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    사우치논을 포함하는 염증성 질환의 치료 및 예방용 조성물
    1.
    发明公开
    사우치논을 포함하는 염증성 질환의 치료 및 예방용 조성물 失效
    包含SAUCHINONE用于治疗和预防炎症性疾病的组合物

    公开(公告)号：KR1020030086819A

    公开(公告)日：2003-11-12

    申请号：KR1020020025007

    申请日：2002-05-07

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 김상건 ,  김영중 ,  이애경 ,  성상현

    IPC: A61K31/357

    Abstract: PURPOSE: Provided is a composition comprising, as an active ingredient, sauchinone for treatment and prophylaxis of inflammatory diseases. It has anti-inflammatory effect by inhibiting inducible expression of cyclooxygenase-2(COX-2). CONSTITUTION: A composition for treatment and prophylaxis of inflammatory diseases is characterized by comprising, as an active ingredient, sauchinone represented by the formula(I). The inflammatory diseases include articular rheumatism or asthma. The sauchinone is isolated and purified from the Saururs chinesis(Lour.) extract.

    Abstract translation: 目的：提供一种组合物，其包含用于治疗和预防炎症性疾病的作为活性成分的雄黄酮。 通过抑制环氧合酶-2（COX-2）的诱导表达具有抗炎作用。 构成：用于治疗和预防炎性疾病的组合物的特征在于，含有由式（I）表示的橙酮作为活性成分。 炎性疾病包括关节风湿病或哮喘。 sauchinone是从Saururs chinesis（Lour。）提取物中分离和纯化的。

    백선피 추출물 또는 리모노이드 화합물을 포함하는 퇴행성뇌신경계 질환의 예방 또는 치료용 조성물
    2.
    发明公开
    백선피 추출물 또는 리모노이드 화합물을 포함하는 퇴행성뇌신경계 질환의 예방 또는 치료용 조성물 有权
    用于预防或治疗包含DICTAMNUS DASYCARPUS TURCZ的神经病变疾病的组合物。 提取物或强力化合物

    公开(公告)号：KR1020090092601A

    公开(公告)日：2009-09-01

    申请号：KR1020080017933

    申请日：2008-02-27

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 김영중 ,  성상현 ,  윤정선

    IPC: A61K31/35 ,  A61K31/352 ,  A61K36/75 ,  A61P25/28

    Abstract: A composition for preventing or treating neurodegenerative diseases, which contains Dictamnus dasycarpus Turcz. extract or limonoid compound is provided to prevent and treat dementia, amnesia and Alzheimer disease. A composition for preventing or treating neurodegenerative diseases comprises C1-C4 alcohol extract of Dictamnus dasycarpus Turcz. The composition contains CHCl3 fraction, EtOAc fraction or n-BuOH fraction of alcohol extract. The composition is used for preventing or treating damage of memory, dementia, amnesia, or Alzheimer disease. The composition is used in the form of liquid, syrup, and capsule.

    Abstract translation: 用于预防或治疗神经变性疾病的组合物，其含有Dictamnus dasycarpus Turcz。 提取物或柠檬醛类化合物用于预防和治疗痴呆，遗忘症和阿尔茨海默病。 用于预防或治疗神经变性疾病的组合物包括Dictamnus dasycarpus Turcz的C1-C4醇提取物。 该组合物含有CHCl 3馏分，乙醇提取物的EtOAc级分或n-BuOH级分。 该组合物用于预防或治疗记忆，痴呆，遗忘症或阿尔茨海默病的损伤。 组合物以液体，糖浆和胶囊的形式使用。

    간섬유화 억제 활성을 갖는 메소-디히드로구아이레트산유도체
    3.
    发明公开
    간섬유화 억제 활성을 갖는 메소-디히드로구아이레트산유도체 失效
    具有活性抑制肝纤维化的肉豆蔻酸衍生物

    公开(公告)号：KR1020030046544A

    公开(公告)日：2003-06-18

    申请号：KR1020010074251

    申请日：2001-11-27

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 김영중 ,  이은주 ,  성상현 ,  마충제 ,  박혜영 ,  김진웅 ,  김상건

    IPC: C07C43/275

    Abstract: PURPOSE: A meso-dihydroguaiaretic acid derivative, an inhibitor of the liver fibrosis containing the derivative, a Machilus thunbergii Sieb et Zucc. extract for inhibiting the liver fibrosis and a medical composition containing the extract for inhibiting the liver fibrosis are provided, wherein the derivative shows an excellent activity inhibiting the liver fibrosis. CONSTITUTION: The meso-dihydroguaiaretic acid derivative is represented by the formula 1, wherein R1 and R2 are independently H or an alkyl group of C1-C4; and R3 and R4 are independently an alkyl group of C1-C4 (but meso-dihydroguaiaretic acid is excluded). The Machilus thunbergii Sieb et Zucc. extract is obtained by extracting Machilus thunbergii Sieb et Zucc. with an alcohol of C1-C4, and optionally suspending it with water; fractionating the extracted one with CH2Cl2; and separating the obtained CH2Cl2 fraction by column chromatography.

