公开(公告)号：JP2005041862A

公开(公告)日：2005-02-17

申请号：JP2004176507

申请日：2004-06-15

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： SIMONS JOHN N ,  PILOT-MATIAS TAMI J ,  DAWSON GEORGE J ,  SCHLAUDER GEORGE G ,  DESAI SURESH M ,  LEARY THOMAS P ,  MUERHOFF ANTHONY SCOTT ,  ERKER JAMES CARL ,  BUIJK SHERI L ,  MUSHAHWAR ISA K

IPC: G01N33/564 ,  A61K38/00 ,  A61K39/29 ,  A61K39/395 ,  A61P1/16 ,  A61P31/12 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/08 ,  C07K14/18 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  C12R1/19 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide a non-A, non-B, non-C, non-D, non-E type hepatitis reagent, and method for using the same. SOLUTION: The nucleic aid and amino acid sequences of a hepatitis GB virus (HGBV) useful for various diagnoses and treatments, a kit for using the HGBV nucleic acid or amino acid sequence, HGBV-immunogenic particles, an antibody specifically binding with the HGBV, a method for producing a polyclonal antibody or monoclonal antibody from the HGBV nucleic acid or amino acid sequence and a method for detecting a HGBV antigen in a specimen suspected to contain the HGBV are provided. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供非A，非B，非C，非D，非E型肝炎试剂及其使用方法。 解决方案：可用于各种诊断和治疗的乙型肝炎病毒（HGBV）的核酸和氨基酸序列，使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒，特异性结合 提供HGBV，从HGBV核酸或氨基酸序列生产多克隆抗体或单克隆抗体的方法以及用于检测疑似含有HGBV的标本中的HGBV抗原的方法。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2002012600A

公开(公告)日：2002-01-15

申请号：JP2001120871

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide a highly specific and novel monoclonal antibody available for detecting a hepatitis C virus protein. SOLUTION: A monoclonal antibody not binding to hepatitis C virus C-100 protein and hepatitis C virus 33C protein and specifically binding to hepatitis C virus core protein, a hybridoma yielding the monoclonal antibody, a method for using the monoclonal antibody and an assay kit containing the antibody are provided.

公开(公告)号：JPH10337193A

公开(公告)日：1998-12-22

申请号：JP11162998

申请日：1998-03-31

Applicant: ABBOTT LAB

Inventor： SIMONS JOHN N ,  PILOT-MATIAS TAMI J ,  DAWSON GEORGE J ,  SCHLAUDER GEORGE G ,  DESAI SURESH M ,  LEARY THOMAS P ,  MUERHOFF ANTHONY SCOTT ,  ERKER JAMES CARL ,  BUIJK SHERI L ,  MUSHAHWAR ISA K

IPC: G01N33/564 ,  A61K38/00 ,  A61K39/29 ,  A61K39/395 ,  A61P1/16 ,  A61P31/12 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/08 ,  C07K14/18 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  C12R1/19 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To obtain an antibody excellent in assay accuracy ad useful for diagnostics, kits, vaccines, etc., by setting against hepatitis GB virus(HGBV) epitope(s). SOLUTION: This antibody is such one as to stand against at least one kind of Hepatitis GB virus(HGBV) epitope, being pref. a polyclonal or monoclonal antibody. This antibody is obtained by administering an individual with an isolated immunogenic polypeptide (or a fragment thereof) containing at least one HGBV epitope at an amount enough to induce immune response. Furthermore, it is preferable that a suspectable test sample containing HGBV is contacted with an antibody (fragment) specifically bindable to at least one HGBV antigen for an enough time and under sufficient conditions to form an antibody/antigen complex to detect an antibody-contg. complex to detect a HGBV antigen in the test sample.

公开(公告)号：JP2002000267A

公开(公告)日：2002-01-08

申请号：JP2001120859

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide an antibody specifically bonding generally to hepatitis C virus(HCV), more particularly, a panel of a new hybridoma cell strain secreting a monoclonal antibody against HCV protein 33C and the use of the monoclonal antibody. SOLUTION: The present invention relates to a monoclonal antibody specifically bonding to HCV protein 33C and free from bonding potency to HCV protein C-100 and a core and to a hybridoma producing the monoclonal antibody and selected from the group consisting of A.T.C.C. deposit No. HB10594, HB10589, HB10607 and HB10600. It also relates to a method for the use of the monoclonal antibody e.g. for the detection of hepatitis C virus HCV 33C protein in a specimen and an assay kit containing the antibody.

