂，Machilus thunbergii Sieb et Zucc。 提供了用于抑制肝纤维化的提取物和含有用于抑制肝纤维化的提取物的医药组合物，其中该衍生物显示出抑制肝纤维化的优异活性。 构成：内消旋二氢愈创木酸衍生物由式1表示，其中R1和R2独立地为H或C1-C4的烷基; 并且R 3和R 4独立地是C 1 -C 4的烷基（但不包括内消旋 - 二氢愈老酸）。 Machilus thunbergii Sieb et Zucc。 提取物通过提取马齿苋提取物Sieb et Zucc获得。 与C1-C4的醇，并任选地用水悬浮; 用CH 2 Cl 2分离提取的物质; 并通过柱色谱法分离得到的CH 2 Cl 2馏分。
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8.发明公开간세포 보호활성을 나타내는 비자나무의 수피로부터분리한 다이벤질부틸락톤 리그난 유도체 및 이를유효성분으로 함유하는 간세포 보호 및 간 질환 치료용조성물 失效来自TORREYA NUCIFERA BARK展示肝细胞保护活性的DIBENZYLBUTYLLACTONE LIGNAN衍生物和含有其作为活性成分的组合物用于保护LI
公开(公告)号：KR1020030028921A
公开(公告)日：2003-04-11
申请号：KR1020010061217
申请日：2001-10-04
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K31/365
Abstract: PURPOSE: A pharmaceutical composition containing a dibenzylbutyllactone lignan derivative separated from the bark of Torreya nucifera(L.) Sieb. et Zucc. as an active component is provided. The dibenzylbutyllactone lignan derivative protects a liver cell from toxicity induced by carbon tetrachloride and galactosamine and effectively inhibits the proliferation of HSC2 liver. It is, therefore, effectively used in protection of the liver cell and treatment of acute, chronic liver disease. CONSTITUTION: The pharmaceutical composition contains a dibenzylbutyllactone lignan derivative represented by the formula(1) and a pharmaceutically acceptable salt. In formula, R1, R2, R3, R4 and R5 are each independently hydroxyl or methoxy groups. The dibenzylbutyllactone lignan derivative is prepared by extracting the bark of Torreya nucifera in lower alcohol at 20 to 80deg.C for 1 to 3hr, fractioning the extract with dichloromethane and then performing column chromatography.
Abstract translation: 目的：含有从Torreya nucifera（L。）Sieb的树皮分离的二苄基丁内酯木脂素衍生物的药物组合物。 等Zucc。 作为活性成分。 二苄基丁内酯木脂素衍生物保护肝细胞免受四氯化碳和半乳糖胺诱导的毒性，有效抑制HSC2肝脏的增殖。 因此，它有效地用于保护肝细胞和治疗急性，慢性肝病。 构成：药物组合物含有式（1）表示的二苄基丁内酯木酚素衍生物及其药学上可接受的盐。 在式中，R 1，R 2，R 3，R 4和R 5各自独立地为羟基或甲氧基。 二苄基丁内酯木脂素衍生物是通过在20〜80℃下将低分子量的Torreya Nucifera树皮提取1〜3小时，用二氯甲烷萃取萃取液，然后进行柱色谱法制备的。
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