公开(公告)号：JP2007151618A

公开(公告)日：2007-06-21

申请号：JP2005347194

申请日：2005-11-30

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  JENG TZYY-WEN ,  YEH SHU-JEN

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: PROBLEM TO BE SOLVED: To pursue temperature-induced glycolysis in the noninvasive measurement of glucose. SOLUTION: The change of glucose metabolism inside a skin nutrition capillary tube is induced, the change of localized reflectance optical signals in a plurality of distances between a light source and a detector and a plurality of wavelengths is measured as the function of the time of bringing a probe into contact with the skin, a time window capable of minimizing the influence of tissue and probe adaptation on signals is selected, and also the signals measured within the time window are used for the following calculation. One set of functions is calculated from a plurality of localized reflectance values in the plurality of distances between the light source and the detector and the plurality of wavelengths at a plurality of time intervals in at least two wavelengths within the time window, calibration relation between the combination of calculation functions and the glucose concentration of a living body is derived, and the calibration relation is used in order to predict the glucose concentration in body liquid in the following measurement. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：在葡萄糖的无创测量中追求温度诱导的糖酵解。 解决方案：诱导皮肤营养毛细管内的葡萄糖代谢的变化，测量光源和检测器之间的多个距离和多个波长的局部反射光信号的变化，作为 选择使探针与皮肤接触的时间，能够使组织的影响最小化的时间窗口和探针适应对信号的选择，并且在时间窗口内测量的信号也用于以下计算。 从时间窗内的至少两个波长的多个时间间隔，在光源和检测器之间的多个距离中的多个局部反射率值和多个波长之间计算一组功能，校准关系 导出计算功能与生物体的葡萄糖浓度的组合，并采用校准关系，以便在以下测定中预测体液中的葡萄糖浓度。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2011206591A

公开(公告)日：2011-10-20

申请号：JP2011162533

申请日：2011-07-25

Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  JENG TZYY-WEN ,  YEH SHU-JEN

IPC: A61B5/1495 ,  A61B5/1455

Abstract: PROBLEM TO BE SOLVED: To provide a non-invasive estimation method of glucose and a non-invasive estimation device of glucose which enable the track of temperature-induced sugar decomposition in non-invasive estimation of glucose.SOLUTION: Owing to glucose metabolic change induction, glucose metabolism, and hemoglobin variant concentration change in a skin nutritional capillary, a localized reflectance optical probe which is adjusted at temperature different from skin temperature makes contact with skin. A time window for data collection which can minimize the impact of tissue-probe adaptability for a signal is selected. The change of a localized reflected light signal for various distances between a light source and a detector, various wavelengths, various degrees of contact time is measured from the skin contact of a probe for a given length of time. A function change in relation to the influence of heat stimulation for light absorption change by hemoglobin is calculated as a result of the influence of temperature for glucose metabolism. The function change in relation to the effect of heat stimulation for light attenuation change is calculated as a result of light scattering and blood flow change. The calibration relation between the combination of a function which is drawn from the signal of localized reflectance and glucose concentration is drawn. In order to predict a glucose concentration in a subject in subsequent time, measurement and the established calibration relation are used.

Abstract translation: 要解决的问题：提供葡萄糖的非侵入性估计方法和葡萄糖的非侵入性估计装置，其能够在葡萄糖的非侵入性估计中跟踪温度诱导的糖分解。解决方案：由于葡萄糖代谢变化诱导 ，葡萄糖代谢和血红蛋白变体浓度变化的皮肤营养毛细血管，在与皮肤温度不同的温度下调节的局部反射光学探针与皮肤接触。 选择可以最小化组织探针对信号的适应性的影响的用于数据收集的时间窗口。 根据探针的皮肤接触测量给定时间长度，测量光源和检测器之间各种距离的局部反射光信号的变化，各种波长，各种接触时间的程度。 作为葡萄糖代谢温度的影响的结果，计算出与热刺激对血红蛋白的光吸收变化的影响有关的功能变化。 作为光散射和血流变化的结果，计算与热刺激对光衰减变化的影响相关的功能变化。 绘制从局部反射信号和葡萄糖浓度之间的函数的组合之间的校准关系。 为了在随后的时间内预测受试者中的葡萄糖浓度，使用测量和建立的校准关系。

公开(公告)号：JP2012231791A

公开(公告)日：2012-11-29

申请号：JP2012128624

申请日：2012-06-06

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： CLEMENS JOHN M ,  SHAIN ERIC B ,  JENG TZYY-WEN ,  SCHNEIDER GEORGE J

IPC: C12Q1/68

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2545/101 ,  C12Q2537/165

Abstract: PROBLEM TO BE SOLVED: To provide an information system performing measurements regarding to chemical and or biological reaction, and a method using the same.SOLUTION: There are provided a method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate a portion of the analysis comprising mathematical or graphical analysis of an amplification reaction. The amount of the target present in the test sample can be objectively quantified without calculating variable threshold values and Ct values. The information usable in determining the degree of inhibition in the reaction can be obtained by the shape analysis of the PCR amplification curve of the data in cycles after Ct, etc., which are ignored before.

