公开(公告)号：WO0177134A2

公开(公告)日：2001-10-18

申请号：PCT/US0108842

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  PREMCHANDRAN RAMIYA ,  WAYNE GREGORY S ,  CHANG SOU-JEN ,  PEASE JONATHAN P ,  BHAGAVATULA LAKSHMI ,  LALLAMAN JOHN E ,  MORTON HOWARD E ,  KING STEVEN A

IPC: C07H17/08 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04 ,  C07H17/00

CPC classification number: C07D407/14

Abstract: Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

Abstract translation: 本文公开了一种制备在6-O-位含有任选取代的炔丙基的红霉素衍生物或其药学上可接受的盐的方法。

公开(公告)号：WO9834917A3

公开(公告)日：1999-01-14

申请号：PCT/US9802439

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： LEANNA M ROBERT ,  HANNICK STEVEN M ,  RASMUSSEN MICHAEL ,  TIEN JIEN-HEH J ,  BHAGAVATULA LAKSHMI ,  SINGAM PULLA REDDY ,  GATES BRADLEY D ,  KOLACZKOWSKI LAWRENCE ,  PATEL RAMESH R ,  WAYNE GREG ,  LANNOYE GREG ,  ZHANG WEIJIANG ,  TIAN ZHENPING ,  LUKIN KIRILL L ,  NARAYANAN BIKSHANDARKOR A ,  RILEY DAVID A ,  MORTON HOWARD ,  CHANG SOU-JEN

IPC: C12P7/62 ,  A61K31/52 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  C07C69/16 ,  C07C309/73 ,  C07D473/18 ,  C07D473/40 ,  C07D73/00

CPC classification number: C07D473/18

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

公开(公告)号：CA2403026A1

公开(公告)日：2001-10-18

申请号：CA2403026

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  KING STEVEN A ,  CHANG SOU-JEN ,  WAYNE GREGORY S ,  PEASE JONATHAN P ,  PREMCHANDRAN RAMIYA ,  LALLAMAN JOHN E ,  MORTON HOWARD E ,  BHAGAVATULA LAKSHMI

IPC: C07H17/08 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04 ,  A61K31/7048

Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

公开(公告)号：MX2009000767A

公开(公告)日：2009-01-28

申请号：MX2009000767

申请日：2007-07-19

Applicant: ABBOTT LAB

Inventor： WITTENBERGER STEVEN J ,  FICKES MICHAEL G ,  MCDERMOTT TODD S ,  WAGAW SEBLE H ,  ENGSTROM KENNETH M ,  GANDARILLA JORGE ,  KRUGER ALBERT ,  ROZEMA MICHAEL J ,  BHAGAVATULA LAKSHMI ,  BORCHARDT THOMAS B

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

Abstract: Se describe un proceso para hacer (2S,5R)-5-etinil-1-{N-(4-metil-1 -(4-carboxi-piridin-2-il)piperidin-4-il)glicil}pirrolidina-2-carb onitrilo y sales del mismo, y los intermediarios usados en el proceso.

公开(公告)号：CA2403026C

公开(公告)日：2007-09-25

申请号：CA2403026

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： MORTON HOWARD E ,  PEASE JONATHAN P ,  KERDESKY FRANCIS A J ,  KING STEVEN A ,  BHAGAVATULA LAKSHMI ,  LALLAMAN JOHN E ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  WAYNE GREGORY S

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04

Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O- position.

公开(公告)号：CA2657930A1

公开(公告)日：2008-01-24

申请号：CA2657930

申请日：2007-07-19

Applicant: ABBOTT LAB

Inventor： GANDARILLA JORGE ,  ENGSTROM KENNETH M ,  WAGAW SEBLE H ,  FICKES MICHAEL G ,  BORCHARDT THOMAS B ,  ROZEMA MICHAEL J ,  KRUGER ALBERT ,  MCDERMOTT TODD S ,  WITTENBERGER STEVEN J ,  BHAGAVATULA LAKSHMI

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

Abstract: A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridi n-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, a nd intermediates used in the process are disclosed.