公开(公告)号：JP2000159800A

公开(公告)日：2000-06-13

申请号：JP32397699

申请日：1999-11-15

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  BODNER JOHN B

IPC: A61K39/395 ,  C07K1/22 ,  C07K14/435 ,  C07K14/575 ,  C07K14/59 ,  C07K16/00 ,  C07K16/26 ,  C07K17/00 ,  C07K17/06 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To obtain a purified polyclonal anti-hCG antibody having a specificity comparable to that of a monoclonal antibody. SOLUTION: The objective antibody is produced by a anti-hCG antibody purification method consisting of (a) a process in which a hCG analyte analog immobilized on a supporting material and having a peptide sequence shown by the formula: Asp112-Pro-Arg-Phe115-Gln-Asp-Ser-Ser-Ser120-Lys-Ala-Pro-Pro- Pro125-Ser-Leu-Pro-Ser-Pro130Ser-Arg-Leu-Pro-Gly135-Pro-Pro-Asp-Thr-Pr o140-Ile- Leu-Pro-Gln-Ser145-Leu-Pro is contacted with a body fluid containing the anti- hCG antibody and the anti-hCG antibody specific for this peptide sequence is adsorbed and (b) a process for subsequently eluting the specifically adsorbed anti-hCG antibody.

公开(公告)号：DE68927283D1

公开(公告)日：1996-11-07

申请号：DE68927283

申请日：1989-07-19

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  BODNER JOHN B

IPC: A61K39/395 ,  C07K1/22 ,  C07K14/435 ,  C07K14/575 ,  C07K14/59 ,  C07K16/00 ,  C07K16/26 ,  C07K17/00 ,  C07K17/06 ,  G01N33/53 ,  B01D15/08

Abstract: An affinity column antibody purification method using a synthetic hCG analyte-analog insolubilized on a support material. The immobilized hCG analyte-analogs are peptide sequences which duplicate or mimic the determinants formed by the amino acid residues of the C-terminus peptide sequence or portions or variants thereof. The antibodies produced according to the present invention are useful in immunoassays for hCG.

公开(公告)号：DE68921360D1

公开(公告)日：1995-04-06

申请号：DE68921360

申请日：1989-03-06

Applicant: ABBOTT LAB

Inventor： HUNT JEFFREY C ,  DAWSON GEORGE J ,  SARIN VIRENDER K ,  WRAY LARRY K ,  DEVARE SUSHIL G ,  WEBBER J SCOTT ,  FALK LAWRENCE A

IPC: G01N33/569 ,  C07K16/10 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  C12N5/20

公开(公告)号：DE69013950T2

公开(公告)日：1995-03-30

申请号：DE69013950

申请日：1990-01-31

Applicant: ABBOTT LAB

Inventor： HUNT JEFFREY C ,  SARIN VIRENDER K ,  DEVARE SUSHIL ,  DESAI SURESH M ,  JOHNSON-PAEPKE JILL ,  TRIBBY ILSE INGRID E ,  CASEY JAMES M

IPC: G01N33/569 ,  C07K14/16 ,  C07K16/10 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

公开(公告)号：AU616164B2

公开(公告)日：1991-10-24

申请号：AU1052388

申请日：1987-12-03

Applicant: ABBOTT LAB

Inventor： WHITSETT JEFFREY A ,  FOX J LAWRENCE ,  PILOT-MATIAS TAMI J ,  MEUTH JOSEPH L ,  SARIN VIRENDER K

IPC: C12N15/09 ,  A61K31/70 ,  A61K35/42 ,  A61K38/00 ,  A61K38/17 ,  A61P11/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/785 ,  C07K16/00 ,  C07K16/18 ,  C12N1/20 ,  C12N5/00 ,  C12N5/10 ,  C12N9/00 ,  C12N15/72 ,  C12P21/02 ,  C12R1/19 ,  C12R1/91 ,  A61K37/02 ,  C07K7/10 ,  C12P21/08 ,  C12N15/00 ,  C12N1/21 ,  C12N15/12 ,  C07K13/00 ,  C07K7/12 ,  C07K15/12 ,  G01N33/68

