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    ION-CAPTURE ASSAYS AND DEVICES
    3.
    发明专利
    ION-CAPTURE ASSAYS AND DEVICES 未知

    公开(公告)号：AU2866089A

    公开(公告)日：1989-08-03

    申请号：AU2866089

    申请日：1989-01-20

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  JOU YI-HER ,  KLINE STEVEN J ,  SCHULTZ STEVEN GEORGE ,  STROUPE STEPHEN DENHAM

    IPC: G01N33/532 ,  G01N33/538 ,  G01N33/543 ,  G01N33/574 ,  G01N33/68 ,  C07K17/00 ,  G01N33/74 ,  G01N33/76

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

    4.
    发明专利
    未知

    公开(公告)号：DE68927118T2

    公开(公告)日：1997-04-10

    申请号：DE68927118

    申请日：1989-01-25

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  JOU YI-HER ,  KLINE STEVEN J ,  SCHULTZ STEVEN GEORGE ,  STROUPE STEPHEN DENHAM

    IPC: G01N33/532 ,  G01N33/538 ,  G01N33/543 ,  G01N33/574 ,  G01N33/537

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

    ION CAPTURE ASSAYS AND DEVICES
    5.
    发明专利
    ION CAPTURE ASSAYS AND DEVICES 未知

    公开(公告)号：CA1338928C

    公开(公告)日：1997-02-25

    申请号：CA589397

    申请日：1989-01-27

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  JOU YI-HER ,  KLINE STEVEN J ,  SCHULTZ STEVEN GEORGE ,  STROUPE STEPHEN DENHAM

    IPC: G01N33/532 ,  G01N33/538 ,  G01N33/543 ,  G01N33/574 ,  G01N33/544

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowedimmunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-specific binding substance which is conjugated to a label capable of producing adetectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

    8.
    发明专利
    未知

    公开(公告)号：DE68927118D1

    公开(公告)日：1996-10-17

    申请号：DE68927118

    申请日：1989-01-25

    Applicant: ABBOTT LAB

    Inventor： HILTIBRAN ROBERT G ,  JOU YI-HER ,  KLINE STEVEN J ,  SCHULTZ STEVEN GEORGE ,  STROUPE STEPHEN DENHAM

    IPC: G01N33/532 ,  G01N33/538 ,  G01N33/543 ,  G01N33/574 ,  G01N33/537

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

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