公开(公告)号：JP2011153148A

公开(公告)日：2011-08-11

申请号：JP2011049274

申请日：2011-03-07

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61P13/02 ,  A61P13/10 ,  A61P25/04 ,  A61P43/00 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D451/02 ,  C07D471/08

CPC classification number: C07D403/12 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating disorders selected from the group consisting of pain, bladder hyperactivity, urinary incontinence and inflammatory thermal hyperalgesia by inhibiting vanilloid receptor subtype 1 in mammals. SOLUTION: The pharmaceutical composition includes a new compound represented and exemplified by formula (XI) or a pharmaceutically acceptable salt etc., thereof. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供通过抑制哺乳动物中的香草素受体亚型1来提供用于治疗选自疼痛，膀胱多动症，尿失禁和炎症性热痛觉过敏的药物组合物。 解决方案：药物组合物包括由式（XI）表示和示例的新化合物或其药学上可接受的盐等。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：SI1658269T1

公开(公告)日：2009-04-30

申请号：SI200430995

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: C07D217/00 ,  A61K31/00 ,  A61P13/00 ,  A61P13/10 ,  C07C211/00 ,  C07D217/02 ,  C07D231/00 ,  C07D231/56 ,  C07D401/00 ,  C07D401/12 ,  C07D403/00 ,  C07D403/12

公开(公告)号：AU2010257277A1

公开(公告)日：2011-01-13

申请号：AU2010257277

申请日：2010-12-17

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  LEE CHIH-HUNG ,  CHAMBOURNIER GILLES ,  KOENIG JOHN R ,  LUKIN KIRILL ,  LEANNA M ROBERT ,  HSU MARGARET ,  SCHMIDT ROBERT ,  CINK RUSSEL D

IPC: A61P13/10 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：DE602004017329D1

公开(公告)日：2008-12-04

申请号：DE602004017329

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：ZA200509861B

公开(公告)日：2006-12-27

申请号：ZA200509861

申请日：2005-12-05

Applicant: ABBOTT LAB

Inventor： ARTHUR GOMTSYAN ,  CHIN-HUNG LEE ,  ROBERT SCHMIDT ,  GILLES CHAMBOUMIER ,  ROBERT LEANNA M ,  BAYBURT EROL K ,  KOENIG JOHN R ,  KIRILL LUKIN ,  MARGARET HSU ,  CINK RUSSEL D

IPC: A61K20090101 ,  A61P20090101 ,  C07C20090101 ,  C07D20090101 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：NZ590234A

公开(公告)日：2012-07-27

申请号：NZ59023404

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D ,  BAYBURT EROL K

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: A process for preparing a compound having structural formula (1*), wherein the substituents are as defined in the specification is disclosed, wherein process (1) is a process comprising, in toto, the steps of: (a) treating a compound of formula (XII) with trichloroacetyl chloride and triethylamine in dichloromethane to provide a compound of formula (la); and (b) treating the compound of formula (la) with a compound formula (XIII) (shown in the specification) and 1,8-diazabicycloundec-7-ene (DBU) in acetonitrile to provide a compound of formula (1*). Also disclosed are alternate processes for preparing a compound of formula (1*). These compounds of formula (1*) inhibit the VR1 receptor in mammals and are useful for controlling pain.

公开(公告)号：AU2004247721B2

公开(公告)日：2011-01-20

申请号：AU2004247721

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： HSU MARGARET ,  SCHMIDT ROBERT ,  BAYBURT EROL K ,  LUKIN KIRILL ,  LEANNA ROBERT M ,  LEE CHIH-HUNG ,  CHAMBOURNIER GILLES ,  CINK RUSSEL D ,  GOMTSYAN ARTHUR ,  KOENIG JOHN R

IPC: A61P13/10 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：NZ543713A

公开(公告)日：2009-08-28

申请号：NZ54371304

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  LEANNA M ROBERT ,  CINK RUSSEL D ,  HSU MARGARET

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: Disclosed are compounds of formula (I), wherein X5 is N, Z1 is O, Z2 is NH and the remaining substituents are as defined in the specification. The compounds inhibit the VR1 receptor in mammals and are useful for controlling pain.

公开(公告)号：HK1093727A1

公开(公告)日：2007-03-09

申请号：HK06112524

申请日：2006-11-14

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: A61K20090101 ,  A61P20090101 ,  A61P13/10 ,  C07C20090101 ,  C07D20090101 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：CY1111945T1

公开(公告)日：2015-11-04

申请号：CY111100738

申请日：2011-07-28

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA ROBERT M ,  CINK RUSSEL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: Ηπαρούσαεφεύρεσηγνωστοποιείνέεςενώσειςτουγενικούτύπου (I), ήέναφαρμακευτικώςαποδεκτόάλαςαυτών (στιςοποίες X1-Χ5, R5-R8b, Ζ1-Ζ2 καιΑr1 ορίζονταιστοπαρόν), φαρμακευτικέςσυνθέσειςοιοποίεςπεριλαμβάνουναυτέςτιςενώσειςκαιμιαδιαδικασίαγιαπαρασκευήαυτώντωνενώσεων. Οιενώσειςτουτύπου (I) είναιχρήσιμεςγιααντιμετώπισηάλγους, υπερδραστηριότηταςτηςουροδόχουκύστης, ουρικήςακράτειας, φλεγμονώδουςυπεραλγησίαςμέσωαναστολήςτου VR1 υποδοχέασεθηλαστικά.