公开(公告)号：SE409702B

公开(公告)日：1979-09-03

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：SE407798B

公开(公告)日：1979-04-23

申请号：SE7404455

申请日：1974-04-02

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  ROTEMAN R

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/50

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

公开(公告)号：SE422685B

公开(公告)日：1982-03-22

申请号：SE7611379

申请日：1976-10-13

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：AU502420B2

公开(公告)日：1979-07-26

申请号：AU1759176

申请日：1976-09-09

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/14 ,  A61K31/495 ,  A61K31/505 ,  A61K31/55 ,  A61P9/12 ,  C07D239/84 ,  C07D239/95 ,  C07D243/00 ,  C07D243/08 ,  C07D307/14 ,  C07D405/06 ,  C07D407/14

Abstract: Described are the compounds 2[4(tetrahydro-2-furoyl)-hexahydro-1,4-diazepinyl-1]-4-amino-6,7-dimet hoxy quinazoline and pharmaceutically acceptable acid addition salts thereof. The compounds are useful as antihypertensive agents.

公开(公告)号：SE7609886L

公开(公告)日：1977-03-12

申请号：SE7609886

申请日：1976-09-07

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  KYNCL J

IPC: A61K31/235 ,  A61K31/225 ,  A61P9/08 ,  A61P9/12 ,  C07C237/08 ,  C07C271/22 ,  C07C103/50

Abstract: This invention covers diacylated derivatives of gamma -glutamyl dopamine selected from the group consisting of where R is a C1-C12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C1-C7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.

公开(公告)号：SE431208B

公开(公告)日：1984-01-23

申请号：SE8008533

申请日：1980-12-04

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：AU506347B2

公开(公告)日：1979-12-20

申请号：AU1790676

申请日：1976-09-20

Applicant: ABBOTT LAB

Inventor： JONES P H ,  BARIANA D S ,  FUNG A K L ,  MARTIN Y C ,  KYNCL J ,  LALL A

IPC: A61K31/19 ,  A61K31/41 ,  A61P9/12 ,  C07C45/46 ,  C07C45/67 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/90 ,  C07C67/00 ,  C07C205/45 ,  C07D257/04 ,  C07C59/26 ,  C07C59/25

Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.

公开(公告)号：SE7611379L

公开(公告)日：1977-04-15

申请号：SE7611379

申请日：1976-10-13

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：SE7413303L

公开(公告)日：1975-04-24

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：SE7610370L

公开(公告)日：1977-03-25

申请号：SE7610370

申请日：1976-09-17

Applicant: ABBOTT LAB

Inventor： JONES P H ,  BARIANA D S ,  FUNG A K L ,  MARTIN Y C ,  KYNCI J ,  LALL A

IPC: A61K31/41 ,  A61P9/12 ,  C07C45/46 ,  A61K31/19 ,  C07C45/67 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/90 ,  C07C67/00 ,  C07C205/45 ,  C07D257/04 ,  C07C59/26

Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.