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公开(公告)号：DE69429827D1
公开(公告)日：2002-03-21
申请号：DE69429827
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS B , DAVIDSEN K , CURTIN L , HEYMAN ROBIN , SHEPPARD S , XU LIANHONG , CARRERA M , GARLAND B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/50
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：DE69627380T2
公开(公告)日：2004-03-25
申请号：DE69627380
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： FESIK W , SUMMERS B , DAVIDSEN K , SHEPPARD S , STEINMAN H , CARRERA M , FLORJANCIC ALAN , HOLMS H
IPC: A61P19/02 , A61K31/185 , A61K31/275 , A61P29/00 , A61P35/04 , A61P43/00 , C07C259/06 , C07C323/60 , A61K31/16
Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
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公开(公告)号：DE69429827T2
公开(公告)日：2002-11-21
申请号：DE69429827
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS B , DAVIDSEN K , CURTIN L , HEYMAN ROBIN , SHEPPARD S , XU LIANHONG , CARRERA M , GARLAND B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/50
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：DE69627380D1
公开(公告)日：2003-05-15
申请号：DE69627380
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： FESIK W , SUMMERS B , DAVIDSEN K , SHEPPARD S , STEINMAN H , CARRERA M , FLORJANCIC ALAN , HOLMS H
IPC: A61P19/02 , A61K31/185 , A61K31/275 , A61P29/00 , A61P35/04 , A61P43/00 , C07C259/06 , C07C323/60 , A61K31/16
Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
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公开(公告)号：DE69615676T2
公开(公告)日：2002-07-11
申请号：DE69615676
申请日：1996-03-25
Applicant: ABBOTT LAB
Inventor： SHEPPARD S , DAVIDSON K , SUMMERS B , CARRERA M
IPC: C07D403/12 , A61K31/435 , A61P7/02 , C07D471/04
Abstract: The present invention provides compounds of formula +TR and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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Patent Agency Ranking
公开(公告)号：DE69615676D1
公开(公告)日：2001-11-08
申请号：DE69615676
申请日：1996-03-25
Applicant: ABBOTT LAB
Inventor： SHEPPARD S , DAVIDSON K , SUMMERS B , CARRERA M
IPC: C07D403/12 , A61K31/435 , A61P7/02 , C07D471/04
Abstract: The present invention provides compounds of formula +TR and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：DE69934113T2
公开(公告)日：2007-06-06
申请号：DE69934113
申请日：1999-05-21
Applicant: ABBOTT LAB
Inventor： KAWAI MEGUMI , HENKIN JACK , SHEPPARD S , CRAIG A
IPC: C07C237/42 , C07D213/82 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/223 , A61K31/245 , A61K31/4406 , A61P27/02 , A61P29/02 , A61P35/00 , C07C237/22 , C07C311/45 , C07C311/46
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公开(公告)号：DE60106740T2
公开(公告)日：2006-03-02
申请号：DE60106740
申请日：2001-04-13
Applicant: ABBOTT LAB
Inventor： CRAIG A , KAWAI MEGUMI , LYNCH M , PATEL R , SHEPPARD S , WANG JIEYI , YANG FAN , BA-MAUNG Y
IPC: C07D295/14 , A61K31/15 , A61K31/164 , A61K31/165 , A61K31/175 , A61K31/18 , A61K31/215 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/435 , A61K31/4402 , A61K31/4409 , A61K31/455 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/5375 , A61P9/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C239/20 , C07C243/28 , C07C243/34 , C07C243/38 , C07C251/86 , C07C255/42 , C07C255/66 , C07C259/06 , C07C281/02 , C07C281/06 , C07C311/37 , C07C311/38 , C07C321/14 , C07C323/12 , C07C323/18 , C07C323/41 , C07C323/60 , C07C323/62 , C07D207/34 , C07D207/40 , C07D207/416 , C07D207/50 , C07D209/20 , C07D211/12 , C07D211/62 , C07D213/38 , C07D213/54 , C07D213/75 , C07D213/77 , C07D213/86 , C07D213/87 , C07D215/42 , C07D215/46 , C07D231/14 , C07D231/38 , C07D237/14 , C07D237/20 , C07D237/24 , C07D239/28 , C07D239/42 , C07D241/24 , C07D241/44 , C07D261/18 , C07D277/20 , C07D277/36 , C07D277/56 , C07D277/82 , C07D295/15 , C07D295/20 , C07D295/32 , C07D307/24 , C07D307/56 , C07D307/68 , C07D307/85 , C07D311/04 , C07D317/68 , C07D319/08 , C07D333/38 , C07D333/40 , C07D333/68 , C07D333/72
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公开(公告)号：DE69934113D1
公开(公告)日：2007-01-04
申请号：DE69934113
申请日：1999-05-21
Applicant: ABBOTT LAB
Inventor： KAWAI MEGUMI , HENKIN JACK , SHEPPARD S , CRAIG A
IPC: C07C237/42 , C07D213/82 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/223 , A61K31/245 , A61K31/4406 , A61P27/02 , A61P29/02 , A61P35/00 , C07C237/22 , C07C311/45 , C07C311/46
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公开(公告)号：DE60106740D1
公开(公告)日：2004-12-02
申请号：DE60106740
申请日：2001-04-13
Applicant: ABBOTT LAB
Inventor： CRAIG A , KAWAI MEGUMI , LYNCH M , PATEL R , SHEPPARD S , WANG JIEYI , YANG FAN , BA-MAUNG Y
IPC: C07D295/14 , A61K31/15 , A61K31/164 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4409 , A61K31/455 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/5375 , A61P9/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C243/28 , C07C243/34 , C07C243/38 , C07C251/86 , C07C255/42 , C07C255/66 , C07C259/06 , C07C281/02 , C07C281/06 , C07C311/37 , C07C311/38 , C07C323/12 , C07C323/18 , C07C323/41 , C07C323/60 , C07C323/62 , C07D207/34 , C07D207/40 , C07D207/416 , C07D207/50 , C07D209/20 , C07D211/12 , C07D211/62 , C07D213/38 , C07D213/54 , C07D213/77 , C07D213/86 , C07D213/87 , C07D215/42 , C07D231/14 , C07D231/38 , C07D237/14 , C07D237/20 , C07D237/24 , C07D239/28 , C07D239/42 , C07D241/24 , C07D241/44 , C07D261/18 , C07D277/20 , C07D277/36 , C07D277/56 , C07D277/82 , C07D295/15 , C07D295/20 , C07D295/32 , C07D307/24 , C07D307/56 , C07D307/68 , C07D307/85 , C07D311/04 , C07D317/68 , C07D319/08 , C07D333/38 , C07D333/40 , C07D333/68 , C07D333/72 , A61K31/175 , A61K31/435 , C07C239/20 , C07C321/14 , C07D213/75 , C07D215/46
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