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    DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID
    1.
    发明申请
    DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID 审中-公开
    诊断测定需要生物流体的小样本

    公开(公告)号：WO9964620A3

    公开(公告)日：2001-01-18

    申请号：PCT/US9912294

    申请日：1999-06-03

    Applicant: ABBOTT LAB

    Inventor： WONG SIE TING ,  HILTIBRAN ROBERT G ,  HUANG TUNG-MING

    IPC: G01N33/52 ,  C12Q1/32 ,  C12Q1/54 ,  G01N33/53 ,  G01N33/543 ,  G01N33/66 ,  G01N37/00

    CPC classification number: G01N33/54373 ,  G01N33/5304

    Abstract: A multiple-layer element method for monitoring the concentration of glucose in blood. The element comprises: (a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of said two major surfaces to a second opening in the other of said two major surfaces, said, core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chamber; and (b) a base layer in face-to-face contact with one major surface of said core layer; and (c) a cover layer in face-to-face contact with the other major surface of said core layer, said cover layer having an opening therein to vent the element. The method involves (a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient; (b) introducing the sample to article comprising a multiple-layer element having an optical reading chamber; (c) allowing reagents to react with an analyse of interest in the sample; and (d) measuring the concentration of analyse in the sample by means of an optical instrument.

    Abstract translation: 用于监测血液中葡萄糖浓度的多层元素法。 元件包括：（a）具有两个主表面的芯层，从所述两个主表面之一中的一个中的第一个开口延伸到所述两个主表面中另一个中的第二开口的光学读取室，所述芯层还具有 第三开口和流路，其一端与第三开口连通，另一端与光读出室连通; 和（b）与所述芯层的一个主表面面对面接触的基底层; 和（c）与所述芯层的另一个主表面面对面接触的覆盖层，所述覆盖层在其中具有用于排出元件的开口。 该方法包括（a）从患者的身体获得生物流体样品，例如间质液; （b）将样品引入包括具有光学读取室的多层元件的制品; （c）允许试剂与样品中的兴趣分析反应; 和（d）通过光学仪器测量样品中的分析浓度。

    2.
    发明专利
    未知

    公开(公告)号：ES2187165T3

    公开(公告)日：2003-05-16

    申请号：ES99927176

    申请日：1999-06-03

    Applicant: ABBOTT LAB

    Inventor： WONG SIE TING ,  HILTIBRAN ROBERT G ,  HUANG TUNG-MING

    IPC: G01N33/52 ,  C12Q1/32 ,  C12Q1/54 ,  G01N33/53 ,  G01N33/543 ,  G01N33/66 ,  G01N37/00

    Abstract: An article and a method for monitoring the concentration of glucose in blood. In one aspect, the invention involves an article comprising a multiple-layer element utilizing reagents capable of reacting with an analyte of interest. In a preferred embodiment, the element comprises: (a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of the two major surfaces to a second opening in the other of the two major surfaces, the core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chamber; (b) a base layer in face-to-face contact with one major surface of the core layer; and (c) a cover layer in face-to-face contact with the other major surface of the core layer, the cover layer having an opening therein to vent the element. In another aspect, the invention involves a method comprising the steps of: (a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient; (b) introducing the sample to an article comprising a multiple-layer element having an optical reading chamber; (c) allowing reagents to react with an analyte of interest in the sample; and (d) measuring the concentration of analyte in the sample by means of an optical instrument.

    DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID
    4.
    发明专利
    DIAGNOSTIC ASSAY REQUIRING A SMALL SAMPLE OF BIOLOGICAL FLUID 未知

    公开(公告)号：CA2334269A1

    公开(公告)日：1999-12-16

    申请号：CA2334269

    申请日：1999-06-03

    Applicant: ABBOTT LAB

    Inventor： WONG SIE TING ,  HUANG TUNG-MING ,  HILTIBRAN ROBERT G

    IPC: G01N33/52 ,  C12Q1/32 ,  C12Q1/54 ,  G01N33/53 ,  G01N33/543 ,  G01N33/66 ,  G01N37/00

    Abstract: A multiple-layer element method for monitoring the concentration of glucose in blood. The element comprises: (a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of said two major surfaces to a second opening in the other of said two major surfaces, said, core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chambe r; and (b) a base layer in face-to-face contact with one major surface of said core layer; and (c) a cover layer in face-to-face contact with the other maj or surface of said core layer, said cover layer having an opening therein to ve nt the element. The method involves (a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient; (b) introducing the sample to article comprising a multiple-layer element having an optical reading chamber; (c) allowing reagents to react with an analyse of interest in the sample; and (d) measuring the concentration of analyse in the sample by means of an optical instrument.

    ION-CAPTURE ASSAYS AND DEVICES
    5.
    发明专利
    ION-CAPTURE ASSAYS AND DEVICES 未知

    公开(公告)号：AU2866089A

    公开(公告)日：1989-08-03

    申请号：AU2866089

    申请日：1989-01-20

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  JOU YI-HER ,  KLINE STEVEN J ,  SCHULTZ STEVEN GEORGE ,  STROUPE STEPHEN DENHAM

    IPC: G01N33/532 ,  G01N33/538 ,  G01N33/543 ,  G01N33/574 ,  G01N33/68 ,  C07K17/00 ,  G01N33/74 ,  G01N33/76

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

    7.
    发明专利
    未知

    公开(公告)号：ES2016070T3

    公开(公告)日：1997-01-16

    申请号：ES89101263

    申请日：1989-01-25

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  JOU YI-HER ,  KLINE STEVEN J ,  SCHULTZ STEVEN GEORGE ,  STROUPE STEPHEN DENHAM

    IPC: G01N33/532 ,  G01N33/538 ,  G01N33/543 ,  G01N33/574 ,  G01N33/537

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

    8.
    发明专利
    未知

    公开(公告)号：ES2080056T3

    公开(公告)日：1996-02-01

    申请号：ES89114103

    申请日：1989-07-31

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  STROUPE STEPHEN DENHAM ,  JOU YI-HER

    IPC: G01N33/532 ,  C07K14/435 ,  C07K14/76 ,  C08G69/10 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N33/574

    Abstract: This invention presents novel polymeric anionic molecules and novel negatively charged capture reagents comprising the reaction products of said anionic molecules and a specific binding member for use in separation techniques and assay procedures wherein said activated polymeric anionic molecule comprises a compound having the formula: wherein n is about 10 to about 500; z is about 1 to about 6; W is selected from the group consisting of H , Na , K , Li , amine salts, and derivatives thereof; and X is a reactive group or a structure having a reactive group that enables the chemical binding of said activated polymer to a specific binding member.

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