公开(公告)号：JP2009035560A

公开(公告)日：2009-02-19

申请号：JP2008211071

申请日：2008-08-19

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： PATRICIA A OLIVER ,  ARTHUR J COOPER ,  LALLAMAN JOHN E ,  LANDGRIDGE DENTON C ,  TIEN JIEH-HEH J

IPC: C07D277/28 ,  C07D277/30

CPC classification number: C07D277/28

Abstract: PROBLEM TO BE SOLVED: To provide a new process for producing an N-((N-methyl-N-((2-isopropyl-4-thyazolyl)methyl)amino)carbonyl)-amino acid derivative.
SOLUTION: The process comprises a reaction of an N-phenoxycarbonyl-L-valine with an N-methyl-N-((2-isopropyl-4-thyazolyl)methyl)amine at room temperature in THF.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供制备N - （（N-甲基-N - （（2-异丙基-4-甲唑基）甲基）氨基）羰基） - 氨基酸衍生物的新方法。 解决方案：该方法包括在室温下在THF中N-苯氧基羰基-L-缬氨酸与N-甲基-N - （（2-异丙基-4-甲唑基）甲基）胺的反应。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：WO0177134A2

公开(公告)日：2001-10-18

申请号：PCT/US0108842

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  PREMCHANDRAN RAMIYA ,  WAYNE GREGORY S ,  CHANG SOU-JEN ,  PEASE JONATHAN P ,  BHAGAVATULA LAKSHMI ,  LALLAMAN JOHN E ,  MORTON HOWARD E ,  KING STEVEN A

IPC: C07H17/08 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04 ,  C07H17/00

CPC classification number: C07D407/14

Abstract: Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

Abstract translation: 本文公开了一种制备在6-O-位含有任选取代的炔丙基的红霉素衍生物或其药学上可接受的盐的方法。

公开(公告)号：CA2403026A1

公开(公告)日：2001-10-18

申请号：CA2403026

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  KING STEVEN A ,  CHANG SOU-JEN ,  WAYNE GREGORY S ,  PEASE JONATHAN P ,  PREMCHANDRAN RAMIYA ,  LALLAMAN JOHN E ,  MORTON HOWARD E ,  BHAGAVATULA LAKSHMI

IPC: C07H17/08 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04 ,  A61K31/7048

Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

公开(公告)号：CA2229788A1

公开(公告)日：1998-01-08

申请号：CA2229788

申请日：1997-05-19

Applicant: ABBOTT LAB

Inventor： COOPER ARTHUR J ,  LALLAMAN JOHN E ,  LANGRIDGE DENTON C ,  TIEN JIEH-HEH J ,  OLIVER PATRICIA A

IPC: C07D277/28 ,  C07D277/30

Abstract: A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

公开(公告)号：PT854872E

公开(公告)日：2002-09-30

申请号：PT97923661

申请日：1997-05-19

Applicant: ABBOTT LAB

Inventor： COOPER ARTHUR J ,  TIEN JIEN-HEH J ,  LANGRIDGE DENTON ,  OLIVER PATRICIA A ,  LALLAMAN JOHN E

IPC: C07D277/28 ,  C07D277/30

Abstract: A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

公开(公告)号：CA2403026C

公开(公告)日：2007-09-25

申请号：CA2403026

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： MORTON HOWARD E ,  PEASE JONATHAN P ,  KERDESKY FRANCIS A J ,  KING STEVEN A ,  BHAGAVATULA LAKSHMI ,  LALLAMAN JOHN E ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  WAYNE GREGORY S

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04

Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O- position.

公开(公告)号：MX9801636A

公开(公告)日：1998-05-31

申请号：MX9801636

申请日：1997-05-19

Applicant: ABBOTT LAB

Inventor： OLIVER PATRICIA A ,  COOPER ARTHUR J ,  LALLAMAN JOHN E ,  LANDGRIDGE DENTON C ,  TIEN JIEH-HEH J JR

IPC: C07D277/28 ,  C07D277/30

Abstract: Se describe un procedimiento para la preparacion de derivados de N-((N-metil-N-((2-isopropil-4-tiazolil)metil)amino )carbonil)-amino ácido.

公开(公告)号：ES2177980T3

公开(公告)日：2002-12-16

申请号：ES97923661

申请日：1997-05-19

Applicant: ABBOTT LAB

Inventor： OLIVER PATRICIA A ,  COOPER ARTHUR J ,  LALLAMAN JOHN E ,  LANDGRIDGE DENTON C ,  TIEN JIEH-HEH J

IPC: C07D277/28 ,  C07D277/30

Abstract: A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

公开(公告)号：AT215535T

公开(公告)日：2002-04-15

申请号：AT97923661

申请日：1997-05-19

Applicant: ABBOTT LAB

Inventor： OLIVER PATRICIA A ,  COOPER ARTHUR J ,  LALLAMAN JOHN E ,  LANDGRIDGE DENTON C ,  TIEN JIEH-HEH J

IPC: C07D277/28 ,  C07D277/30

Abstract: A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

公开(公告)号：CA2395169A1

公开(公告)日：2001-06-28

申请号：CA2395169

申请日：2000-12-20

Applicant: ABBOTT LAB

Inventor： WAYNE GREGORY S ,  LALLAMAN JOHN E ,  HAIGHT ANTHONY R

IPC: C07B61/00 ,  C07C69/003 ,  C07C69/76 ,  C07C309/66 ,  C07D205/04 ,  C07C69/78

Abstract: A process for preparing chiral isomers of N-protected 2-azetidinemethanol compounds of formula (5), particularly N-(phenylmethyl)-2-azetidinemethanol and N-BOC-2-azetidinemethanol, and especially the (R)-isomers thereof, as we ll as O-substituted derivatives thereof.