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公开(公告)号：JP2006206597A
公开(公告)日：2006-08-10
申请号：JP2006052376
申请日：2006-02-28
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： STUK TIMOTHY L , KERDESKY FRANCIS A J , LIJEWSKI LINDA M , NORBECK DANIEL W , SCARPETTI DAVID , TIEN JIEN-HEH J , ALLEN MICHAEL S , LANGRIDGE DENTON C , MELCHER LAURA , RENO DANIEL S , SHAM HING LEUNG , ZHAO CHEN , HAIGHT ANTHONY R , LEANNA M ROBERT , MORTON HOWARD E , ROBBINS TIMOTHY A , SOWIN THOMAS J
IPC: C07C215/28 , C07B61/00 , C07C213/00 , C07C225/14 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/38 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14
CPC classification number: C07D221/14 , C07B2200/07 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07C215/08
Abstract: PROBLEM TO BE SOLVED: To provide a substituted 2,5-diamino-3-hydroxyhexane useful for producing HIV protease inhibitors, and to provide a method for producing the compound.
SOLUTION: The substituted 2,5-diamino-3-hydroxyhexane useful for producing HIV protease inhibitors is represented by general formula I.
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 待解决的问题：提供可用于产生HIV蛋白酶抑制剂的取代的2,5-二氨基-3-羟基己烷，并提供一种生产该化合物的方法。 解决方案：用于生产HIV蛋白酶抑制剂的取代的2,5-二氨基-3-羟基己烷由通式I表示。（C）2006，JPO和NCIPI
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2.发明申请
公开(公告)号：WO0177134A2
公开(公告)日：2001-10-18
申请号：PCT/US0108842
申请日：2001-03-20
Applicant: ABBOTT LAB
Inventor： KERDESKY FRANCIS A J , PREMCHANDRAN RAMIYA , WAYNE GREGORY S , CHANG SOU-JEN , PEASE JONATHAN P , BHAGAVATULA LAKSHMI , LALLAMAN JOHN E , MORTON HOWARD E , KING STEVEN A
IPC: C07H17/08 , A61P31/04 , C07B61/00 , C07D407/14 , C07D409/04 , C07D498/04 , C07H17/00
CPC classification number: C07D407/14
Abstract: Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.
Abstract translation: 本文公开了一种制备在6-O-位含有任选取代的炔丙基的红霉素衍生物或其药学上可接受的盐的方法。
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公开(公告)号：WO0224648A3
公开(公告)日：2002-06-13
申请号：PCT/US0129408
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： GUPTA ASHOK K , KING STEVEN A , LEE ELAINE C , MORTON HOWARD E , PLATA DANIEL J , PU YU-MING , SHARMA PADAM N
IPC: C07D209/08
CPC classification number: C07D209/08
Abstract: The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors, comprising the reaction of 1-formyl indoline with clorosulfonic acid and thionyl chloride, followed by reaction with an aromatic amine.
Abstract translation: 本发明公开了一种合成取代的吲哚细胞增殖抑制剂的方法，其包括1-甲酰基二氢吲哚与氯磺酸和亚硫酰氯的反应，然后与芳族胺反应。
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4.发明申请
公开(公告)号：WO0078773A3
公开(公告)日：2001-02-22
申请号：PCT/US0016579
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
Abstract translation: 一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，包括在钯催化剂和膦存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。 另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。
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公开(公告)号：DK1272500T3
公开(公告)日：2005-09-05
申请号：DK00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , COOPER ARTHUR J , HAIGHT ANTHONY R , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , GRIEME TIM , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RILEY DAVID , WITTENBERGER STEVEN J
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Patent Agency Ranking
公开(公告)号：CA2174000C
公开(公告)日：2005-05-24
申请号：CA2174000
申请日：1994-09-26
Applicant: ABBOTT LAB
Inventor： STUK TIMOTHY L , KERDESKY FRANCIS A J , LIJEWSKI LINDA M , NORBECK DANIEL W , SCARPETTI DAVID , TIEN JIEN-HEH J , ALLEN MICHAEL S , LANGRIDGE DENTON C , MELCHER LAURA , RENO DANIEL S , SHAM HING LEUNG , ZHAO CHEN , HAIGHT ANTHONY R , LEANNA M ROBERT , MORTON HOWARD E , ROBBINS TIMOTHY A , SOWIN THOMAS J
IPC: C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C233/36 , C07C217/58 , C07C233/78
Abstract: Intermediates and processes are disclosed which are useful for the preparati on of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd a nd Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected fr om loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken togethe r with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independent ly selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
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公开(公告)号：HK1053659A1
公开(公告)日：2003-10-31
申请号：HK03104301
申请日：2003-06-16
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：CA2174000A1
公开(公告)日：1995-04-27
申请号：CA2174000
申请日：1994-09-26
Applicant: ABBOTT LAB
Inventor： STUK TIMOTHY L , KERDESKY FRANCIS A J , LIJEWSKI LINDA M , NORBECK DANIEL W , SCARPETTI DAVID , TIEN JIEN-HEH J , ALLEN MICHAEL S , LANGDRIDGE DENTON C , MELCHER LAURA , RENO DANIEL S , SHAM HING LEUNG , ZHAO CHEN , HAIGHT ANTHONY R , LEANNA M ROBERT , MORTON HOWARD E , ROBBINS TIMOTHY A , SOWIN THOMAS J
IPC: C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C233/36 , C07C217/58 , C07C233/78
Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
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公开(公告)号：DE60019976T2
公开(公告)日：2006-02-16
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：AU779219B2
公开(公告)日：2005-01-13
申请号：AU5742900
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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