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公开(公告)号：AR040278A1
公开(公告)日：2005-03-23
申请号：ARP030102178
申请日：2003-06-19
Applicant: ABBOTT LAB
Inventor： VON GELDERN THOMAS , LINK JAMES T , TU NOAH , KYM PHILIP R , RICHARDS STEVEN J , JACOBSON PEER B , BISHOP RICHARD D , GATES BRADLEY D , LAI CHUNQIU
IPC: A61K31/575 , A61K31/661 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/46 , A61P9/12 , A61P43/00 , C07J9/00 , C07J41/00 , C07J51/00
Abstract: Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) o una sal aceptable para uso farmacéutico o profármaco del mismo, donde A es un miembro seleccionado del grupo formado por -O- o -NRA donde RA es un miembro seleccionado del grupo formado por H y alquilo; R1, R2, R3, R4, R5, R6 y R7 son en forma independiente miembros seleccionados del grupo formado por H, alquilo C1-6, alquenilo, alquinilo, alcoxi, hidroxi, alcoxialquilo, hidroxialquilo, y halógeno; y R8, R9, y R10 son en forma independiente miembros seleccionados del grupo formado por H, alquilo, alquenilo, alquinilo, alcoxi, hidroxi, ciano, halógeno, y -NRBRC donde RB y RC son en forma independiente miembros seleccionados del grupo formado por H y alquilo.
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公开(公告)号：AU2003243622A1
公开(公告)日：2004-01-06
申请号：AU2003243622
申请日：2003-06-17
Applicant: ABBOTT LAB
Inventor： RICHARDS STEVEN J , JACOBSON PEER B , BISHOP RICHARD D , GATES BRADLEY D , GELDERN THOMAS W VON , LINK JAMES T , TU NOAH , KYM PHILIP R , LAI CHUNQIU
IPC: A61K31/575 , A61K31/661 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/46 , A61P9/12 , A61P43/00 , C07J9/00 , C07J41/00 , C07J51/00
Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.
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公开(公告)号：CA2546101C
公开(公告)日：2013-06-11
申请号：CA2546101
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , ELMORE STEVEN , KUNZER AARON R , LYNCH CHRISTOPHER L , MCCLELLAN WILLIAM , PARK CHEOL-MIN , PETROS ANDREW , SONG XIAOHONG , WANG XILU , TU NOAH , WENDT MICHAEL D
IPC: C07D295/14 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/635 , A61P35/00 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
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Patent Agency Ranking
公开(公告)号：UY27862A1
公开(公告)日：2004-04-30
申请号：UY27862
申请日：2003-06-20
Applicant: ABBOTT LAB
Inventor： KYM PHILIP R , JACOBSON PEER B , LINK JAMES T , LAI CHUNQIU , BISHOP RICHARD D , TU NOAH , RICHARDS STEVEN J , GATES BRADLEY D , GELDERN THOMAS W VON
IPC: A61K31/575 , A61K31/661 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/46 , A61P9/12 , A61P43/00 , C07J9/00 , C07J41/00 , C07J51/00 , A61P7/12 , A61P5/44
Abstract: Nuevos compuestos que son antagonistas selectivos del receptor de glucocorticoides en el hígado, métodos para preparar dichos compuestos, y métodos para usar tales compuestos en la regulación del metabolismo, especialmente para bajar los niveles de glucosa sérica, los niveles de insulina o los niveles de lípidos, y/o reducir el peso corporal.
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公开(公告)号：NZ547160A
公开(公告)日：2009-11-27
申请号：NZ54716004
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , ELMORE STEVEN , KUNZER AARON R , LYNCH CHRISTOPHER L , MCCLELLAN WILLIAM , PARK CHEOL-MIN , PETROS ANDREW , SONG XIAOHONG , WANG XILU , TU NOAH , WENDT MICHAEL D
IPC: A61K31/635 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61P35/00 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/14 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds of formula (I), wherein the substituents are as defined in the specification, which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases such as bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, prostate cancer, small cell lung cancer or spleen cancer.
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公开(公告)号：CA2546101A1
公开(公告)日：2005-06-02
申请号：CA2546101
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： WANG XILU , SONG XIAOHONG , MCCLELLAN WILLIAM , PARK CHEOL-MIN , LYNCH CHRISTOPHER L , PETROS ANDREW , TU NOAH , WENDT MICHAEL D , BRUNCKO MILAN , DING HONG , KUNZER AARON R , ELMORE STEVEN
IPC: C07D295/14 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/635 , A61P35/00 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti - apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein famil y member.
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公开(公告)号：AU2004290666A1
公开(公告)日：2005-06-02
申请号：AU2004290666
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： TU NOAH , KUNZER AARON R , BRUNCKO MILAN , WANG XILU , LYNCH CHRISTOPHER L , DING HONG , MCCLELLAN WILLIAM , SONG XIAOHONG , ELMORE STEVEN , PETROS ANDREW , WENDT MICHAEL D , PARK CHEOL-MIN
IPC: A61K31/635 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
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8.发明专利
公开(公告)号：UY28228A2
公开(公告)日：2004-04-30
申请号：UY28228
申请日：2004-03-11
Applicant: ABBOTT LAB
Inventor： GELDEM THOMAS W VON , KYM PHILIP R , JACOBSON PEER B , LINK JAMES T , LAI CHUNQIU , BISHOP RICHARD D , TU NOAH , RICHARDS STEVEN J , GATES BRADLEY D
IPC: A61P3/10 , C07C49/527 , C07C49/657
Abstract: Nuevos compuestos que son antagonistas selectivos del receptor glucocorticoides en el hígado, métodos para preparar dichos compuestos métodos para usar tales compuestos en la regulación del metabolismo especialmente para bajar los niveles de glucosa sérica los niveles de insulina, los niveles de lípidos, y/o reducir el peso corporal
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