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公开(公告)号：WO2005117543A3
公开(公告)日：2007-11-22
申请号：PCT/US2005016311
申请日：2005-05-10
Applicant: ABBOTT LAB , ELMORE STEVEN W , BRUNCKO MILAN , PARK CHEOL-MIN
Inventor： ELMORE STEVEN W , BRUNCKO MILAN , PARK CHEOL-MIN
IPC: C07D211/48 , A61K31/445 , A61K31/495 , A61P35/00 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D211/70 , C07D241/04 , C07D295/06 , C07D295/14 , C07D295/155 , C07D295/205 , C07D409/06
CPC classification number: C07D211/14 , C07D211/18 , C07D211/46 , C07D211/48 , C07D295/155 , C07D295/205 , C07D409/06
Abstract: Compounds having the formula (I) are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有式（I）的化合物是凋亡启动子。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。
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2.发明申请
公开(公告)号：WO2010065824A3
公开(公告)日：2010-10-07
申请号：PCT/US2009066722
申请日：2009-12-04
Applicant: ABBOTT LAB , BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: A61P35/00 , A61K31/496 , C07D403/12
CPC classification number: C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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3.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂
公开(公告)号：WO2011119345A2
公开(公告)日：2011-09-29
申请号：PCT/US2011027895
申请日：2011-03-10
Applicant: ABBOTT LAB , DING HONG , ELMORE STEVEN , HEXAMER LAURA , KUNZER AARON R , PARK CHEOL-MIN , SOUERS ANDREW J , SULLIVAN GERARD , WENDT MICHAEL
Inventor： DING HONG , ELMORE STEVEN , HEXAMER LAURA , KUNZER AARON R , PARK CHEOL-MIN , SOUERS ANDREW J , SULLIVAN GERARD , WENDT MICHAEL
IPC: C07D295/195 , A61K31/18 , A61K31/451 , A61K31/495 , A61P35/00 , C07C311/51 , C07D211/58
CPC classification number: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有这些化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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4.发明申请SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开作为治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂的磺酰胺衍生物
公开(公告)号：WO2010065865A3
公开(公告)日：2010-09-16
申请号：PCT/US2009066790
申请日：2009-12-04
Applicant: ABBOTT LAB , BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
CPC classification number: C07D405/12 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D417/12
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡BcI -2或BcI-xL蛋白活性的式（I）化合物，含有该化合物的组合物和治疗其中表达抗细胞凋亡Bcl-2蛋白的疾病的方法。
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公开(公告)号：WO2008131000A3
公开(公告)日：2008-12-18
申请号：PCT/US2008060472
申请日：2008-04-16
Applicant: ABBOTT LAB , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU
Inventor： ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU
IPC: C07D209/34 , A61K31/404 , A61P35/00 , C07D401/12 , C07D413/06 , C07D417/04
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.
Abstract translation: 公开了抑制抗凋亡McI-1蛋白活性的式（I）化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的McI-1蛋白的疾病的方法。
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Patent Agency Ranking6.发明专利
公开(公告)号：CA2744711C
公开(公告)日：2017-06-27
申请号：CA2744711
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
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公开(公告)号：CA2682356C
公开(公告)日：2016-06-14
申请号：CA2682356
申请日：2008-04-16
Applicant: ABBOTT LAB
Inventor： ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU , MADAR DAVID
IPC: C07D209/42 , A61K31/404 , A61P35/00 , C07D401/12 , C07D413/06 , C07D417/04
Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.
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公开(公告)号：ZA201206837B
公开(公告)日：2013-05-29
申请号：ZA201206837
申请日：2012-09-12
Applicant: ABBOTT LAB
Inventor： DING HONG , HEXAMER LAURA , PARK CHEOL-MIN , SULLIVAN GERARD , ELMORE STEVEN , KUNZER AARON R , SOUERS ANDREW J , WENDT MICHAEL
IPC: A61K20060101 , A61P20060101 , C07C20060101 , C07D20060101
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
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公开(公告)号：CR20120346A
公开(公告)日：2012-09-03
申请号：CR20120346
申请日：2012-06-25
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PETROS ANDREW M , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M , SONG XIAOHONG , PARK CHANG H , PARK CHEOL-MIN
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/14
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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公开(公告)号：ECSP12012017A
公开(公告)日：2012-08-31
申请号：ECSP12012017
申请日：2012-07-03
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , SULLIVAN GERARD M , WANG GARY , WANG XILU , MANTEI ROBERT A , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU , DING HONG , HEXAMER LAURA , MCCLELLAN WILLIAM J , PARK CHANG H , PETROS ANDREW M , HANSEN TODD M , DOHERTY GEORGE A
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/14
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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