公开(公告)号：KR101056523B1

公开(公告)日：2011-08-11

申请号：KR1020080111212

申请日：2008-11-10

Applicant: 한국과학기술원

Inventor： 이희승 ,  옥태동 ,  이주희 ,  임지수 ,  박현규 ,  정철희 ,  박철민

IPC: C07D239/08

CPC classification number: Y02P20/55

Abstract: 본 발명은 PNA(Peptide Nucleic Acid)에 관한 것으로서, 보다 상세하게는 RNA에 선택적으로 결합하고 키랄성을 갖는 신규한 PNA 모노머(PNA monomer)인 γ
3 -PNA 모노머 분자, 상기 γ
3 -PNA 모노머의 제조 방법, 및 상기 γ
3 -PNA를 포함하는 혼성 PNA 올리고머에 관한 것이다.
또한 본 발명은 상기 혼성 PNA 올리고머를 유기체에서 분리된 RNA와 선택적으로 결합시키는 것을 특징으로 하는 유전자 발현의 조절 방법, 상기 혼성 PNA 올리고머를 유기체 세포 내의 RNA를 포함하는 시료와 접촉시키는 것을 특징으로 하는 RNA 분해 유도 방법, 및 상기 혼성 PNA 올리고머와 세포 또는 바이러스의 RNA를 포함하는 용액을 접촉시키는 것을 특징으로 하는 세포 또는 바이러스의 사멸 방법에 관한 것이다.
PNA, gamma3-PNA, aegPNA

Abstract translation: 本发明涉及PNA（肽核酸），更具体地涉及选择性结合RNA并具有手性的新型PNA单体（PNA单体）。

公开(公告)号：KR100770433B1

公开(公告)日：2007-10-26

申请号：KR1020060044851

申请日：2006-05-18

Applicant: 세종대학교산학협력단 ,  한국과학기술원

Inventor： 정형조 ,  박철민 ,  조상원 ,  이인원

IPC: E01D19/16 ,  E01D11/00 ,  F16F15/023

CPC classification number: E01D19/16 ,  E01D11/00 ,  F16F15/023

Abstract: A damping device for suppressing vibration of a cable is provided to control vibration of cables of a cable-stayed bridge without complex controller or measuring device by installing a damper between linking members. A damping device for suppressing vibration of a cable comprises a fixed member(210), third and fourth links(231,232), clamps(240,241), first and second links(221,222), and a damper(250). The fixed member is fixed to a structure. The third and fourth links pivots at a first joint(211) integrated with the fixed member. The clamps hold a cable(100). One ends of the first and second links pivot at second and third joints(223,234) connected with the third and fourth links and the other ends of the first and second links are integrated with the clamps rotatably. The damper is interposed between the first and the third joint horizontally.

Abstract translation: 提供一种用于抑制电缆振动的阻尼装置，通过在连接构件之间安装阻尼器来控制无复式控制器或测量装置的斜拉桥电缆的振动。 一种用于抑制电缆振动的阻尼装置，包括固定部件（210），第三和第四连杆（231,232），夹具（240,241），第一和第二连杆（221,222）以及阻尼器（250）。 固定构件固定在结构上。 第三和第四连杆在与固定构件一体化的第一接头（211）上枢转。 夹具夹住电缆（100）。 第一和第二连杆的一端在与第三和第四连杆连接的第二和第三关节（223,234）处枢转，并且第一和第二连杆的另一端可旋转地与夹具成一体。 阻尼器水平插入第一和第三关节之间。

公开(公告)号：KR1020010037958A

公开(公告)日：2001-05-15

申请号：KR1019990045742

申请日：1999-10-21

Applicant: 한국과학기술원

Inventor： 이정권 ,  박철민

IPC: G01K11/00 ,  G01K11/24

CPC classification number: G01K11/22

Abstract: PURPOSE: A method for optimally deciding position of a sensor when measuring the temperature by using sound wave is provided to measure the more accurate temperature distribution with using the same number of sensors. CONSTITUTION: A method for optimally deciding position of a sensor when measuring the temperature by using sound wave includes the steps of arbitrarily arranging N number of sensors on a border line of a surface to be measured(S1), calculating transfer matrix to the position of the sensors(S2), performing singular value decomposition to the transfer matrix for obtaining Efl(Effective independence) values to each path(S3), adding the Efls related to each path for obtaining each Efl value of the sensors(S4), removing the sensor having the smallest Efl value(S5), and repeating the former steps until the remained number of the sensors are equal to the target number.

