公开(公告)号：KR100459088B1

公开(公告)日：2004-12-03

申请号：KR1020010061217

申请日：2001-10-04

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김영중 ,  장영표 ,  이은주 ,  김진웅 ,  김상건

IPC: A61K31/365

Abstract: PURPOSE: A pharmaceutical composition containing a dibenzylbutyllactone lignan derivative separated from the bark of Torreya nucifera(L.) Sieb. et Zucc. as an active component is provided. The dibenzylbutyllactone lignan derivative protects a liver cell from toxicity induced by carbon tetrachloride and galactosamine and effectively inhibits the proliferation of HSC2 liver. It is, therefore, effectively used in protection of the liver cell and treatment of acute, chronic liver disease. CONSTITUTION: The pharmaceutical composition contains a dibenzylbutyllactone lignan derivative represented by the formula(1) and a pharmaceutically acceptable salt. In formula, R1, R2, R3, R4 and R5 are each independently hydroxyl or methoxy groups. The dibenzylbutyllactone lignan derivative is prepared by extracting the bark of Torreya nucifera in lower alcohol at 20 to 80deg.C for 1 to 3hr, fractioning the extract with dichloromethane and then performing column chromatography.

Abstract translation: 用途：含有从Torreya nucifera（L。）Sieb的树皮中分离出的二苄基丁内酯木脂素衍生物的药物组合物。 et Zucc。 作为活性组分提供。 二苄基丁内酯木脂素衍生物保护肝细胞免受四氯化碳和半乳糖胺诱导的毒性，并有效抑制HSC2肝脏的增殖。 因此，它有效地用于保护肝细胞和治疗急性，慢性肝病。 组成：药物组合物含有由式（1）表示的二苄基丁内酯木脂素衍生物和药学上可接受的盐。 式中，R 1，R 2，R 3，R 4和R 5各自独立地为羟基或甲氧基。 二苄基丁内酯木脂素衍生物的制备方法是在20-80℃的低级醇中提取Torreya nucifera的树皮1至3小时，用二氯甲烷分级提取物，然后进行柱层析。

公开(公告)号：KR1020030028921A

公开(公告)日：2003-04-11

申请号：KR1020010061217

申请日：2001-10-04

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김영중 ,  장영표 ,  이은주 ,  김진웅 ,  김상건

IPC: A61K31/365

Abstract: PURPOSE: A pharmaceutical composition containing a dibenzylbutyllactone lignan derivative separated from the bark of Torreya nucifera(L.) Sieb. et Zucc. as an active component is provided. The dibenzylbutyllactone lignan derivative protects a liver cell from toxicity induced by carbon tetrachloride and galactosamine and effectively inhibits the proliferation of HSC2 liver. It is, therefore, effectively used in protection of the liver cell and treatment of acute, chronic liver disease. CONSTITUTION: The pharmaceutical composition contains a dibenzylbutyllactone lignan derivative represented by the formula(1) and a pharmaceutically acceptable salt. In formula, R1, R2, R3, R4 and R5 are each independently hydroxyl or methoxy groups. The dibenzylbutyllactone lignan derivative is prepared by extracting the bark of Torreya nucifera in lower alcohol at 20 to 80deg.C for 1 to 3hr, fractioning the extract with dichloromethane and then performing column chromatography.

Abstract translation: 目的：含有从Torreya nucifera（L。）Sieb的树皮分离的二苄基丁内酯木脂素衍生物的药物组合物。 等Zucc。 作为活性成分。 二苄基丁内酯木脂素衍生物保护肝细胞免受四氯化碳和半乳糖胺诱导的毒性，有效抑制HSC2肝脏的增殖。 因此，它有效地用于保护肝细胞和治疗急性，慢性肝病。 构成：药物组合物含有式（1）表示的二苄基丁内酯木酚素衍生物及其药学上可接受的盐。 在式中，R 1，R 2，R 3，R 4和R 5各自独立地为羟基或甲氧基。 二苄基丁内酯木脂素衍生物是通过在20〜80℃下将低分子量的Torreya Nucifera树皮提取1〜3小时，用二氯甲烷萃取萃取液，然后进行柱色谱法制备的。