Abstract:
본 발명은 동맥색전술에 이용가능한 에멀젼으로 조성가능한 파클리탁셀 혼합 조성물, 그의 유중수형 (water-in-oil (w/o)) 에멀젼 조성물 및 그 제조방법에 관한 것이다. 본 발명의 에멀젼 제형은 수용성 및 지용성 약제를 추가로 포함할 수 있으므로 항암제 복합제등 복합제형을 용이하게 제조할 수 있다.
Abstract:
PURPOSE: A process of preparing a paclitaxel oily composition for chemoembolization by adding paclitaxel to an oily contrast medium and then agitating is provided. The composition is easy to manufacture and sterilize and more physiochemically stable than conventional adriamycin/lipiodol preparation. CONSTITUTION: The paclitaxel oily composition is prepared by mixing 0.0001 to 10mg paclitaxel with 1ml oily contrast medium under sterilization conditions, agitating at room temperature and then sterilized by gamma ray. The oily contrast medium is iodized oil having an iodine content of 30 to 50% selected from iodized poppy seed oil, ethiodol and iodized soybean oil. The composition optionally contains 0.1 to 1ml animal oil such as squalane, vegetable oil such as soybean oil or a mixture thereof, based on 1ml oily contrast medium.
Abstract:
휴대용건강지표측정장치는대상체의망막안쪽에있는혈관으로적외선을조사하는광원; 상기망막안쪽에있는혈관에서반사된빛을받아들이는광 다이오드; 및상기광 다이오드로입사된빛의세기를측정하여상기망막안쪽에있는혈관의건강지표와관련된값을연산하는프로세서를포함할수 있다. 이에따라, 눈이빛에대하여망막까지투명하다는점을이용하여편리하고안전하게망막안쪽의혈관에있는건강지표를정밀하게측정할수 있다.
Abstract:
PURPOSE: A method for observing a target object and an optical device thereof are provided to observe a target object using a phase difference of lights which have vibration directions of different magnetic fields. CONSTITUTION: A light generating unit(110) applies first and second light signals, which are vertically polarized, to a target object through one light path. A reflective light processing unit(130) forms an image per wavelength of a target object. A reflective mirror(120) transmits first and second reflective signals to the reflective light processing unit. An image observing unit(160) provides an image by wavelength to a user.
Abstract:
휴대용 건강 지표 측정 장치는 대상체의 망막 안쪽에 있는 혈관으로 적외선을 조사하는 광원; 상기 망막 안쪽에 있는 혈관에서 반사된 빛을 받아들이는 광 다이오드; 및 상기 광 다이오드로 입사된 빛의 세기를 측정하여 상기 망막 안쪽에 있는 혈관의 건강 지표와 관련된 값을 연산하는 프로세서를 포함할 수 있다. 이에 따라, 눈이 빛에 대하여 망막까지 투명하다는 점을 이용하여 편리하고 안전하게 망막 안쪽의 혈관에 있는 건강 지표를 정밀하게 측정할 수 있다.
Abstract:
PURPOSE: A paclitaxel mixed composition, its water-in-oil type emulsion formulation for chemoembolization and a preparation method thereof are provided, thereby improving stability of the emulsion formulation, and applying the paclitaxel to artery chemoembolization. CONSTITUTION: The paclitaxel mixed composition comprises 50 to 98.9%(v/v) of oily contrast media containing 0.01 to 1%(w/v) of paclitaxel, and 0.1 to 50%(v/v) of water-soluble contrast media. The water-in-oil type emulsion formulation for chemoembolization comprises 50 to 98.9%(v/v) of oily contrast media, 0.1 to 50%(v/v) of water-soluble contrast media, and 0.01 to 1%(w/v) of paclitaxel, wherein the oily contrast media are iodized oil containing 30 to 50% of iodine content selected from iodized poppy seed oil, ethiodol and iodized soybean oil; the water-soluble contrast media are selected from Metrizamide, Diatrizoate, Ioxaglate, Iopentol, Iopamidol, Iomeprol, Iotrolan, Iohexol, Ioversol, Ioxilan, Iopromide, Iodixanol or Iobitridol.