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公开(公告)号：WO9962908A3
公开(公告)日：2000-03-30
申请号：PCT/US9912419
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）的化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。
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公开(公告)号：SK18542000A3
公开(公告)日：2001-12-03
申请号：SK18542000
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：BG105109A
公开(公告)日：2001-11-30
申请号：BG10510901
申请日：2001-01-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
Abstract: Compounds having formula are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising said compounds, and methods of inhibiting/treating inflammatory diseases in a mammal. 23 claims, 1 figure
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公开(公告)号：NO20006157D0
公开(公告)日：2000-12-04
申请号：NO20006157
申请日：2000-12-04
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：AU5673196A
公开(公告)日：1996-11-21
申请号：AU5673196
申请日：1996-05-02
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROSENBERG SAUL H , FUNG K L ANTHONY , ROCKWAY TODD W , FAKHOURY STEPHEN A , GARVEY DAVID S , DONNER B GREGORY , O'CONNOR STEPHEN J , PRASAD RAJNANDAN N , SHEN WANG , STOUT DAVID M , SULLIVAN GERARD M
IPC: C07C65/24 , C07C65/28 , C07C65/40 , C07C69/94 , C07C229/38 , C07C233/22 , C07C233/65 , C07C233/69 , C07C233/73 , C07C233/87 , C07C235/16 , C07C235/34 , C07C235/42 , C07C235/48 , C07C235/60 , C07C235/84 , C07C237/08 , C07C237/20 , C07C237/32 , C07C251/48 , C07C255/57 , C07C259/10 , C07C271/48 , C07C275/42 , C07C311/08 , C07C311/29 , C07C311/51 , C07C323/59 , C07C327/48 , C07C333/04 , C07D209/16 , C07D213/40 , C07D231/12 , C07D271/10 , C07D271/113 , C07D307/88 , C07D307/89 , C07D309/32 , C07D311/68 , C07D319/06 , C07D333/20 , C07C235/38 , C07D257/04 , C07C335/22 , C07C233/12
Abstract: The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.
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Patent Agency Ranking6.发明专利
公开(公告)号：CA2218597A1
公开(公告)日：1996-10-24
申请号：CA2218597
申请日：1996-04-18
Applicant: ABBOTT LAB
Inventor： STEIN HERMAN H , FUND K L ANTHONY , AUGERI DAVID J , BAKER WILLIAM R , SULLIVAN GERARD M , ROSENBERG SAUL H , O'CONNOR STEPHEN J , FAKHOURY STEPHEN A , PRASAD RAJNANDAN N , STOUT DAVID M , SHEN WANG , ROCKWAY TODD W , MCCLELLAN WILLIAM J , GARVEY DAVIS S , ARENDSEN DAVID L
IPC: A61K31/195 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/433 , A61P3/06 , A61P9/00 , A61P9/08 , A61P31/04 , A61P35/00 , A61P43/00 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C235/82 , C07D271/06 , C07D271/10 , C07D285/10 , C07D333/20 , A61K38/04 , C07D215/14 , A61K31/16 , A61K31/19 , C07D333/24 , C07D263/32 , A61K31/33 , C07C323/40 , C07C317/44 , C07C311/45 , C07D307/54 , C07D213/56 , C07C233/57 , C07D317/60 , C07D333/60
Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
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公开(公告)号：DK0474767T3
公开(公告)日：1996-07-15
申请号：DK90909264
申请日：1990-05-22
Applicant: ABBOTT LAB
Inventor： DEBERNARDIS JOHN F , DE BISWANATH , SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , BASHA FATIMA Z , MEYER MICHEAL D , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D409/04 , A01N43/00 , A01N33/00 , A61K31/395 , A61K31/235 , C07D209/56 , C07D211/00 , C07D311/74 , C07C69/76 , C07D487/00
Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
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公开(公告)号：AU655898B2
公开(公告)日：1995-01-12
申请号：AU4751393
申请日：1993-09-21
Applicant: ABBOTT LAB
Inventor： SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W
IPC: A61K31/135 , A61K31/35 , A61K31/40 , A61K31/535 , C07C215/52 , C07C217/60 , C07C219/28 , C07C237/08 , C07C271/16 , C07C271/44 , C07C271/58 , C07C309/65 , C07C323/60 , C07D207/08 , C07D207/16 , C07D209/44 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/96 , C07D319/20 , C07D335/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/10 , C07D493/10 , C07K5/06
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公开(公告)号：AU5818290A
公开(公告)日：1991-01-07
申请号：AU5818290
申请日：1990-05-22
Applicant: ABBOTT LAB
Inventor： SCHOENLEBER ROBERT W , DEBERNARDIS JOHN F , BASHA FATIMA Z , MEYER MICHEAL D , DE BISWANATH , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D409/04 , C07D209/56 , C07D211/00 , C07C69/76 , A01N43/32 , A01N43/16 , A61K31/395 , A61K31/235 , C07D311/74 , C07D487/00 , A01N43/42 , A01N43/62 , A01N33/00
Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
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公开(公告)号：CA2056995A1
公开(公告)日：1990-12-01
申请号：CA2056995
申请日：1990-05-22
Applicant: ABBOTT LAB
Inventor： SCHOENLEBER ROBERT W , KEBABIAN JOHN W , MARTIN YVONNE C , DENINNO MICHAEL P , PERNER RICHARD J , STOUT DAVID M , HSIAO CHI-NUNG W , DIDOMENICO STANLEY JR , DEBERNARDIS JOHN F , BASHA FATIMA Z , MEYER MICHAEL D , DE BISWANATH , EHRLICH PAUL P , CAMPBELL JAMES R , MORTON HOWARD E , LIJEWSKI LINDA M
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07D493/04 , C07D413/06 , A61K31/35 , A61K31/395 , C07D209/60
Abstract: 2056995 9015056 PCTABS00002 Novel compounds are provided of formula (I), or a pharmaceutically acceptable salt, ester or amide thereof, wherein A is O, S, CHR2, CR2 or C when n is 0 and A and R6 taken together form a nitrogen-containing 5-, 6- or 7-membered ring, and n is zero or 1. The dotted lines represent optional double bonds. R1 is selected from hydrogen and a readily cleavable group. R2 is selected from hydrogen, alkyl, substituted alkyl, alkenyl and alkynyl. R3 is selected from alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic aryl, carbocyclic arylalkyl and heterocycle. R4 is selected from hydrogen and alkyl or, taken together with R3 and the carbon atom to which they are attached, forms a spirocycloalkyl ring of from 3 to 7 carbons. R5 is selected from hydrogen, alkyl and substituted alkyl or, taken together with R3 and the carbon atoms to which they are attached forms a cycloalkyl ring of from 5 to 7 carbons. R6 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic arylalkyl, alkanoyl of from 1 to 8 carbons, amino acid and dipeptide or, taken together with A when A is C and when n is 0, forms a nitrogen-containing 5-, 6-, or 7-membered ring. R7 is hydrogen or alkyl or, taken together with R6 or R8, forms a nitrogen-containing 5-, 6- or 7-membered ring, provided that when R6 is carbocyclic arylalkyl, R7 is not alkyl. R8 is hydrogen or alkyl or, taken together with R6 or R7, forms a nitrogen-containing 5-, 6-, or 7-membered ring or, taken together with the catechol ring at the 8-position and the carbon atoms to which they are attached, forms a 5-, 6- or 7-membered ring. The compounds of the invention are useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders.
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