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1.发明申请
公开(公告)号：WO2010065824A3
公开(公告)日：2010-10-07
申请号：PCT/US2009066722
申请日：2009-12-04
Applicant: ABBOTT LAB , BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: A61P35/00 , A61K31/496 , C07D403/12
CPC classification number: C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：WO0240530A3
公开(公告)日：2003-03-13
申请号：PCT/US0145693
申请日：2001-11-15
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , PETROS ANDREW M , YOON HOSUP , NETTESHEIM DAVID G
IPC: G01N33/50 , C07K14/47 , G01N33/15 , G01N33/566
CPC classification number: C07K14/4747
Abstract: Mutant peptides derived from wild-type human Bcl-2 are disclosed. Assays to identify substances which block the ability of Bcl-2 to inhibit apoptosis also are disclosed.
Abstract translation: 公开了衍生自野生型人Bcl-2的突变肽。 还公开了鉴定阻断Bcl-2抑制凋亡的能力的物质的测定。
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3.发明申请MUTANT PEPTIDES DERIVED FROM BAD AND THEIR USE TO IDENTIFY SUBSTANCES WHICH BIND TO A MEMBER OF THE BCL-2 FAMILY OF PROTEINS 审中-公开从BAD衍生的突变体及其用于识别BCL-2蛋白家族成员的物质
公开(公告)号：WO0220568A3
公开(公告)日：2002-09-26
申请号：PCT/US0127410
申请日：2001-09-04
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , MEADOWS ROBERT P , JOSEPH MARY K , OLEJNICZAK EDWARD T , PETROS ANDREW M , NETTESHEIM DAVID G , SWIFT KERRY M , MATAYOSHI EDMUND , ZHANG HAICHAO
CPC classification number: C07K14/4702
Abstract: The present invention relates to peptides derived from the wild-type human Bad peptide which bind to a member of the Bcl-2 family of proteins. The peptides of the present invention can be used in an assay to identify candidate substances which induce or promote apoptosis in cells.
Abstract translation: 本发明涉及衍生自与蛋白质Bcl-2家族成员结合的野生型人Bad肽的肽。 本发明的肽可用于测定诱导或促进细胞凋亡的候选物质。
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4.发明申请SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开作为治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂的磺酰胺衍生物
公开(公告)号：WO2010065865A3
公开(公告)日：2010-09-16
申请号：PCT/US2009066790
申请日：2009-12-04
Applicant: ABBOTT LAB , BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
CPC classification number: C07D405/12 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D417/12
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡BcI -2或BcI-xL蛋白活性的式（I）化合物，含有该化合物的组合物和治疗其中表达抗细胞凋亡Bcl-2蛋白的疾病的方法。
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公开(公告)号：WO0224636A3
公开(公告)日：2002-09-26
申请号：PCT/US0129432
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07D295/14 , C07D317/58
CPC classification number: C07D207/404 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D203/10 , C07D205/12 , C07D207/24 , C07D209/08 , C07D209/96 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/227 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D241/16 , C07D249/04 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D401/06 , C07D401/12 , C07D405/04 , C07D417/12 , C07D451/02
Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Abstract translation: 具有式（I）的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进细胞凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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Patent Agency Ranking
公开(公告)号：EP2376085A4
公开(公告)日：2012-08-15
申请号：EP09837907
申请日：2009-12-17
Applicant: GENENTECH INC , INST MEDICAL W & E HALL , ABBOTT LAB
Inventor： BAELL JONATHAN BAYLDON , BUI CHINH THIEN , COLMAN PETER , DUDLEY DANETTE A , FAIRBROTHER WAYNE J , FLYGARE JOHN A , LESSENE GUILLAUME LAURENT , NDUBAKU CHUDI , NIKOLAKOPOULOS GEORGE , RYE CARL STEVEN , SLEEBS BRAD EDMUND , SMITH BRIAN JOHN , WATSON KEITH GEOFFREY , ELMORE STEVEN W , PETROS ANDREW M , SOUERS ANDREW J , CZABOTAR PETER
IPC: A61K31/535 , C07D417/14 , C07D487/04
CPC classification number: C07D417/14 , C07D417/12 , C07D487/04
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公开(公告)号：EP2373163A4
公开(公告)日：2012-10-24
申请号：EP09837920
申请日：2009-12-17
Applicant: GENENTECH INC , INST MEDICAL W & E HALL , ABBOTT LAB
Inventor： BAELL JONATHAN BAYLDON , BUI CHINH THIEN , COLMAN PETER , CZABOTAR PETER , DUDLEY DANETTE A , FAIRBROTHER WAYNE J , FLYGARE JOHN A , LESSENE GUILLAUME LAURENT , NDUBAKU CHUDI , NIKOLAKOPOULOS GEORGE , SLEEBS BRAD EDMUND , SMITH BRIAN JOHN , WATSON KEITH GEOFFREY , ELMORE STEVEN W , HASVOLD LISA A , PETROS ANDREW M , SOUERS ANDREW J , TAO ZHI-FU , WANG LE , WANG XILU
IPC: A01N43/00 , C07D417/14 , C07D471/06 , C07D473/00 , C07D487/04 , C07D495/04 , C07D513/04 , C07D513/06
CPC classification number: C07D417/14 , C07D471/06 , C07D473/00 , C07D487/04 , C07D495/04 , C07D513/04 , C07D513/06
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公开(公告)号：HK1177202A1
公开(公告)日：2013-08-16
申请号：HK13104084
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
IPC: C07D20060101
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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9.发明专利
公开(公告)号：ECSP12012020A
公开(公告)日：2012-08-31
申请号：ECSP12012020
申请日：2012-07-03
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , SULLIVAN GERARD M , WANG GARY , WANG XILU , MANTEI ROBERT A , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , DAI YUJIA , DING HONG , HEXAMER LAURA , MCCLELLAN WILLIAM J , PARK CHANG H , PETROS ANDREW M , HANSEN TODD M , DOHERTY GEORGE A , TAO ZHI FU
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D235/06 , C07D277/24 , C07D309/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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10.发明专利
公开(公告)号：CR20120347A
公开(公告)日：2012-08-14
申请号：CR20120347
申请日：2012-06-25
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHNG , SOUERS ANDREW J , SULLIVAN GERARD , TAO ZHI-GU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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