公开(公告)号：AU4416389A

公开(公告)日：1990-05-01

申请号：AU4416389

申请日：1989-10-03

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  BOYD STEVEN A ,  KEMPE DALE J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07D211/48

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.