公开(公告)号：DE69627380D1

公开(公告)日：2003-05-15

申请号：DE69627380

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK W ,  SUMMERS B ,  DAVIDSEN K ,  SHEPPARD S ,  STEINMAN H ,  CARRERA M ,  FLORJANCIC ALAN ,  HOLMS H

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.

公开(公告)号：DE69627380T2

公开(公告)日：2004-03-25

申请号：DE69627380

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK W ,  SUMMERS B ,  DAVIDSEN K ,  SHEPPARD S ,  STEINMAN H ,  CARRERA M ,  FLORJANCIC ALAN ,  HOLMS H

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.