公开(公告)号：DE69429827D1

公开(公告)日：2002-03-21

申请号：DE69429827

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： SUMMERS B ,  DAVIDSEN K ,  CURTIN L ,  HEYMAN ROBIN ,  SHEPPARD S ,  XU LIANHONG ,  CARRERA M ,  GARLAND B

IPC: C07D487/04 ,  A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：DE69429827T2

公开(公告)日：2002-11-21

申请号：DE69429827

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： SUMMERS B ,  DAVIDSEN K ,  CURTIN L ,  HEYMAN ROBIN ,  SHEPPARD S ,  XU LIANHONG ,  CARRERA M ,  GARLAND B

IPC: C07D487/04 ,  A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.