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    신규한 2-아미노퀴나졸린 유도체 및 이를 유효성분으로 포함하는 항암제
    1.
    发明公开
    신규한 2-아미노퀴나졸린 유도체 및 이를 유효성분으로 포함하는 항암제 有权
    新型2-氨基喹唑啉衍生物和用于治疗包含其的肿瘤的药物组合物作为活性成分

    公开(公告)号：KR1020130084474A

    公开(公告)日：2013-07-25

    申请号：KR1020120005284

    申请日：2012-01-17

    Applicant: 한국과학기술연구원

    Inventor： 김은경 ,  김순남 ,  최종류 ,  장호진 ,  이도영 ,  김현태 ,  조중명 ,  노성구

    IPC: C07D401/14 ,  C07D401/12 ,  A61K31/444 ,  A61P35/00

    Abstract: PURPOSE: A novel aminoquinazoline derivative is provided to effectively suppress the activity of extracellular signal-regulated kinase 1/2 (ERK 1/2) and to effectively prevent and/or treat cancer in which cell proliferation is not regulated. CONSTITUTION: A compound of chemical formula 1, or a pharmaceutically acceptable salt, a hydrate, a solvate, or an isomer thereof is provided. A pharmaceutical composition for preventing and/or treating cancer contains the compound, the pharmaceutically acceptable salt, the hydrate, the solvate, or the isomer as an active ingredient. The cancer is caused by signal regulated kinase activity. A method for treating cancer comprises the step of administering the pharmaceutical composition to a patient.

    Abstract translation: 目的：提供一种新的氨基喹唑啉衍生物，有效抑制细胞外信号调节激酶1/2（ERK 1/2）的活性，并有效预防和/或治疗不调节细胞增殖的癌症。 构成：提供化学式1化合物或其药学上可接受的盐，水合物，溶剂合物或异构体。 用于预防和/或治疗癌症的药物组合物含有化合物，药学上可接受的盐，水合物，溶剂合物或异构体作为活性成分。 癌症是由信号调节激酶活性引起的。 治疗癌症的方法包括向患者施用药物组合物的步骤。

    아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
    2.
    发明公开
    아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제 有权
    氨基吡啶衍生物和包含其的细胞外信号调节激酶抑制剂

    公开(公告)号：KR1020120092768A

    公开(公告)日：2012-08-22

    申请号：KR1020110008458

    申请日：2011-01-27

    Applicant: 한국과학기술연구원

    Inventor： 김은경 ,  나정은 ,  김순남 ,  이도영 ,  이휘성 ,  장호진 ,  조중명 ,  노성구

    IPC: C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61P35/00

    Abstract: PURPOSE: A novel aminopyridine derivative is provided to effectively suppress extracellular signal-regulated kinase 1 and/or 2 activity and to treat cancer. CONSTITUTION: A novel aminopyrdine derivative having an extracellular signal-regulated kinase activity is denoted by chemical formula 1. A composition for suppressing extracellular signal-regulated kinase activity contains the compound of chemical formula 1 or pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof as an active ingredient. A composition for preventing or treating cancer contains the compound, salt, hydrate, solvate, or isomer as an active ingredient.

    Abstract translation: 目的：提供新的氨基吡啶衍生物，以有效抑制细胞外信号调节激酶1和/或2活性并治疗癌症。 组成：具有细胞外信号调节激酶活性的新型氨基吡啶衍生物由化学式1表示。用于抑制细胞外信号调节激酶活性的组合物含有化学式1的化合物或其药学上可接受的盐，水合物，溶剂化物或异构体 作为活性成分。 用于预防或治疗癌症的组合物含有化合物，盐，水合物，溶剂合物或异构体作为活性成分。

    포스포디에스테라제 저해 활성을 가지는 화합물 및 이의 용도
    3.
    发明公开
    포스포디에스테라제 저해 활성을 가지는 화합물 및 이의 용도 有权
    具有抗磷酸酯酶的抑制活性的化合物及其用途

    公开(公告)号：KR1020110029653A

    公开(公告)日：2011-03-23

    申请号：KR1020090087426

    申请日：2009-09-16

    Applicant: 한국과학기술연구원

    Inventor： 김은경 ,  조중명 ,  노성구 ,  장호진 ,  최종류 ,  이휘성 ,  정원근 ,  이승철 ,  최은아

    IPC: C07D231/04 ,  C07D231/02 ,  A61K31/433 ,  A61P25/28

    Abstract: PURPOSE: A compound with an activity of suppressing phosphodiesterasse is provided to be used as a pharmaceutical composition for preventing or treating central nervous system diseases. CONSTITUTION: A compound with an activity of suppressing phosphodiesterase is denoted by chemical formula 1. A pharmaceutical composition for preventing or treating central nervous system diseases contains a compound of chemical formula 2, pharmaceutically acceptable salt, hydrate, or solvent thereof as an active ingredient. The central nervous system diseases are mild cognitive impairment, Lewy body dementia, vascular dementais, stroke, AIDS dementia complex, schizophrenia, manic-depressive insanity, or Huntington's disease.

    Abstract translation: 目的：提供具有抑制磷酸二酯的活性的化合物作为预防或治疗中枢神经系统疾病的药物组合物。 构成：具有抑制磷酸二酯酶活性的化合物由化学式1表示。用于预防或治疗中枢神经系统疾病的药物组合物含有化学式2的化合物，其药学上可接受的盐，水合物或其溶剂作为活性成分。 中枢神经系统疾病是轻度认知障碍，路易体痴呆，血管性痴呆，中风，艾滋病痴呆综合征，精神分裂症，躁狂抑郁性精神病或亨廷顿舞蹈病。

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