公开(公告)号：WO0010998A3

公开(公告)日：2000-05-18

申请号：PCT/US9918229

申请日：1999-08-11

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K ,  ARMIGER YOEK-LIN ,  OR YAT SUN

IPC: C07D471/04 ,  C07D455/02 ,  A61K31/4375 ,  A61P31/04

CPC classification number: C07D471/04

Abstract: Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

Abstract translation: 具有式（I）的抗菌化合物及其药学上可接受的盐，酯和酰胺，以及含有这些化合物的药物组合物及其在治疗细菌感染中的用途。

公开(公告)号：DK59991A

公开(公告)日：1991-04-04

申请号：DK59991

申请日：1991-04-04

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  BOYD STEVEN A ,  KEMPF DALE J ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07C237/20 ,  C07D205/04 ,  C07D233/64 ,  C07D295/182 ,  C07D405/12 ,  C07K5/06

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：AU5477399A

公开(公告)日：2000-03-14

申请号：AU5477399

申请日：1999-08-11

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K ,  ARMIGER YOEK-LIN ,  OR YAT SUN

IPC: C07D471/04 ,  C07D471/00

公开(公告)号：DK59991D0

公开(公告)日：1991-04-04

申请号：DK59991

申请日：1991-04-04

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  BOYD STEVEN A ,  KEMPF DALE J ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07C237/20 ,  C07D205/04 ,  C07D233/64 ,  C07D295/182 ,  C07D405/12 ,  C07K5/06

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：AU4416389A

公开(公告)日：1990-05-01

申请号：AU4416389

申请日：1989-10-03

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  BOYD STEVEN A ,  KEMPE DALE J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07D211/48

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：CA1337909C

公开(公告)日：1996-01-09

申请号：CA615201

申请日：1989-09-29

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  PLATTNER JACOB J ,  BAKER WILLIAM R ,  BOYD STEVEN A ,  ARMIGER YOEK-LIN ,  KEMPF DALE J ,  ROSENBERG SAUL H ,  SHAM HING LEUNG ,  DE BISWANATH ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：NZ230894A

公开(公告)日：1991-07-26

申请号：NZ23089489

申请日：1989-10-04

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  PLATTNER JACOB J ,  BAKER WILLIAM R ,  BOYD STEPHEN A ,  ARMIGER YOEK-LIN ,  KEMPF DALE J ,  ROSENBERG SAUL H ,  HING LEUNG SHAM ,  DE BISWANATH ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07D405/12 ,  C07D265/30 ,  C07D205/04 ,  C07D207/10 ,  C07D211/48 ,  C07D307/16 ,  C07D317/04 ,  C07D317/14 ,  C07K5/06 ,  C07C215/08 ,  C07C215/12 ,  C07C215/14 ,  C07C229/10 ,  C07C237/06 ,  C07C237/10 ,  C07C237/12 ,  C07C237/14 ,  C07C307/02 ,  C07C311/05 ,  C07C317/24 ,  C07C317/26 ,  C07F7/02 ,  C07F9/22 ,  A61K31/535

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.