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公开(公告)号：KR100952102B1
公开(公告)日：2010-04-13
申请号：KR1020070086890
申请日：2007-08-29
Applicant: 한양대학교 산학협력단
IPC: C12Q1/68
Abstract: 본 발명은 마이크로 중합효소 연쇄반응용 칩을 마이크로 반응조칩과 마이크로 히터칩으로 분리 제작하여 마이크로 반응조칩을 일회용으로, 마이크로 히터칩을 반영구적으로 사용하게 함으로써, 전체적으로 소요되는 제작 비용과 시간을 최소화시키게 하고, 인력을 절감시키게 하는 마이크로 중합효소 연쇄반응용 칩 및 이의 제조방법을 제공하는데 그 특징이 있다.
또한, 본 발명은 일체형 마이크로 중합효소 연쇄반응용 칩에 비해 제작을 용이하게 하는 동시에 저렴한 가격에 의해 대량생산을 가능하게 하는 마이크로 중합효소 연쇄반응용 칩 및 이의 제조방법을 제공하는데 있다.
또한, 본 발명은 전체적인 유전자 검사 및 생화학적 실험에 대한 사용상의 신뢰도 및 만족도를 극대화시키게 하는 마이크로 중합효소 연쇄반응용 칩 및 이의 제조방법을 제공하는데 있다.
중합효소 연쇄반응, PCR, PDMS, Chip, 유리-
公开(公告)号：KR100756874B1
公开(公告)日：2007-09-07
申请号：KR1020060027419
申请日：2006-03-27
Applicant: 한양대학교 산학협력단
IPC: C12Q1/68
CPC classification number: B01L9/527 , B01L3/5027 , C12M1/38 , C12Q1/686
Abstract: A micro bio chip for polymerase chain reaction and a manufacture method thereof are provided to eliminate the additional sample-introducing device and inhibit foam generation caused by the conventional channel type bio chip by conjugating PDMS(polydimethylsiloxane) to glass and reduce the using amount of sample and time, so that efficiency and accuracy of PCR are improved. A micro bio chip for polymerase chain reaction comprises a PDMS chip(10) into which a sample is easily introduced, and a glass chip which is treated by oxygen plasma, regulates the temperature and is conjugated to the PDMS chip, wherein one side of the glass chip has a micro heater consisting of chromium and gold thin film and a heat resistant sensor, a region for applying the electric source to the micro heater, a region for applying the electric current to the heat resistant sensor for measuring resistance, and a region for detecting the electric pressure value generated by relation between the resistance and electric current. The PDMS chip has a reaction tank(11) with the oblique line type micro channel structure.
Abstract translation: 提供了用于聚合酶链式反应的微生物芯片及其制造方法，以通过将PDMS（聚二甲基硅氧烷）与玻璃结合并减少样品的使用量来消除额外的样品引入装置并抑制由常规通道型生物芯片引起的泡沫生成 和时间，从而提高PCR的效率和准确性。 用于聚合酶链反应的微生物芯片包括容易引入样品的PDMS芯片（10）和用氧等离子体处理的玻璃芯片，调节温度并与PDMS芯片共轭，其中 玻璃芯片具有由铬和金薄膜构成的微加热器和耐热传感器，将电源施加到微加热器的区域，用于将电流施加到用于测量电阻的耐热传感器的区域，以及区域 用于检测由电阻和电流之间的关系产生的电压值。 PDMS芯片具有具有斜线型微通道结构的反应槽（11）。
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公开(公告)号：KR1020090021957A
公开(公告)日：2009-03-04
申请号：KR1020070086890
申请日：2007-08-29
Applicant: 한양대학교 산학협력단
IPC: C12Q1/68
CPC classification number: B01L3/5027 , B01L7/52 , C12Q1/686
Abstract: Provided is a method for manufacturing a chip for a polymerase chain reaction, which includes a disposable micro reaction bath chip and a semi-permanent micro heater chip, to reduce manufacturing costs and time. A method for manufacturing a chip(100) with a micro reaction bath chip(10) and a micro heater chip(20) for a polymerase chain reaction comprises the following steps. The micro reaction bath chip injects a sample for a biochemistry experiment. The micro heater chip heats the sample and controls a temperature of the sample. The micro reaction bath chip is located above the micro heater chip to be separated from the micro heater chip.
Abstract translation: 提供一种用于聚合酶链式反应的芯片的制造方法，其包括一次性微反应槽芯片和半永久性微加热器芯片，以降低制造成本和时间。 利用微反应槽芯片（10）和用于聚合酶链式反应的微加热器芯片（20）制造芯片（100）的方法包括以下步骤。 微反应槽芯片注入生物化学实验样品。 微加热器芯片加热样品并控制样品的温度。 微反应槽芯片位于微加热器芯片上方，与微加热器芯片分离。
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公开(公告)号：KR1020080067797A
公开(公告)日：2008-07-22
申请号：KR1020070005147
申请日：2007-01-17
Applicant: 한양대학교 산학협력단
CPC classification number: B81B3/0018 , B81B3/0035 , B81B7/008 , B81B2201/0214 , B81B2201/036 , B81B2201/054 , B81B2201/06
Abstract: A thermo-pneumatic micro pump chip applicable to a micro bio chip and a manufacturing method thereof are provided to increase precision of flow control of a pump by bonding a poly dimethyl siloxane(PDMS) chip with a glass chip integrally. A thermo-pneumatic micro pump chip(100) that is applicable to a micro bio chip comprises a glass chip(10) and a PDMS chip(20) that are integrally bonded to each other. The glass chip is equipped with a heater(11) and a sensor. In addition, the PDMS chip is formed on an upper surface of the glass chip and moves fluid sample in a desired direction.
Abstract translation: 提供了适用于微生物芯片的热气动微型泵芯片及其制造方法，以通过将聚二甲基硅氧烷（PDMS）芯片与玻璃芯片整体结合来提高泵的流量控制精度。 适用于微生物芯片的热气动微型泵芯片（100）包括彼此一体地结合的玻璃芯片（10）和PDMS芯片（20）。 玻璃芯片配有加热器（11）和传感器。 此外，PDMS芯片形成在玻璃芯片的上表面上，并使流体样品沿期望的方向移动。
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