Abstract: Novel, isolated, substantially pure, hydrophobic surfactant-associated proteins of 4,000-7,000 dalton simple molecular weight, SAP(Val) and SAP(Phe); multimers thereof, and substitution, addition and deletion analogs and fragments thereof are disclosed. When SAP(Val) and/or SAP(Phe) is combined with lipids, its surfactant-like property imparts to the combination significant pulmonary biophysical activity. Such a combination results in enhanced adsorption of the lipids with properties similar to that of natural pulmonary surfactant material. SAP(Val) and/or SAP(Phe) in combination with lipids is highly useful for replacing or supplementing natural pulmonary surfactant material for reducing or maintaining normal surface tension in the lungs, especially in the lungs of patients suffering from hyaline membrane disease, HMD, or other syndromes associated with the lack or insufficient amounts of natural pulmonary surfactant material. A combination of SAP(Val) and/or SAP(Phe) and lipids may be administered as an aerosol spray or in aqueous normal saline with or without calcium chloride for treating or preventing HMD and other surfactant deficiency states. Also disclosed are methods of isolating the SAP(Val) from animal tissue and methods for making SAP(Val) and SAP(Phe) by recombinant DNA techniques and direct peptide synthesis; genomic clones of SAP(Val) and SAP(Phe); expression systems and products for SAP(Val) DNA; and polyclonal and monoclonal antibodies to SAP(Val) and SAP(Phe).

公开(公告)号：ES2071626T3

公开(公告)日：1995-07-01

申请号：ES89103859

申请日：1989-03-06

Applicant: ABBOTT LAB

Inventor： HUNT JEFFREY C ,  DAWSON GEORGE J ,  SARIN VIRENDER K ,  WRAY LARRY K ,  DEVARE SUSHIL G ,  WEBBER J SCOTT ,  FALK LAWRENCE A

IPC: G01N33/569 ,  C07K16/10 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  C12N5/20

公开(公告)号：AT119203T

公开(公告)日：1995-03-15

申请号：AT89103859

申请日：1989-03-06

Applicant: ABBOTT LAB

Inventor： HUNT JEFFREY C ,  DAWSON GEORGE J ,  SARIN VIRENDER K ,  WRAY LARRY K ,  DEVARE SUSHIL G ,  WEBBER J SCOTT ,  FALK LAWRENCE A

IPC: G01N33/569 ,  C07K16/10 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  C07K1/00 ,  C07K7/00 ,  C12N5/20

公开(公告)号：AU646460B2

公开(公告)日：1994-02-24

申请号：AU7711791

申请日：1991-05-16

Applicant: ABBOTT LAB

Inventor： HUNT JEFFREY C ,  SARIN VIRENDER K ,  DEVARE SUSHIL G ,  TRIBBY ILSE INGRID E ,  DESAI SURESH M ,  CASEY JAMES M ,  JOHNSON-PAEPKE JILL

IPC: C12N5/18 ,  C12P21/08 ,  G01N33/571 ,  G01N33/577

公开(公告)号：AU7711791A

公开(公告)日：1991-09-12

申请号：AU7711791

申请日：1991-05-16

Applicant: ABBOTT LAB

Inventor： HUNT JEFFREY C ,  SARIN VIRENDER K ,  DEVARE SUSHIL G ,  TRIBBY ILSE INGRID E ,  DESAI SURESH M ,  CASEY JAMES M ,  JOHNSON-PAEPKE JILL

IPC: C12N5/18 ,  C12P21/08 ,  G01N33/571 ,  G01N33/577

公开(公告)号：AU2567888A

公开(公告)日：1989-05-25

申请号：AU2567888

申请日：1988-11-17

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  KNIGGE KEVIN M

IPC: C07K14/705 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C07K19/00 ,  C12N7/04 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/569 ,  C07K13/00 ,  G01N33/571 ,  C07K7/10 ,  C07K15/12 ,  G01N33/545 ,  G01N33/577 ,  C12N15/00 ,  A61K37/02 ,  A61K39/21

Abstract: Novel synthetic peptides which substantially replicate various sequences of gp160 envelope protein of the human immunodeficiency virus (HIV) are disclosed. Also disclosed are methods for detection of antibodies to HIV in biological samples using the gp160 peptides.