公开(公告)号：WO9945105A2

公开(公告)日：1999-09-10

申请号：PCT/US9904992

申请日：1999-03-05

Applicant: ABBOTT LAB

Inventor： WANG JIEYI ,  NIENABER VICKI L ,  HENKIN JACK ,  SMITH RICHARD A ,  WALTER KARL A ,  SEVERIN JEAN M ,  EDALJI ROHINTON ,  JOHNSON ROBERT W JR ,  HOLZMAN THOMAS

IPC: C12N15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/50 ,  C12N9/72 ,  C12N9/00

CPC classification number: C12N9/6462 ,  C12Y304/21073

Abstract: The present disclosure describes a biologically active modified urokinase and high resolution crystalline forms of modified urokinase. Polynucleotides which encode modified urokinase and methods for making modified urokinase are also disclosed.

Abstract translation: 本公开描述了生物活性修饰尿激酶和修饰尿激酶的高分辨率晶体形式。 还公开了编码改变的尿激酶的多核苷酸和制备修饰尿激酶的方法。

公开(公告)号：AU2009322236A1

公开(公告)日：2011-06-23

申请号：AU2009322236

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： JAKOB CLARISSA G ,  CHENGBIN WU ,  WALTER KARL A ,  TARIQ GHAYUR

IPC: C07K16/46 ,  A61K39/00

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：CA2322622A1

公开(公告)日：1999-09-10

申请号：CA2322622

申请日：1999-03-05

Applicant: ABBOTT LAB

Inventor： WALTER KARL A ,  SMITH RICHARD A ,  EDALJI ROHINTON ,  SEVERIN JEAN M ,  WANG JIEYI ,  JOHNSON ROBERT W JR ,  NIENABER VICKI L ,  HENKIN JACK ,  HOLZMAN THOMAS

IPC: C12N15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/50 ,  C12N9/72 ,  C12N15/58 ,  C12N15/86 ,  C12P21/02

Abstract: The present disclosure describes a biologically active modified urokinase and high resolution crystalline forms of modified urokinase. Polynucleotides which encode modified urokinase and methods for making modified urokinase are also disclosed.

公开(公告)号：BRPI0922807A2

公开(公告)日：2015-12-22

申请号：BRPI0922807

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  JAKOB CLARISSA G ,  WALTER KARL A ,  GHAYUR TARIQ

IPC: C07K16/46 ,  A61K39/00

公开(公告)号：MX2011005953A

公开(公告)日：2011-08-17

申请号：MX2011005953

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  GHAYUR TARIQ ,  JAKOB CLARISSA G ,  WALTER KARL A

IPC: C07K16/46 ,  A61K39/00

Abstract: La presente invención se refiere a proteínas de unión multivalentes y multiespecíficas diseñadas, métodos para hacerlas, y específicamente a sus usos en la prevención, diagnóstico y/o tratamiento de enfermedad.

公开(公告)号：CA2745271A1

公开(公告)日：2010-06-10

申请号：CA2745271

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： JAKOB CLARISSA G ,  WU CHENGBIN ,  WALTER KARL A ,  GHAYUR TARIQ

IPC: C07K16/46 ,  A61K39/395 ,  C07K16/00 ,  C12N15/00 ,  C12N15/13 ,  G01N33/53 ,  G01N33/68

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：SG171812A1

公开(公告)日：2011-07-28

申请号：SG2011037769

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： JAKOB CLARISSA G ,  WU CHENGBIN ,  WALTER KARL A ,  GHAYUR TARIQ

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.