    Abstract translation: 目的：内消旋二氢愈创木酸衍生物，含有该衍生物的肝纤维化抑制剂，Machilus thunbergii Sieb et Zucc。 提供了用于抑制肝纤维化的提取物和含有用于抑制肝纤维化的提取物的医药组合物，其中该衍生物显示出抑制肝纤维化的优异活性。 构成：内消旋二氢愈创木酸衍生物由式1表示，其中R1和R2独立地为H或C1-C4的烷基; 并且R 3和R 4独立地是C 1 -C 4的烷基（但不包括内消旋 - 二氢愈老酸）。 Machilus thunbergii Sieb et Zucc。 提取物通过提取马齿苋提取物Sieb et Zucc获得。 与C1-C4的醇，并任选地用水悬浮; 用CH 2 Cl 2分离提取的物质; 并通过柱色谱法分离得到的CH 2 Cl 2馏分。

    간세포 보호활성을 나타내는 비자나무의 수피로부터분리한 다이벤질부틸락톤 리그난 유도체 및 이를유효성분으로 함유하는 간세포 보호 및 간 질환 치료용조성물
    4.
    发明公开
    간세포 보호활성을 나타내는 비자나무의 수피로부터분리한 다이벤질부틸락톤 리그난 유도체 및 이를유효성분으로 함유하는 간세포 보호 및 간 질환 치료용조성물 失效
    来自TORREYA NUCIFERA BARK展示肝细胞保护活性的DIBENZYLBUTYLLACTONE LIGNAN衍生物和含有其作为活性成分的组合物用于保护LI

    公开(公告)号：KR1020030028921A

    公开(公告)日：2003-04-11

    申请号：KR1020010061217

    申请日：2001-10-04

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 김영중 ,  장영표 ,  이은주 ,  김진웅 ,  김상건

    IPC: A61K31/365

    Abstract: PURPOSE: A pharmaceutical composition containing a dibenzylbutyllactone lignan derivative separated from the bark of Torreya nucifera(L.) Sieb. et Zucc. as an active component is provided. The dibenzylbutyllactone lignan derivative protects a liver cell from toxicity induced by carbon tetrachloride and galactosamine and effectively inhibits the proliferation of HSC2 liver. It is, therefore, effectively used in protection of the liver cell and treatment of acute, chronic liver disease. CONSTITUTION: The pharmaceutical composition contains a dibenzylbutyllactone lignan derivative represented by the formula(1) and a pharmaceutically acceptable salt. In formula, R1, R2, R3, R4 and R5 are each independently hydroxyl or methoxy groups. The dibenzylbutyllactone lignan derivative is prepared by extracting the bark of Torreya nucifera in lower alcohol at 20 to 80deg.C for 1 to 3hr, fractioning the extract with dichloromethane and then performing column chromatography.

    Abstract translation: 目的：含有从Torreya nucifera（L。）Sieb的树皮分离的二苄基丁内酯木脂素衍生物的药物组合物。 等Zucc。 作为活性成分。 二苄基丁内酯木脂素衍生物保护肝细胞免受四氯化碳和半乳糖胺诱导的毒性，有效抑制HSC2肝脏的增殖。 因此，它有效地用于保护肝细胞和治疗急性，慢性肝病。 构成：药物组合物含有式（1）表示的二苄基丁内酯木酚素衍生物及其药学上可接受的盐。 在式中，R 1，R 2，R 3，R 4和R 5各自独立地为羟基或甲氧基。 二苄基丁内酯木脂素衍生物是通过在20〜80℃下将低分子量的Torreya Nucifera树皮提取1〜3小时，用二氯甲烷萃取萃取液，然后进行柱色谱法制备的。

    간섬유화 억제 활성을 갖는 메소-디히드로구아이레트산유도체
    7.
    发明授权
    간섬유화 억제 활성을 갖는 메소-디히드로구아이레트산유도체 失效
    간섬유화억제활성을갖는메이 - - 디히드로구아이이트산유도체

    公开(公告)号：KR100470150B1

    公开(公告)日：2005-02-05

    申请号：KR1020010074251

    申请日：2001-11-27

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 김영중 ,  이은주 ,  성상현 ,  마충제 ,  박혜영 ,  김진웅 ,  김상건

    IPC: C07C43/275

    Abstract: PURPOSE: A meso-dihydroguaiaretic acid derivative, an inhibitor of the liver fibrosis containing the derivative, a Machilus thunbergii Sieb et Zucc. extract for inhibiting the liver fibrosis and a medical composition containing the extract for inhibiting the liver fibrosis are provided, wherein the derivative shows an excellent activity inhibiting the liver fibrosis. CONSTITUTION: The meso-dihydroguaiaretic acid derivative is represented by the formula 1, wherein R1 and R2 are independently H or an alkyl group of C1-C4; and R3 and R4 are independently an alkyl group of C1-C4 (but meso-dihydroguaiaretic acid is excluded). The Machilus thunbergii Sieb et Zucc. extract is obtained by extracting Machilus thunbergii Sieb et Zucc. with an alcohol of C1-C4, and optionally suspending it with water; fractionating the extracted one with CH2Cl2; and separating the obtained CH2Cl2 fraction by column chromatography.

    Abstract translation: 目的：内消旋二氢愈创木酸衍生物，含有该衍生物的肝纤维化抑制剂，Machilus thunbergii Sieb et Zucc。 提供了用于抑制肝纤维化的提取物和含有用于抑制肝纤维化的提取物的药物组合物，其中所述衍生物显示出抑制肝纤维化的优异活性。 构成：内消旋二氢愈创木酸衍生物由式1表示，其中R1和R2独立地为H或C1-C4的烷基; 并且R3和R4独立地为C1-C4的烷基（但不包括内消旋二氢愈创木酸）。 Machilus thunbergii Sieb et Zucc。 提取物通过提取Machilus thunbergii Sieb et Zucc获得。 与C1-C4的醇反应，并任选将其悬浮于水中; 用CH 2 Cl 2分馏萃取液; 并通过柱色谱分离所得的CH 2 Cl 2馏分。

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