公开(公告)号：DE60117157T2

公开(公告)日：2006-09-21

申请号：DE60117157

申请日：2001-09-20

Applicant: ABBOTT LAB

Inventor： MCCLELLAN WILLIAM ,  OOST THORSTEN ,  BRUNCKO MILAN ,  WANG XILU ,  AUGERI J ,  BAUMEISTER A ,  DICKMAN A ,  DING HONG ,  DINGES JURGEN ,  FESIK W ,  HAJDUK J ,  KUNZER R ,  NETTESHEIM G ,  PETROS M ,  ROSENBERG H ,  SHEN WANG ,  THOMAS A ,  WENDT D

IPC: C07C311/51 ,  A61K31/18 ,  A61K31/428 ,  A61K31/63 ,  A61K31/635 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07C311/46 ,  C07C317/28 ,  C07C323/12 ,  C07C323/17 ,  C07C323/25 ,  C07C323/30 ,  C07C323/37 ,  C07C323/43 ,  C07C323/44 ,  C07C323/48 ,  C07C323/58 ,  C07C323/60 ,  C07D203/10 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/24 ,  C07D207/40 ,  C07D207/404 ,  C07D209/08 ,  C07D209/52 ,  C07D209/54 ,  C07D209/96 ,  C07D211/14 ,  C07D211/44 ,  C07D211/70 ,  C07D211/74 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/71 ,  C07D215/14 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D215/48 ,  C07D217/04 ,  C07D221/20 ,  C07D231/12 ,  C07D233/60 ,  C07D235/08 ,  C07D235/26 ,  C07D241/08 ,  C07D241/16 ,  C07D249/04 ,  C07D263/32 ,  C07D263/56 ,  C07D263/58 ,  C07D277/62 ,  C07D277/64 ,  C07D295/13 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/14 ,  C07D317/54 ,  C07D333/28 ,  C07D333/68 ,  C07D333/70 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D417/12 ,  C07D451/02 ,  C07D491/107

公开(公告)号：DE60020547T2

公开(公告)日：2006-05-04

申请号：DE60020547

申请日：2000-04-07

Applicant: ABBOTT LAB

Inventor： FESIK W ,  AUGERI J

IPC: C07B59/00 ,  C12N15/09 ,  C07C51/09 ,  C07C51/353 ,  C07C59/185 ,  C07C229/08 ,  C07K1/107 ,  C07K1/13 ,  C07K14/47 ,  C12N9/64 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P21/00 ,  C12P21/02

Abstract: Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with C or C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-( C)butyric acid and 2-keto-3-( C-methyl)-4-( C)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.

公开(公告)号：DE69615674T2

公开(公告)日：2002-07-11

申请号：DE69615674

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： ARENDSEN L ,  BAKER R ,  FAKHOURY A ,  FUNG L ,  GARVEY S ,  MCCLELLAN J ,  O'CONNOR J ,  PRASAD N ,  ROCKWAY W ,  ROSENBERG H ,  STEIN H ,  SHEN WANG ,  STOUT M ,  SULLIVAN M ,  AUGERI J

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K31/19 ,  A61K31/16

Abstract: The present invention provides a compound of formula (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：DE60117157D1

公开(公告)日：2006-04-20

申请号：DE60117157

申请日：2001-09-20

Applicant: ABBOTT LAB

Inventor： MCCLELLAN WILLIAM ,  OOST THORSTEN ,  BRUNCKO MILAN ,  WANG XILU ,  AUGERI J ,  BAUMEISTER A ,  DICKMAN A ,  DING HONG ,  DINGES JURGEN ,  FESIK W ,  HAJDUK J ,  KUNZER R ,  NETTESHEIM G ,  PETROS M ,  ROSENBERG H ,  SHEN WANG ,  THOMAS A ,  WENDT D

IPC: C07C311/51 ,  A61K31/18 ,  A61K31/428 ,  A61K31/63 ,  A61K31/635 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07C311/46 ,  C07C317/28 ,  C07C323/12 ,  C07C323/17 ,  C07C323/25 ,  C07C323/30 ,  C07C323/37 ,  C07C323/43 ,  C07C323/44 ,  C07C323/48 ,  C07C323/58 ,  C07C323/60 ,  C07D203/10 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/24 ,  C07D207/40 ,  C07D207/404 ,  C07D209/08 ,  C07D209/52 ,  C07D209/54 ,  C07D209/96 ,  C07D211/14 ,  C07D211/44 ,  C07D211/70 ,  C07D211/74 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/71 ,  C07D215/14 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D215/48 ,  C07D217/04 ,  C07D221/20 ,  C07D231/12 ,  C07D233/60 ,  C07D235/08 ,  C07D235/26 ,  C07D241/08 ,  C07D241/16 ,  C07D249/04 ,  C07D263/32 ,  C07D263/56 ,  C07D263/58 ,  C07D277/62 ,  C07D277/64 ,  C07D295/13 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/14 ,  C07D317/54 ,  C07D333/28 ,  C07D333/68 ,  C07D333/70 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D417/12 ,  C07D451/02 ,  C07D491/107

公开(公告)号：DE60020547D1

公开(公告)日：2005-07-07

申请号：DE60020547

申请日：2000-04-07

Applicant: ABBOTT LAB

Inventor： FESIK W ,  AUGERI J

IPC: C12N15/09 ,  C07B59/00 ,  C07C51/09 ,  C07C51/353 ,  C07C59/185 ,  C07C229/08 ,  C07K1/107 ,  C07K1/13 ,  C07K14/47 ,  C12N9/64 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P21/00 ,  C12P21/02

Abstract: Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with C or C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-( C)butyric acid and 2-keto-3-( C-methyl)-4-( C)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.

公开(公告)号：DE69615674D1

公开(公告)日：2001-11-08

申请号：DE69615674

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： ARENDSEN L ,  BAKER R ,  FAKHOURY A ,  FUNG L ,  GARVEY S ,  MCCLELLAN J ,  O'CONNOR J ,  PRASAD N ,  ROCKWAY W ,  ROSENBERG H ,  STEIN H ,  SHEN WANG ,  STOUT M ,  SULLIVAN M ,  AUGERI J

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K31/19 ,  A61K31/16

Abstract: The present invention provides a compound of formula (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.