Abstract translation: 要解决的问题：提供对化学和/或生物反应进行测量的信息系统及其使用方法。 解决方案：提供了用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使分析的一部分自动化，包括数学或图形分析 扩增反应。 可以客观量化测试样本中存在的目标量，而不需要计算可变阈值和Ct值。 用于确定反应抑制程度的信息可以通过以下忽略的Ct等之后的循环数据的PCR扩增曲线的形状分析来获得。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2000329761A

公开(公告)日：2000-11-30

申请号：JP2000116527

申请日：2000-04-18

Applicant: ABBOTT LAB

Inventor： AUNET DIANE L ,  ELMORE KRISTIN D ,  GEORGEVICH GRADIMIR G ,  JENG TZYY-WEN ,  OOSTA GARY M ,  TERRY A PREY ,  SIEGEL NEAL A ,  KATHY R SILVERMAN

IPC: G01N33/48 ,  B01D39/00 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  B01L3/00 ,  C12M1/12 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/44 ,  C12Q1/48 ,  G01N33/49 ,  G01N33/52 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To obtain an improved system for separating a plasma or a serum from a whole blood by constituting of a matrix of a hydrophilic sintered porous substance associated with at least one type of red blood cell coagulant. SOLUTION: The system 10 comprises a housing 12 having an inlet 13 and an outlet hole 16. A device 17 is placed in the housing 12 and the device 17 contains a porous polyethylene matrix 18. The matrix contains a coagulant and is formed in a cylindrical state having a diameter of 3.5 mm and a height of 5 mm. Accurate shape and size give an influence to a retaining time and an efficiency. A paper matrix 20 is placed in the housing 12. The matrix 18 has an inlet 14 and an outlet 15 and has a liquid receiving relation to the matrix 20. The matrix 20 and the matrix 18 may contain a reagent necessary for analyzing a selected object to be analyzed for the blood.

公开(公告)号：JPH11230963A

公开(公告)日：1999-08-27

申请号：JP34170398

申请日：1998-12-01

Applicant: ABBOTT LAB

Inventor： AUNET DIANE L ,  ELMORE KRISTIN D ,  GEORGEVICH GRADIMIR G ,  JENG TZYY-WEN ,  OOSTA GARY M ,  TERRY A PREY ,  SIEGEL NEAL A ,  KATHY R SILVERMAN

IPC: G01N33/48 ,  B01D39/00 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  B01L3/00 ,  C12M1/12 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/44 ,  C12Q1/48 ,  G01N33/49 ,  G01N33/52 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To obtain an apparatus in which serum or plasma is separated quickly from whole blood while the serum or the plasma in a minimum amount is being held in the gap of a matrix by a method wherein the matrix has a pore diameter selected in such a way that individual red corpuscles are passed and that aggregated red corpuscles are held. SOLUTION: An apparatus is composed of a matrix for a hydrophilic sintered porous substance in which at least one kind of a red corpuscle flocculant is built. The matrix has a pore diameter selected in such a way that individual red corpuscles are passed through the matrix and that aggregated cells are held by the matrix. The apparatus quickly separates serum or plasma from whole blood while only the serum or the plasma in a minimum residual amount is being held inside the gap of the porus substance. The pore diameter of the matrix is selected in such a way that substantially all red corpuscles existing in the whole blood are aggregated so as to be held in the matrix by taking into consideration the length and the volume of the matrix, the volume of a blood sample to be treated and a cabability by which the flocculant aggregates the red corpuscles.

公开(公告)号：WO2005062040A3

公开(公告)日：2006-03-30

申请号：PCT/US2004038298

申请日：2004-11-17

Applicant: ABBOTT LAB ,  CLEMENS JOHN M ,  SHAIN ERIC B ,  JENG TZYY-WEN ,  SCHNEIDER GEORGE J

Inventor： CLEMENS JOHN M ,  SHAIN ERIC B ,  JENG TZYY-WEN ,  SCHNEIDER GEORGE J

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2545/101 ,  C12Q2537/165

Abstract: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.

