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公开(公告)号：WO03090666A2
公开(公告)日：2003-11-06
申请号：PCT/EP0304900
申请日：2003-04-25
Applicant: KAROBIO AB , ABBOTT LAB , JAKOB CLARISSA G , MUCHMORE STEVEN , KAUPPI BJOERN , FARNEGAARDH MATHIAS , HARLAN JOHN E , YANG JIE , CARLQUIST MATS , ENGSTROEM OWE , AHOLA HARRI , OEHMAN LARS
Inventor： JAKOB CLARISSA G , MUCHMORE STEVEN , KAUPPI BJOERN , FARNEGAARDH MATHIAS , HARLAN JOHN E , YANG JIE , CARLQUIST MATS , ENGSTROEM OWE , AHOLA HARRI , OEHMAN LARS
IPC: A61K20060101 , C07K14/72 , G01N33/48 , G06F19/00 , A61K
Abstract: The present invention is in the fields of biotechnology, protein purification and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modeling and rational drug design. The invention is directed to the glucocorticoid receptor and ligands for this receptor, and in particular to crystalline glucocorticoid receptor (GR) and to methods of identifying ligands utilizing GR, as well as to compounds, compositions and methods for selecting, making, and using therapeutic or diagnostic agents having GR modulating or binding activity.
Abstract translation: 本发明涉及生物技术，蛋白质纯化和结晶，X射线衍射分析，三维计算机分子建模和合理药物设计领域。 本发明涉及用于该受体的糖皮质激素受体和配体，特别是结晶糖皮质激素受体（GR）和鉴定使用GR的配体的方法，以及用于选择，制备和使用治疗的化合物，组合物和方法 或具有GR调节或结合活性的诊断剂。
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公开(公告)号：AU2009322236A1
公开(公告)日：2011-06-23
申请号：AU2009322236
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： JAKOB CLARISSA G , CHENGBIN WU , WALTER KARL A , TARIQ GHAYUR
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：AU2003233315A8
公开(公告)日：2003-11-10
申请号：AU2003233315
申请日：2003-04-25
Applicant: ABBOTT LAB , KAROBIO AB
Inventor： ENGSTROM OWE , AHOLA HARRI , OHMAN LARS , JAKOB CLARISSA G , MUCHMORE STEVEN , KAUPPI BJORN , FARNEGARDH MATHIAS , HARLAN JOHN E , YANG JIE , CARLQUIST MATS
IPC: A61K20060101 , C07K14/72 , G01N33/48 , G06F19/00
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Patent Agency Ranking
公开(公告)号：NZ593314A
公开(公告)日：2013-03-28
申请号：NZ59331409
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： JAKOB CLARISSA G
Abstract: Disclosed are engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. The Antibodies are created using a predefined framework region.
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公开(公告)号：SG171812A1
公开(公告)日：2011-07-28
申请号：SG2011037769
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： JAKOB CLARISSA G , WU CHENGBIN , WALTER KARL A , GHAYUR TARIQ
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：BRPI0922807A2
公开(公告)日：2015-12-22
申请号：BRPI0922807
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , JAKOB CLARISSA G , WALTER KARL A , GHAYUR TARIQ
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公开(公告)号：MX2011005953A
公开(公告)日：2011-08-17
申请号：MX2011005953
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , JAKOB CLARISSA G , WALTER KARL A
Abstract: La presente invención se refiere a proteínas de unión multivalentes y multiespecíficas diseñadas, métodos para hacerlas, y específicamente a sus usos en la prevención, diagnóstico y/o tratamiento de enfermedad.
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公开(公告)号：CA2745271A1
公开(公告)日：2010-06-10
申请号：CA2745271
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： JAKOB CLARISSA G , WU CHENGBIN , WALTER KARL A , GHAYUR TARIQ
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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