Abstract translation: 目的：提供一种通过使用声波来测量传感器位置的最佳方法，以便通过使用相同数量的传感器来测量更准确的温度分布。 构成：通过使用声波测定温度时的传感器位置的最佳判定方法包括：将N个传感器任意设置在被测定面的边界线上的步骤（S1），将传送矩阵计算到 传感器（S2）对传送矩阵执行奇异值分解以获得每个路径（S3）的Efl（有效独立性）值，添加与用于获得传感器的每个Efl值的各路径相关的Efls（S4），去除 传感器具有最小的Efl值（S5），并且重复前述步骤，直到传感器的剩余数量等于目标数量。

公开(公告)号：KR1020100052266A

公开(公告)日：2010-05-19

申请号：KR1020080111212

申请日：2008-11-10

Applicant: 한국과학기술원

Inventor： 이희승 ,  옥태동 ,  이주희 ,  임지수 ,  박현규 ,  정철희 ,  박철민

IPC: C07D239/08

CPC classification number: Y02P20/55

Abstract: PURPOSE: A novel PNA(peptide nucleic acid) and hybridized PNA oligomer using the same is provided to selectively bind to RNA and to treat and diagnose various diseases targeting RNA. CONSTITUTION: A gamma3-PNA monomer molecule is denoted by chemical formula 18. A method for preparing gamma3-PNA comprises: a step of performing ring-opening reaction of (R)-azidomethyl gamma-butylolactone(chemical formula 1) to obtain a compound of chemical formula 2; a step of reacting nucleic acid with the compound of chemical formula 2 or performing protection reaction of exocyclic amino or hydroxyl group of nucleic acid after reacting nucleic acid with the compound of chemical formula 2; a step of reducing azide from the compound which is bound to nucleic acid; and a step of attaching a protection group to obtain a compound of chemical formula 19.

Abstract translation: 目的：提供新型PNA（肽核酸）和使用其的杂交的PNA寡聚体以选择性结合RNA并治疗和诊断靶向RNA的各种疾病。 构成：γ3-PNA单体分子由化学式18表示。制备γ3-PNA的方法包括：（R） - 叠氮基甲基γ-丁内酯（化学式1）进行开环反应的步骤，得到化合物 化学式2; 在核酸与化学式2的化合物反应后，使核酸与化学式2的化合物反应或进行核酸的环外氨基或羟基的保护反应的步骤; 从与核酸结合的化合物中还原叠氮化物的步骤; 以及附着保护基以获得化学式19的化合物的步骤。

公开(公告)号：KR100306121B1

公开(公告)日：2001-11-14

申请号：KR1019990045742

申请日：1999-10-21

Applicant: 한국과학기술원

Inventor： 이정권 ,  박철민

IPC: G01K11/00 ,  G01K11/24

CPC classification number: G01K11/22

Abstract: 본발명은 EfI방법(Effective independence method)을이용하여주어진오차한계를만족시키는최소의센서개수를구하고오차를최소화하는데적합한센서의위치를결정함으로써정확한온도분포를측정한다. 위와같은목적을달성하기위한본 발명은, N개의센서를임의로측정면의경계선상에배치하는제1단계와, 상기센서들의위치에대해전달행렬을계산하는제2단계와, 상기전달행렬에대해특이치분해를수행하여각각의경로에대한 EfI값(EfI)들을구하는제3단계와, 각각의경로에대한 EfI값(EfI)들을합하여상기센서들의 EfI값(EfI)을각각구하는제4단계와, EfI값(EfI)이가장작은센서를제거하는제5단계및, 남아있는센서의개수(N)가최종목표로하는센서의개수(N)와같아질때까지제2단계내지제5단계를반복하는제6단계를포함한다. 이때, 최종목표로하는센서의개수는센서의개수를줄여나가면서전달행렬의조건수의변화를계산하고, 그때 얻어진곡선에서조건수가급격하게커지는곳을찾음으로써알아낸최소의센서개수보다크게설정된다.