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    DETERMINATION OF GLYCATED HEMOGLOBIN BY FLUORESCENCE QUENCHING
    1.
    发明公开
    DETERMINATION OF GLYCATED HEMOGLOBIN BY FLUORESCENCE QUENCHING 失效
    通过荧光检测测定糖化血红蛋白

    公开(公告)号：EP0589001A4

    公开(公告)日：1996-01-31

    申请号：EP93906278

    申请日：1993-03-03

    Applicant: ABBOTT LAB

    Inventor： BRANDT DOUGLAS R ,  BROWN WILLIAM E ,  LANE THERESA L ,  WILSON DAVID H

    IPC: G01N21/78 ,  G01N33/53 ,  G01N33/72 ,  G01N30/48

    CPC classification number: G01N33/723 ,  Y10S435/968

    Abstract: The present invention relates to the measurement of glycated hemoglobin by fluorescence quenching. The present invention uniquely involves performing two sequential fluorescent quenching measurements: one measurement of the fluorescent quenching due to total hemoglobin in the sample and a second measurement of the fluorescent quenching due to glycated hemoglobin present in the sample after the non-glycated hemoglobin is removed. Glycated hemoglobin and non-glycated hemoglobin can be separated by a variety of methods as described herein, including ion capture and solid phase separations.

    4.
    发明专利
    未知

    公开(公告)号：DE69121635T2

    公开(公告)日：1997-04-03

    申请号：DE69121635

    申请日：1991-06-03

    Applicant: ABBOTT LAB

    Inventor： GARNER WILLIAM D ,  CODACOVI LYNN MARIE ,  MATTINGLY PHILLIP GREGORY ,  WELCH CHRISTOPHER JOSEPH ,  KUEMMERLE STEVEN C ,  DELBY SUZANNE M ,  LANE THERESA L

    IPC: C12Q1/42 ,  C07K17/08 ,  G01N33/543 ,  G01N33/82 ,  G01N33/546 ,  G01N33/545

    Abstract: The current invention is a method, kit and reagents for detecting cobalamins in a sample. The method involves introducing into the sample a first conjugate of a latex or latex-like solid phase linked to affinity purified intrinsic factor with a first linking group at least three angstroms long. The first conjugate and the bound cobalamins in the sample are then exposed to a second conjugate of a cobalamin linked to a detectable enzyme to produce second conjugate bound to first conjugate and unbound second conjugate. The enzyme activity associated either with the solid phase first conjugate or the unbound second conjugate is then detected. By linking affinity purified intrinsic factor to a latex or latex-like solid phase with a first linking group at least three angstroms long, an enzyme assay can be performed which detects levels of cobalamins in patient samples within or below normal ranges found in such samples.

    10.
    发明专利
    未知

    公开(公告)号：DE69121635D1

    公开(公告)日：1996-10-02

    申请号：DE69121635

    申请日：1991-06-03

    Applicant: ABBOTT LAB

    Inventor： GARNER WILLIAM D ,  CODACOVI LYNN MARIE ,  MATTINGLY PHILLIP GREGORY ,  WELCH CHRISTOPHER JOSEPH ,  KUEMMERLE STEVEN C ,  DELBY SUZANNE M ,  LANE THERESA L

    IPC: C12Q1/42 ,  C07K17/08 ,  G01N33/543 ,  G01N33/82 ,  G01N33/546 ,  G01N33/545

    Abstract: The current invention is a method, kit and reagents for detecting cobalamins in a sample. The method involves introducing into the sample a first conjugate of a latex or latex-like solid phase linked to affinity purified intrinsic factor with a first linking group at least three angstroms long. The first conjugate and the bound cobalamins in the sample are then exposed to a second conjugate of a cobalamin linked to a detectable enzyme to produce second conjugate bound to first conjugate and unbound second conjugate. The enzyme activity associated either with the solid phase first conjugate or the unbound second conjugate is then detected. By linking affinity purified intrinsic factor to a latex or latex-like solid phase with a first linking group at least three angstroms long, an enzyme assay can be performed which detects levels of cobalamins in patient samples within or below normal ranges found in such samples.

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