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    LIGAND ANALOG-IRREVERSIBLE ENZYME INHIBITOR CONJUGATES AND METHODS FOR USE
    1.
    发明专利
    LIGAND ANALOG-IRREVERSIBLE ENZYME INHIBITOR CONJUGATES AND METHODS FOR USE 未知

    公开(公告)号：CA1137077A

    公开(公告)日：1982-12-07

    申请号：CA343676

    申请日：1980-01-15

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON F ,  PLATTNER JACOB ,  HERRIN THOMAS R

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  C07J41/00

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present invention are particularly useful in determining drugs, hormones, and the like in biological fluids.

    2-HALO-6-O-SUBSTITUTED KETOLIDE DERIVATIVES
    2.
    发明专利
    2-HALO-6-O-SUBSTITUTED KETOLIDE DERIVATIVES 未知

    公开(公告)号：BG64707B1

    公开(公告)日：2005-12-30

    申请号：BG10443400

    申请日：2000-05-15

    Applicant: ABBOTT LAB

    Inventor： PHAN LY ,  OR YAT SUN ,  CHU DANIEL ,  PLATTNER JACOB ,  CHEN YAN ,  CLARK RICHARD

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    Abstract: The invention relates to novel 2-halo-6-O-substituted ketolide derivatives with the formula to their pharmaceutically acceptable salts having antibacterial activity, to pharmaceutical compositions comprising a therapeutically effective amount of a compound according to the invention in combination with a pharmaceutically acceptable carrier, as well as to the utilization of the compounds or their pharmaceutically acceptable salt for the preparation of a medicament for treating bacterial infections in mammals. The invention also relates to the preparation of the compounds.

    LIGAND ANALOGUE - IRRIVERSIBLE ENZYME INHIBITOR CONJUGATES
    3.
    发明专利
    LIGAND ANALOGUE - IRRIVERSIBLE ENZYME INHIBITOR CONJUGATES 未知

    公开(公告)号：AU5476380A

    公开(公告)日：1980-08-14

    申请号：AU5476380

    申请日：1980-01-21

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  HERRIN THOMAS RAYMOND ,  PLATTNER JACOB

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  C07G17/00 ,  C12Q1/00 ,  C07J41/00 ,  C07H15/22 ,  C07F9/65 ,  C07J43/00 ,  C07H23/00

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

    5.
    发明专利
    未知

    公开(公告)号：IT1130254B

    公开(公告)日：1986-06-11

    申请号：IT1967580

    申请日：1980-02-04

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  PLATTNER JACOB ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  G01N

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

    LIGAND ANALOGUE - IRRIVERSIBLE ENZYME INHIBITOR CONJUGATES
    7.
    发明专利
    LIGAND ANALOGUE - IRRIVERSIBLE ENZYME INHIBITOR CONJUGATES 未知

    公开(公告)号：AU528592B2

    公开(公告)日：1983-05-05

    申请号：AU5476380

    申请日：1980-01-21

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  PLATTNER JACOB ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  C07F9/65 ,  C07G17/00 ,  C07H15/22 ,  C07H23/00 ,  C07J41/00 ,  C07J43/00 ,  C12Q1/00 ,  G01N33/54

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

    8.
    发明专利
    未知

    公开(公告)号：DE3003959A1

    公开(公告)日：1980-08-14

    申请号：DE3003959

    申请日：1980-02-04

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  PLATTNER JACOB ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  C07F9/201 ,  G01N33/16 ,  C07F9/65

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

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