公开(公告)号：SE7413303L

公开(公告)日：1975-04-24

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：AU500839B2

公开(公告)日：1979-05-31

申请号：AU1718776

申请日：1976-08-26

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  KYNCL J

IPC: A61K31/225 ,  A61K31/235 ,  A61P9/08 ,  A61P9/12 ,  C07C237/08 ,  C07C271/22 ,  C07C103/50 ,  A61K31/215 ,  C07C125/06

Abstract: This invention covers diacylated derivatives of gamma -glutamyl dopamine selected from the group consisting of where R is a C1-C12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C1-C7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.

公开(公告)号：SE7609886A

公开(公告)日：1977-03-12

申请号：SE7609886

申请日：1976-09-07

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  KYNCL J

IPC: A61K31/225 ,  A61K31/235 ,  A61P9/08 ,  A61P9/12 ,  C07C237/08 ,  C07C271/22 ,  C07C103/50

CPC classification number: C07C271/22

公开(公告)号：AU6262680A

公开(公告)日：1981-04-16

申请号：AU6262680

申请日：1980-09-23

Applicant: ABBOTT LAB

Inventor： OURS C W ,  LEE C M

IPC: A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61P7/10 ,  C07C59/90 ,  C07C67/00 ,  C07C213/00 ,  C07C225/16 ,  C07C231/00 ,  C07C235/20 ,  C07C313/00 ,  C07C323/32 ,  C07D295/112 ,  C07C101/40 ,  C07C103/78 ,  C07C149/42 ,  C07C149/43 ,  C07D295/10

公开(公告)号：SE7609886L

公开(公告)日：1977-03-12

申请号：SE7609886

申请日：1976-09-07

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  KYNCL J

IPC: A61K31/235 ,  A61K31/225 ,  A61P9/08 ,  A61P9/12 ,  C07C237/08 ,  C07C271/22 ,  C07C103/50

Abstract: This invention covers diacylated derivatives of gamma -glutamyl dopamine selected from the group consisting of where R is a C1-C12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C1-C7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.

公开(公告)号：SE409702B

公开(公告)日：1979-09-03

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：SE407798B

公开(公告)日：1979-04-23

申请号：SE7404455

申请日：1974-04-02

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  ROTEMAN R

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/50

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

公开(公告)号：SE8006870L

公开(公告)日：1981-04-10

申请号：SE8006870

申请日：1980-10-01

Applicant: ABBOTT LAB

Inventor： OURS C W ,  LEE C M

IPC: A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61P7/10 ,  C07C59/90 ,  C07C67/00 ,  C07C213/00 ,  C07C225/16 ,  C07C231/00 ,  C07C235/20 ,  C07C313/00 ,  C07C323/32 ,  C07D295/112 ,  C07C101/78

公开(公告)号：DK552074A

公开(公告)日：1975-07-07

申请号：DK552074

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：SE7413303A

公开(公告)日：1975-04-24

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

CPC classification number: A01N37/44 ,  Y10S514/929