公开(公告)号：BG104981A

公开(公告)日：2001-07-31

申请号：BG10498100

申请日：2000-11-24

Applicant: ABBOTT LAB

Inventor： CRAIG RICHARD A ,  HENKIN JACK ,  KAWAI MEGUMI ,  LYNCH LINDA L ,  PATEL JYOTI ,  SHEPPARD GEORGE S ,  WANG JIEYI

IPC: C07C235/16 ,  C07C237/12 ,  C07C237/14 ,  C07C311/18 ,  C07C311/19 ,  C07C323/58 ,  C07C323/60 ,  C07D207/26 ,  C07D207/27 ,  C07D209/14 ,  C07D209/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/40 ,  C07D213/74 ,  C07D213/75 ,  C07D217/06 ,  C07D231/40 ,  C07D233/76 ,  C07D233/95 ,  C07D235/14 ,  C07D241/08 ,  C07D277/46 ,  C07D277/56 ,  C07D295/185 ,  C07D307/14 ,  C07D317/58 ,  C07D317/66 ,  C07D333/20 ,  C07D333/38 ,  C07D521/00 ,  A61K31/16

Abstract: A class of substituted beta-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed. 18 claims