公开(公告)号：DE69615674D1

公开(公告)日：2001-11-08

申请号：DE69615674

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： ARENDSEN L ,  BAKER R ,  FAKHOURY A ,  FUNG L ,  GARVEY S ,  MCCLELLAN J ,  O'CONNOR J ,  PRASAD N ,  ROCKWAY W ,  ROSENBERG H ,  STEIN H ,  SHEN WANG ,  STOUT M ,  SULLIVAN M ,  AUGERI J

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K31/19 ,  A61K31/16

Abstract: The present invention provides a compound of formula (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：DE60117783T2

公开(公告)日：2006-11-30

申请号：DE60117783

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DALTON R ,  GIRANDA L ,  GONG JIANCHUN ,  MCCLELLAN J ,  NIENABER L ,  ROCKWAY W ,  SAUER R ,  WEITZBERG MOSHE

IPC: C07D217/02 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P15/16 ,  A61P15/18 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D217/04 ,  C07D217/06 ,  C07D217/26 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10

公开(公告)号：DE69615674T2

公开(公告)日：2002-07-11

申请号：DE69615674

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： ARENDSEN L ,  BAKER R ,  FAKHOURY A ,  FUNG L ,  GARVEY S ,  MCCLELLAN J ,  O'CONNOR J ,  PRASAD N ,  ROCKWAY W ,  ROSENBERG H ,  STEIN H ,  SHEN WANG ,  STOUT M ,  SULLIVAN M ,  AUGERI J

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K31/19 ,  A61K31/16

Abstract: The present invention provides a compound of formula (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：DE60118955T2

公开(公告)日：2007-01-04

申请号：DE60118955

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE K ,  GWALTNEY L ,  HASVOLD A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI A ,  ROCKWAY W ,  SHAM L ,  SULLIVAN M ,  TONG YUNSONG ,  WANG T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：DE60118955D1

公开(公告)日：2006-05-24

申请号：DE60118955

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE K ,  GWALTNEY L ,  HASVOLD A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI A ,  ROCKWAY W ,  SHAM L ,  SULLIVAN M ,  TONG YUNSONG ,  WANG T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：DE60117783D1

公开(公告)日：2006-05-04

申请号：DE60117783

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DALTON R ,  GIRANDA L ,  GONG JIANCHUN ,  MCCLELLAN J ,  NIENABER L ,  ROCKWAY W ,  SAUER R ,  WEITZBERG MOSHE

IPC: C07D217/02 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P15/16 ,  A61P15/18 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D217/04 ,  C07D217/06 ,  C07D217/26 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10