Abstract translation: 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。

公开(公告)号：WO0187151A3

公开(公告)日：2002-05-30

申请号：PCT/US0114542

申请日：2001-05-07

Applicant: ABBOTT LAB

Inventor： KHALIL OMAR S ,  WU XIAOMAO ,  YEH SHU-JEN ,  HANNA CHARLES F ,  KANTOR STANISLAW ,  JENG TZYY-WEN

IPC: G01N21/01 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/47 ,  H01L29/04

CPC classification number: G01N21/4795 ,  A61B5/0059 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1491 ,  A61B5/6824 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043

Abstract: A method for the determination of hemoglobin and hematocrit by means of an apparatus that is capable of controlling the temperature of a defined subcutaneous volume of human skin. The method involves a calculation of hemoglobin concentration and hematocrit value that takes into consideration the values of optical parameters of the sample at various pre-set temperatures. It employs steady state optical measurements of samples, such as, for example, human tissue, by means of a reflectance tissue photometer and localized control of the temperature of the sample. An optical signal from a defined subcutaneous volume of human skin is measured as the temperature of this volume is controlled. This allows determination of hemoglobin concentration and hematocrit value non-invasively in a population of subjects having different skin colors by means of steady state reflectance measurements. The determination of hemoglobin concentration and hematocrit value is useful for monitoring patients, testing at the point of care, and screening for anemia. This method has the advantage for the determination of analytes in weak cardiac pulse situations, such as, for example, in elderly patients.

Abstract translation: 用于通过能够控制人皮肤的规定的皮下体积的温度的装置来测定血红蛋白和血细胞比容的方法。 该方法涉及在各种预设温度下考虑样品的光学参数的值的血红蛋白浓度和血细胞比容值的计算。 它采用样品（例如人体组织）通过反射组织光度计进行稳态光学测量，并对样品的温度进行局部控制。 当控制该体积的温度时，测量来自人体皮肤的确定的皮下体积的光学信号。 这允许通过稳态反射测量在具有不同皮肤颜色的受试者群体中非侵入性地测定血红蛋白浓度和血细胞比容值。 血红蛋白浓度和血细胞比容值的测定对于监测患者，在护理点进行测试和筛查贫血是有用的。 该方法具有测定弱心脏脉搏情况下的分析物的优点，例如老年患者。

公开(公告)号：WO0013002A3

公开(公告)日：2001-02-22

申请号：PCT/US9919532

申请日：1999-08-27

Applicant: ABBOTT LAB

Inventor： JENG TZYY-WEN ,  MC DOWELL LARRY L ,  PEZZANITI JOSEPH L ,  OOSTA GARY M ,  SHAIN ERIC B

IPC: G01N21/64 ,  G01N21/05 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/41 ,  G01N21/65 ,  G01N33/483 ,  G01N33/493 ,  B01L3/14

CPC classification number: G01N21/4133 ,  G01N21/05 ,  G01N21/274 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/147777 ,  Y10T436/171538 ,  Y10T436/200833

Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.

Abstract translation: 用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

公开(公告)号：CA2380243A1

公开(公告)日：2001-02-08

申请号：CA2380243

申请日：2000-07-28

Applicant: ABBOTT LAB

Inventor： HANNA CHARLES F ,  KANTOR STANISLAW ,  KHALIL OMAR S ,  WU XIAOMAO ,  YEH SHU-JEN ,  JENG TZYY-WEN

IPC: G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/35 ,  G01N21/49 ,  G01N21/31

Abstract: A method and apparatus for the measurement of trans-cutaneous diffuse reflectance at a single sampling distance for determining the concentration of an analyte in a biological sample, such as, for example, human tissue. The determination of the concentration of the analyte has been found to depend o n the sampling distance and reaches an optimal result at a defined sampling distance for a given analyte and a given sample. The method involves measuri ng the light re-emitted from the sample at a distance from a light introduction site and correlating the intensity of the re-emitted light to the concentration of an analyte. For a given sample, the distance between the light collection site and a light introduction site (i.e., the sampling distance) corresponds to the depth from the surface into the sample at which scattering and absorption events significantly affect the intensity of re- emitted light (i.e., the sampling depth). Prior knowledge about the sample determines the optimal sampling depth for performing a measurement for a specific analyte and the corresponding sampling distance needed to reach tha t optimal sampling depth. Optimization of the sampling distance, as well as th e correlation relationship, can be established in a calibration procedure.

公开(公告)号：CA2341538A1

公开(公告)日：2000-03-09

申请号：CA2341538

申请日：1999-08-27

Applicant: ABBOTT LAB

Inventor： PEZZANITI JOSEPH L ,  MCDOWELL LARRY L ,  JENG TZYY-WEN ,  SHAIN ERIC B ,  OOSTA GARY M

IPC: G01N21/64 ,  G01N21/05 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/41 ,  G01N21/65 ,  G01N33/483 ,  G01N33/493 ,  B01L3/14

Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements ca n be used to quantify the concentrations of one or more analytes in a biologic al sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement o f parameters of analytes in a biological sample. The invention also provides a n apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.