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公开(公告)号：KR100377328B1
公开(公告)日：2003-03-26
申请号：KR1020007007188
申请日：1998-12-23
Applicant: 한국과학기술연구원
IPC: C07F13/00
CPC classification number: C07C53/122 , C07C53/124 , C07C211/10 , C07C211/11 , C07C211/18 , C07C211/36 , C07D309/04 , C07F15/0093
Abstract: Platinum (IV) complexes for oral administration represented by the structural formula where A-A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(+/-)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.
Abstract translation: 用于口服给药的铂（IV）复合物由以下结构式表示：其中AA是可以螯合铂的对称二胺并且选自乙二胺，t（+/-） - 1,2-二氨基环己烷， 2-二甲基-1,3-丙二胺，环己烷-1,1-二甲胺和四氢-4H-吡喃-4,4-二甲胺; R是丙酰基，丁酰基或戊酰基。 这些复合物可用于治疗癌症。
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公开(公告)号：KR1020000064233A
公开(公告)日：2000-11-06
申请号：KR1020007007188
申请日：1998-12-23
Applicant: 한국과학기술연구원
IPC: C07F13/00
CPC classification number: C07C53/122 , C07C53/124 , C07C211/10 , C07C211/11 , C07C211/18 , C07C211/36 , C07D309/04 , C07F15/0093
Abstract: PURPOSE: Anticancer (iv) complexes excellent in lipoid solubility when orally administered and absorbable in the stomach and the intestinal and process for preparation thereof by oxidizing diamine platinum complexes with hydrogen oxide and carrying out an electrophilic substitution reaction of four hydroxyl groups of the obtained diaminetetrahydroxyplatinum are provided which exhibit excellent anticancer effect. CONSTITUTION: Platinum complexes for oral administration represented by the structural formula (I) are prepared. In formula A-A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(+/-)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.
Abstract translation: 目的：抗口服（iv）口服给药并在胃和肠中可吸收的脂质溶解性优异，通过用二氧化氢氧化二胺铂络合物并进行所得二氨基四羟基铂的四个羟基的亲电取代反应来制备 具有优异的抗癌作用。 构成：制备由结构式（I）表示的用于口服的铂络合物。 式中AA是可与铂螯合的对称二胺，选自乙二胺，t（+/-） - 1,2-二氨基环己烷，2,2-二甲基-1,3-丙二胺，环己烷 - 1,1-二甲胺和四氢-4H-吡喃-4,4-二甲胺; R是丙酰基，丁酰基或戊酰基。 这些复合物可用于治疗癌症。
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公开(公告)号：KR100246722B1
公开(公告)日：2000-04-01
申请号：KR1019970079743
申请日：1997-12-30
Applicant: 한국과학기술연구원
IPC: C07F13/00
CPC classification number: C07C53/122 , C07C53/124 , C07C211/10 , C07C211/11 , C07C211/18 , C07C211/36 , C07D309/04 , C07F15/0093
Abstract: 다음 일반식(I)로 표시되는 경구 투여용 백금(Ⅳ) 착화합물 항암제 및 그의 제조방법이 제공된다.
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