公开(公告)号：BRPI0910482A2

公开(公告)日：2019-09-24

申请号：BRPI0910482

申请日：2009-04-28

Applicant: ABBOTT LAB

Inventor： ANDREW PHILLIPS ,  EDWARD B REILLY ,  GILLIAN A KINGSBURY ,  HUA YING ,  JIEYI WANG ,  JUNJIAN LIU ,  RANDY L BELL ,  SUSAN E MORGAN-LAPPEN ,  SUZANNE M NORVELL ,  TARIQ GHAYUR ,  YINGCHUN LI

IPC: A61K39/00

公开(公告)号：AU2010242830A1

公开(公告)日：2011-12-15

申请号：AU2010242830

申请日：2010-04-30

Applicant: ABBOTT LAB

Inventor： TARIQ GHAYUR ,  JUNJIAN LIU ,  KINGSBURY GILLIAN A ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN E

IPC: A61K39/395 ,  A61K39/00 ,  C12P21/06 ,  C12P21/08

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：AU2011224023A1

公开(公告)日：2011-10-06

申请号：AU2011224023

申请日：2011-09-13

Applicant: ABBOTT LAB

Inventor： BORIS LABKOVSKY ,  BRAD HEDBERG ,  JAMES WIELER ,  SINGH KANG JASPAL ,  XIAO-CHI JIA ,  JOHN BADCOOK ,  LARRY GREEN ,  TARIQ GHAYUR ,  VOSS JEFFERY W

IPC: C07K16/24 ,  G01N33/68

Abstract: IL -18 BINDING PRO TEINS Abstract The present invention encompasses IL-1 8 binding proteins, particularly antibodies that bind human interleukin- 18 (hIL- 18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hlL-18 and/or that neutralize hIL-1 8 activity in vitro and in vivo. An antibody of the io invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hlL- 18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hlL 18 activity is detrimental.

公开(公告)号：UY32948A

公开(公告)日：2011-02-28

申请号：UY32948

申请日：2010-10-15

Applicant: ABBOTT LAB

Inventor： TARIQ GHAYUR ,  KAMATH RAJESH V ,  LIU JUNJIAN ,  HONORE MARIE P

IPC: A61K39/395 ,  C07K16/22 ,  C07K16/24 ,  C07K16/46 ,  C07K19/00 ,  C12N5/10 ,  C12N15/13 ,  C12N15/62

Abstract: Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para su obtención y específicamente sus usos en la prevención, diagnóstico y/o tratamiento de enfermedades.

公开(公告)号：CR11837A

公开(公告)日：2011-01-12

申请号：CR11837

申请日：2010-12-09

Applicant: ABBOTT LAB

Inventor： TARIQ GHAYUR ,  PETER C ISAKSON ,  LISA M OLSON ,  CHENGBIN WU ,  MARGARET HUGUNIN ,  RAJESH V KAMATH ,  CAROLYN A CUFF ,  HAMISH J ALLEN

IPC: A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  C12N1/10 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63

Abstract: Proteínas de unión multivalentes y multiespecíficas producidas por ingeniería genética, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.

公开(公告)号：BRPI0913406A2

公开(公告)日：2018-01-09

申请号：BRPI0913406

申请日：2009-06-03

Applicant: ABBOTT LAB

Inventor： CAROLYN A CUFF ,  CHENGBIN WU ,  HAMISH J ALLEN ,  LISA M OLSON ,  MARGARET HUGUNIN ,  PETER C ISAKSON ,  RAJESH V KAMATH ,  TARIQ GHAYUR

IPC: C07K16/46 ,  C07K16/20 ,  C12P21/08

公开(公告)号：GT201200058A

公开(公告)日：2014-01-28

申请号：GT201200058

申请日：2012-03-01

Applicant: ABBOTT LAB

Inventor： TARIQ GHAYUR ,  JUNJIAN LIU ,  SHARMILA MANOJ ,  BROPHY SUSAN E

IPC: A61K51/00 ,  A61K39/395 ,  C07K16/00

Abstract: LA PRESENTE INVENCIÓN SE REFIERE A PROTEÍNASDE UNIÓN MULTIVALENTES Y MULTIESPECÍFICAS PRODUCIDAS POR INGENIERÍA GENÉTICA, MÉTODOS PARA ELABORARLAS Y ESPECÍFICAMENTE, SUS USOS EN LA PREVENCIÓN, EL DIAGNÓSTICO Y/O EL TRATAMIENTO DE ENFERMEDADES.

公开(公告)号：UY33702A

公开(公告)日：2012-05-31

申请号：UY33702

申请日：2011-11-01

Applicant: ABBOTT LAB

Inventor： JUNJIAN LIU ,  TARIQ GHAYUR ,  HARRIS MARIA C ,  JIJIE GU

IPC: C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/12 ,  C12N15/70 ,  C12N15/79

Abstract: Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para elaborarlas y sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.

公开(公告)号：AU2009322236A1

公开(公告)日：2011-06-23

申请号：AU2009322236

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： JAKOB CLARISSA G ,  CHENGBIN WU ,  WALTER KARL A ,  TARIQ GHAYUR

IPC: C07K16/46 ,  A61K39/00

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：ZA200603733B

公开(公告)日：2007-10-31

申请号：ZA200603733

申请日：2006-05-10

Applicant: ABBOTT LAB

Inventor： TARIQ GHAYUR ,  VOSS JEFFREY W ,  JOHN BABCOOK ,  JAMES WIELER ,  BRAD HEDBERG ,  BORIS LABKOVSKY ,  LARRY GREEN ,  XIAO-CHI JIA ,  SINGH KANG JASPAL

IPC: C07K20090101 ,  C07K16/24 ,  G01N33/68

Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.