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公开(公告)号：DE60000819D1
公开(公告)日：2003-01-02
申请号：DE60000819
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN L , DAI YUJIA , DAVIDSEN K , HEYMAN R , HOLMES H , MICHAELIDES R , STEINMAN H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：DE69429827T2
公开(公告)日：2002-11-21
申请号：DE69429827
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS B , DAVIDSEN K , CURTIN L , HEYMAN ROBIN , SHEPPARD S , XU LIANHONG , CARRERA M , GARLAND B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/50
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：DE60000819T2
公开(公告)日：2003-09-04
申请号：DE60000819
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN L , DAI YUJIA , DAVIDSEN K , HEYMAN R , HOLMES H , MICHAELIDES R , STEINMAN H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：DE69429827D1
公开(公告)日：2002-03-21
申请号：DE69429827
申请日：1994-12-08
Applicant: ABBOTT LAB
Inventor： SUMMERS B , DAVIDSEN K , CURTIN L , HEYMAN ROBIN , SHEPPARD S , XU LIANHONG , CARRERA M , GARLAND B
IPC: C07D487/04 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/505 , A61P7/02 , A61P11/00 , A61P11/16 , A61P17/00 , A61P29/00 , A61P37/08 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/50
Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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