公开(公告)号：KR1020040017002A

公开(公告)日：2004-02-26

申请号：KR1020020049074

申请日：2002-08-20

Applicant: 한국화학연구원

Inventor： 이해방 ,  성하수 ,  강길선 ,  안태군 ,  강희정 ,  이진수 ,  정제교

IPC: A61K47/00

CPC classification number: A61K9/0004 ,  A61K9/0014 ,  A61K31/505 ,  A61K47/30

Abstract: PURPOSE: Provided is a locally implantable pharmaceutical preparation of anticancer agent containing an osmotic agent. Therefore, its drug release is controlled and its cytotoxicity is increased. CONSTITUTION: A locally implantable pharmaceutical preparation of anticancer agent is characterized in that a pharmaceutical composition consisting of nitrosourea based anticancer agents and biodegradable polymers is added with 1-50 wt.% of an osmotic agent selected from salt, saccharides and saccharide mixtures.

Abstract translation: 目的：提供含有渗透剂的抗癌剂的局部可植入药物制剂。 因此，其药物释放受到控制，其细胞毒性增加。 构成：抗癌剂的局部可植入药物制剂的特征在于，由以亚硝基脲为基础的抗癌剂和可生物降解聚合物组成的药物组合物中加入1-50重量％的选自盐，糖和糖混合物的渗透剂。

公开(公告)号：KR1020040040720A

公开(公告)日：2004-05-13

申请号：KR1020020068919

申请日：2002-11-07

Applicant: 한국화학연구원

Inventor： 이해방 ,  강길선 ,  성하수 ,  이진수 ,  안태군 ,  강복기

IPC: A61K47/44

CPC classification number: A61K9/1075 ,  A61K9/0004 ,  A61K9/0024 ,  A61K31/17 ,  A61K49/0438

Abstract: PURPOSE: Provided is a locally implantable anticancer agent using the self-microemulsion system which allows oil, an imaging reagent and a surfactant to form a protection layer in aqueous solution in order to inhibit the hydrolysis of the anticancer agent, and consequently to increase the stability thereof. CONSTITUTION: A locally implantable anticancer agent is characterized by using the self-microemulsion system composed of a pharmaceutical composition which consists of a nitrosourea based anticancer agent and a biodegradable polymer and is added with 1-10 wt.% of an imaging reagent, 1-10 wt.% of oil selected from C4-18 fatty acid derivatives, and 0-3 wt.% of a surfactant.

Abstract translation: 目的：提供一种使用自微乳液系统的局部植入式抗癌剂，其允许油，成像剂和表面活性剂在水溶液中形成保护层，以抑制抗癌剂的水解，从而提高稳定性 它们。 构成：本地可植入抗癌剂的特征在于使用由基于亚硝基脲的抗癌剂和可生物降解的聚合物组成的药物组合物组成的自微乳液体系，并添加1-10重量％的成像试剂， 10重量％的选自C4-18脂肪酸衍生物的油和0-3重量％的表面活性剂。

公开(公告)号：KR100482650B1

公开(公告)日：2005-04-14

申请号：KR1020020068919

申请日：2002-11-07

Applicant: 한국화학연구원

Inventor： 이해방 ,  강길선 ,  성하수 ,  이진수 ,  안태군 ,  강복기

IPC: A61K47/44

Abstract: 본 발명은 자가미세유화형 에멀젼 시스템을 이용한 국소이식형 항암제제에 관한 것으로서, 더욱 상세하게는 나이트로소우레아계 항암제 및 항암제를 서방화할 수 있는 생분해성 고분자로 이루어진 약제조성물에 특정의 오일, 조영제 및 계면활성제를 첨가하여 디스크 형태로 제형화된 것으로, 생체 조직 내 수상(물, 혈액)에 노출되어서는 자발적으로 오일 및 조영제가 항암제의 가수분해를 억제하는 보호층을 형성하게 되는 자가미세유화형 에멀젼 시스템에 의하여 항암제의 안정성을 증진시키는 효과를 얻고 있는 국소이식형 항암제제에 관한 것이다.

公开(公告)号：KR1020030027422A

公开(公告)日：2003-04-07

申请号：KR1020010060657

申请日：2001-09-28

Applicant: 한국화학연구원

Inventor： 이해방 ,  강길선 ,  조진철 ,  조선행 ,  안태군

IPC: A61K47/48

CPC classification number: A61K47/6949 ,  A61K31/546

Abstract: PURPOSE: Provided is a pharmaceutical composition obtained by including cefuroxime axetil with sodium alginate and then formulating into dry syrups to suppress a bitter taste of cefuroxime axetil. The composition is harmless to the human body and improves compliance by a patient. CONSTITUTION: The pharmaceutical composition is prepared by mixing 1 part by weight of cefuroxime axetil, 2 to 10 parts by weight of sodium alginate, 1 to 3 parts by weight of calcium chloride as a cross-linking agent, 1 to 2 parts by weight of stearic acid, 15 to 25 parts by weight of a pharmaceutically acceptable disintegrating agent and 5 to 15 parts by weight of pharmaceutically acceptable sugars.

Abstract translation: 目的：提供通过将头孢呋辛酯与藻酸钠包埋，然后配制成干糖浆以抑制头孢呋辛酯的苦味而得到的药物组合物。 组合物对人体无害，并改善患者的依从性。 构成：通过将1重量份头孢呋辛酯，2〜10重量份藻酸钠，1〜3重量份作为交联剂的氯化钙，1〜2重量份的 硬脂酸，15至25重量份的药学上可接受的崩解剂和5至15重量份的药学上可接受的糖。