Patent search ap:("ABBOTT LAB") AND inv:"MARTIN YVONNE C" Page 1

1.

发明专利
DOPAMINE AGONISTS 未知

公开(公告)号：AU4751393A

公开(公告)日：1993-12-16

申请号：AU4751393

申请日：1993-09-21

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W

IPC: A61K31/135 , A61K31/35 , A61K31/40 , A61K31/535 , C07C215/52 , C07C217/60 , C07C219/28 , C07C237/08 , C07C271/16 , C07C271/44 , C07C271/58 , C07C309/65 , C07C323/60 , C07D207/08 , C07D207/16 , C07D209/44 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/96 , C07D319/20 , C07D335/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/10 , C07D493/10 , C07K5/06

2.

发明专利
ALKYLPHENYL BENZOPYRANS 未知

公开(公告)号：CA1010455A

公开(公告)日：1977-05-17

申请号：CA196455

申请日：1974-04-01

Applicant: ABBOTT LAB

Inventor： WINN MARTIN , LYNN KATHLEEN R , MARTIN YVONNE C

IPC: C07C37/055 , C07D213/30 , C07D213/50 , C07D311/80 , C07D311/94

Abstract: 1459564 Derivatives of dibenzopyran and cyclopentabenzopyran ABBOTT LABORATORIES 1 April 1974 [2 April 1973 13 Feb 1974] 14404/74 Heading C2C The invention comprises compounds of formulµ and the pharmaceutically acceptable salts of (I), (II) and (III), wherein n is 1 or 2; R and R 1 are each H or C 1-6 alkyl [but in the pyrone compound (XIII), H or Me]; R 2 is C 1-6 alkyl; Y is C 1-10 alkylene; R 4 , R 5 , R 6 are each H, halogen, CF 3 or C 1-6 alkyl; and Z is C or N. In examples, (XIII) are prepared by reacting an ethyl cyclopentanone (or cyclohexanone)-2-carboxylate with an appropriate 5-aralkylresorcinol (A), and converted into (I) and (II) by reaction with R 2 MgBr, followed optionally by hydrogenation to give (III). Starting materials prepared are the dimethyl ethers of (A), the benzene compounds where Q is CH : CHCO 2 H, CH 2 CH 2 CO 2 H, (CH 2 ) 3 OH, (CH 2 ) 3 Br, (CH 2 ) 5 OH and (CH 2 ) 3 Br, and the compounds 3,5-(MeO) 2 C 6 H 3 CR 0 R 0 - alkylene-Ar where CR 0 R 0 is CO or one R‹ is Me and the other is OH, and Ar is R 4 R 5 R 6 C 5 HZ-. Therapeutic compositions for oral, parenteral or rectal administration comprise the above compounds (Ia), which are analgesics, mild tranquillizers and antidiarrhoeals.

3.

发明专利
DOPAMINE AGONISTS 未知

公开(公告)号：GR900100423A

公开(公告)日：1991-10-10

申请号：GR90100423

申请日：1990-05-31

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W , MARTIN YVONNE C , PERNER RICHARD J , HSIAO CHI-NUNG W , DEBERNARDIS JOHN F , MEYER MICHAEL D , EHRLICH PAUL P , MORTON HOWARD E , KEBABIAN JOHN W , DENINNNO MICHAEL P , STOUT DAVID M , DIDOMENICO STANLEY JR , BASHA FATIMA Z DE

IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07C235/08 , C07C235/18 , C07C217/58 , C07C215/50 , C07C237/22

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

4.

发明专利
未知

公开(公告)号：DK0474767T3

公开(公告)日：1996-07-15

申请号：DK90909264

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： DEBERNARDIS JOHN F , DE BISWANATH , SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , BASHA FATIMA Z , MEYER MICHEAL D , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M

IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D409/04 , A01N43/00 , A01N33/00 , A61K31/395 , A61K31/235 , C07D209/56 , C07D211/00 , C07D311/74 , C07C69/76 , C07D487/00

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

5.

发明专利
Dopamine agonists 未知

公开(公告)号：AU655898B2

公开(公告)日：1995-01-12

申请号：AU4751393

申请日：1993-09-21

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W

IPC: A61K31/135 , A61K31/35 , A61K31/40 , A61K31/535 , C07C215/52 , C07C217/60 , C07C219/28 , C07C237/08 , C07C271/16 , C07C271/44 , C07C271/58 , C07C309/65 , C07C323/60 , C07D207/08 , C07D207/16 , C07D209/44 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/96 , C07D319/20 , C07D335/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/10 , C07D493/10 , C07K5/06

6.

发明专利
DOPAMINE AGONISTS 未知

公开(公告)号：AU5818290A

公开(公告)日：1991-01-07

申请号：AU5818290

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W , DEBERNARDIS JOHN F , BASHA FATIMA Z , MEYER MICHEAL D , DE BISWANATH , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M

IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D409/04 , C07D209/56 , C07D211/00 , C07C69/76 , A01N43/32 , A01N43/16 , A61K31/395 , A61K31/235 , C07D311/74 , C07D487/00 , A01N43/42 , A01N43/62 , A01N33/00

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

7.

发明专利
DOPAMINE AGONISTS 未知

公开(公告)号：CA2056995A1

公开(公告)日：1990-12-01

申请号：CA2056995

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , DEBERNARDIS JOHN F , BASHA FATIMA Z , MEYER MICHAEL D , DE BISWANATH , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M

IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D493/04 , C07D413/06 , A61K31/35 , A61K31/395 , C07D209/60

Abstract: 2056995 9015056 PCTABS00002 Novel compounds are provided of formula (I), or a pharmaceutically acceptable salt, ester or amide thereof, wherein A is O, S, CHR2, CR2 or C when n is 0 and A and R6 taken together form a nitrogen-containing 5-, 6- or 7-membered ring, and n is zero or 1. The dotted lines represent optional double bonds. R1 is selected from hydrogen and a readily cleavable group. R2 is selected from hydrogen, alkyl, substituted alkyl, alkenyl and alkynyl. R3 is selected from alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic aryl, carbocyclic arylalkyl and heterocycle. R4 is selected from hydrogen and alkyl or, taken together with R3 and the carbon atom to which they are attached, forms a spirocycloalkyl ring of from 3 to 7 carbons. R5 is selected from hydrogen, alkyl and substituted alkyl or, taken together with R3 and the carbon atoms to which they are attached forms a cycloalkyl ring of from 5 to 7 carbons. R6 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic arylalkyl, alkanoyl of from 1 to 8 carbons, amino acid and dipeptide or, taken together with A when A is C and when n is 0, forms a nitrogen-containing 5-, 6-, or 7-membered ring. R7 is hydrogen or alkyl or, taken together with R6 or R8, forms a nitrogen-containing 5-, 6- or 7-membered ring, provided that when R6 is carbocyclic arylalkyl, R7 is not alkyl. R8 is hydrogen or alkyl or, taken together with R6 or R7, forms a nitrogen-containing 5-, 6-, or 7-membered ring or, taken together with the catechol ring at the 8-position and the carbon atoms to which they are attached, forms a 5-, 6- or 7-membered ring. The compounds of the invention are useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders.