公开(公告)号：AT442383T

公开(公告)日：2009-09-15

申请号：AT01987213

申请日：2001-11-15

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN ,  PETROS ANDREW ,  YOON HO-SUP ,  NETTESHEIM DAVID

IPC: C07K14/47 ,  G01N33/50 ,  G01N33/15 ,  G01N33/566

公开(公告)号：CA2546101C

公开(公告)日：2013-06-11

申请号：CA2546101

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  PETROS ANDREW ,  SONG XIAOHONG ,  WANG XILU ,  TU NOAH ,  WENDT MICHAEL D

IPC: C07D295/14 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/635 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.

公开(公告)号：NZ547160A

公开(公告)日：2009-11-27

申请号：NZ54716004

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  PETROS ANDREW ,  SONG XIAOHONG ,  WANG XILU ,  TU NOAH ,  WENDT MICHAEL D

IPC: A61K31/635 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds of formula (I), wherein the substituents are as defined in the specification, which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases such as bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, prostate cancer, small cell lung cancer or spleen cancer.

公开(公告)号：CA2546101A1

公开(公告)日：2005-06-02

申请号：CA2546101

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： WANG XILU ,  SONG XIAOHONG ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  LYNCH CHRISTOPHER L ,  PETROS ANDREW ,  TU NOAH ,  WENDT MICHAEL D ,  BRUNCKO MILAN ,  DING HONG ,  KUNZER AARON R ,  ELMORE STEVEN

IPC: C07D295/14 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/635 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti - apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein famil y member.

公开(公告)号：AU2004290666A1

公开(公告)日：2005-06-02

申请号：AU2004290666

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： TU NOAH ,  KUNZER AARON R ,  BRUNCKO MILAN ,  WANG XILU ,  LYNCH CHRISTOPHER L ,  DING HONG ,  MCCLELLAN WILLIAM ,  SONG XIAOHONG ,  ELMORE STEVEN ,  PETROS ANDREW ,  WENDT MICHAEL D ,  PARK CHEOL-MIN

IPC: A61K31/635 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.