公开(公告)号：DE69627380D1

公开(公告)日：2003-05-15

申请号：DE69627380

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK W ,  SUMMERS B ,  DAVIDSEN K ,  SHEPPARD S ,  STEINMAN H ,  CARRERA M ,  FLORJANCIC ALAN ,  HOLMS H

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.

公开(公告)号：DE60000819D1

公开(公告)日：2003-01-02

申请号：DE60000819

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN L ,  DAI YUJIA ,  DAVIDSEN K ,  HEYMAN R ,  HOLMES H ,  MICHAELIDES R ,  STEINMAN H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：DE60000819T2

公开(公告)日：2003-09-04

申请号：DE60000819

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN L ,  DAI YUJIA ,  DAVIDSEN K ,  HEYMAN R ,  HOLMES H ,  MICHAELIDES R ,  STEINMAN H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：DE69429827D1

公开(公告)日：2002-03-21

申请号：DE69429827

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： SUMMERS B ,  DAVIDSEN K ,  CURTIN L ,  HEYMAN ROBIN ,  SHEPPARD S ,  XU LIANHONG ,  CARRERA M ,  GARLAND B

IPC: C07D487/04 ,  A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：DE69627380T2

公开(公告)日：2004-03-25

申请号：DE69627380

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK W ,  SUMMERS B ,  DAVIDSEN K ,  SHEPPARD S ,  STEINMAN H ,  CARRERA M ,  FLORJANCIC ALAN ,  HOLMS H

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.

公开(公告)号：DE69429827T2

公开(公告)日：2002-11-21

申请号：DE69429827

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： SUMMERS B ,  DAVIDSEN K ,  CURTIN L ,  HEYMAN ROBIN ,  SHEPPARD S ,  XU LIANHONG ,  CARRERA M ,  GARLAND B

IPC: C07D487/04 ,  A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.