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    1.
    发明专利
    未知

    公开(公告)号：DE69821475T3

    公开(公告)日：2009-07-23

    申请号：DE69821475

    申请日：1998-04-17

    Applicant: ABBOTT LAB

    Inventor： FESIK W ,  HAJDUK J ,  OLEJNICZAK T

    IPC: G01N24/08 ,  G01R33/32 ,  A61K45/00 ,  C07K14/705 ,  C12N9/00 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G01R33/44

    Abstract: The present invention provides a process for identifying compounds which bind to a specific target molecule. The process comprises the steps of: a) generating a first T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating a second T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed the target molecule in step (b); and d) comparing said first and second T2- or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.

    2.
    发明专利
    未知

    公开(公告)号：DE69606324T3

    公开(公告)日：2008-02-07

    申请号：DE69606324

    申请日：1996-11-13

    Applicant: ABBOTT LAB

    Inventor： FESIK W ,  HAJDUK J

    IPC: G01N33/50 ,  G01R33/465 ,  C12Q1/00 ,  G01N20060101 ,  G01N24/08 ,  G01N33/15 ,  G01N33/53 ,  G01N33/542 ,  G01N33/566 ,  G01N33/58 ,  G01N33/68

    Abstract: A method for designing and forming a ligand which binds to a specific target molecule comprises the steps of: (a) identifying a first ligand moiety that binds to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (b) identifying subsequent ligand moieties that bind to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (c) forming a complex of the first and subsequent ligand moieties to the target molecule; (d) determining the three-dimensional structure of the complex and, thus, the spatial orientation of the first and subsequent ligand moieties on the target molecule; and (e) linking the first and subsequent ligand moieties to form a new ligand to maintain the spatial orientation of the ligand moieties.

    3.
    发明专利
    未知

    公开(公告)号：DE60020547T2

    公开(公告)日：2006-05-04

    申请号：DE60020547

    申请日：2000-04-07

    Applicant: ABBOTT LAB

    Inventor： FESIK W ,  AUGERI J

    IPC: C07B59/00 ,  C12N15/09 ,  C07C51/09 ,  C07C51/353 ,  C07C59/185 ,  C07C229/08 ,  C07K1/107 ,  C07K1/13 ,  C07K14/47 ,  C12N9/64 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P21/00 ,  C12P21/02

    Abstract: Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with C or C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-( C)butyric acid and 2-keto-3-( C-methyl)-4-( C)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.

    8.
    发明专利
    未知

    公开(公告)号：DE69606324T2

    公开(公告)日：2000-07-06

    申请号：DE69606324

    申请日：1996-11-13

    Applicant: ABBOTT LAB

    Inventor： FESIK W ,  HAJDUK J

    IPC: G01R33/465 ,  C12Q1/00 ,  G01N20060101 ,  G01N24/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/542 ,  G01N33/566 ,  G01N33/58 ,  G01N33/68

    Abstract: A method for designing and forming a ligand which binds to a specific target molecule comprises the steps of: (a) identifying a first ligand moiety that binds to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (b) identifying subsequent ligand moieties that bind to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (c) forming a complex of the first and subsequent ligand moieties to the target molecule; (d) determining the three-dimensional structure of the complex and, thus, the spatial orientation of the first and subsequent ligand moieties on the target molecule; and (e) linking the first and subsequent ligand moieties to form a new ligand to maintain the spatial orientation of the ligand moieties.

    9.
    发明专利
    未知

    公开(公告)号：DE69606324D1

    公开(公告)日：2000-02-24

    申请号：DE69606324

    申请日：1996-11-13

    Applicant: ABBOTT LAB

    Inventor： FESIK W ,  HAJDUK J

    IPC: G01R33/465 ,  C12Q1/00 ,  G01N20060101 ,  G01N24/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/542 ,  G01N33/566 ,  G01N33/58 ,  G01N33/68

    Abstract: A method for designing and forming a ligand which binds to a specific target molecule comprises the steps of: (a) identifying a first ligand moiety that binds to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (b) identifying subsequent ligand moieties that bind to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (c) forming a complex of the first and subsequent ligand moieties to the target molecule; (d) determining the three-dimensional structure of the complex and, thus, the spatial orientation of the first and subsequent ligand moieties on the target molecule; and (e) linking the first and subsequent ligand moieties to form a new ligand to maintain the spatial orientation of the ligand moieties.

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