公开(公告)号：JPH11313671A

公开(公告)日：1999-11-16

申请号：JP4811199

申请日：1999-02-25

Applicant: ABBOTT LAB

Inventor： DEVARE SUSHIL G ,  CASEY JAMES M ,  DESAI SURESH M

IPC: G01N33/569 ,  A61K39/21 ,  C07K1/00 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K14/195 ,  C07K14/41 ,  C07K14/705 ,  C07K19/00 ,  C12N9/00 ,  C12N15/09 ,  C12N15/48 ,  C12P21/02 ,  C12R1/19

Abstract: PROBLEM TO BE SOLVED: To obtain an HIV transmembrane antigenic polypeptide capable of increasing the expression in heterologous expression systems and useful e.g. for the diagnosis and treatment of AIDS by including a specific amino acid sequence. SOLUTION: This HIV transmembrane antigenic polypeptide is such one as to have an amino acid sequence of formula I. This HIV transmembrane antigenic polypeptide is obtained by culturing host cells such as E. coli, transformed by a recombinant expression vector integrated with a synthetic gene having a DNA sequence of formula II and encoding the HIV transmembrane antigenic polypeptide.

公开(公告)号：JPH02273187A

公开(公告)日：1990-11-07

申请号：JP30635389

申请日：1989-11-24

Applicant: ABBOTT LAB

Inventor： DEVARE SUSHIL G ,  CASEY JAMES M ,  DESAI SURESH M

IPC: G01N33/569 ,  A61K39/21 ,  C07K1/00 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K14/195 ,  C07K14/41 ,  C07K14/705 ,  C07K19/00 ,  C12N9/00 ,  C12N15/09 ,  C12N15/48 ,  C12P21/02 ,  C12R1/19

公开(公告)号：WO9708531A3

公开(公告)日：1997-04-17

申请号：PCT/US9613171

申请日：1996-08-14

Applicant: ABBOTT LAB

Inventor： MUERHOFF ANTHONY S ,  SIMONS JOHN N ,  BIRKENMEYER LARRY ,  LEARY THOMAS P ,  ERKER JAMES C ,  DESAI SURESH M ,  MUSHAHWAR ISA K ,  CHALMERS MICHELLE ,  DAWSON GEORGE J

IPC: G01N33/566 ,  C07K14/18 ,  C12N15/09 ,  C12N15/113 ,  C12N15/86 ,  C12Q1/70 ,  G01N33/576 ,  G01N

CPC classification number: C12N15/1131 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/33 ,  C12N2770/24222 ,  C12N2840/203 ,  C12Q1/6813 ,  C12Q1/707

Abstract: The invention relates to hepatitis GB virus C. nucleic acids, more particularly to oligonucleotide probes and primers for use in the detection of genotypes of hepatitis GB virus C.

公开(公告)号：WO9520664A3

公开(公告)日：1995-12-28

申请号：PCT/US9501087

申请日：1995-01-27

Applicant: ABBOTT LAB

Inventor： WATANABE SHINICHI ,  YAMAGUCHI JULIE ,  DESAI SURESH M ,  DEVARE SUSHIL G

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61K39/395 ,  A61P31/12 ,  C07H21/04 ,  C07K14/18 ,  C07K14/47 ,  C07K16/08 ,  C07K19/00 ,  C12N15/09 ,  C12P21/02 ,  C12N15/57 ,  C12N15/62

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K14/4711 ,  C07K2319/00 ,  C12N2770/24222 ,  Y10S436/82

Abstract: Mammalian expression systems for the production of HCV E1-E2 fusion proteins. Such expression systems provide high yields of HCV proteins extracellularly, and enable the development of diagnostic, vaccine and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent.

公开(公告)号：WO9521922A3

公开(公告)日：2001-09-13

申请号：PCT/US9502118

申请日：1995-02-14

Applicant: ABBOTT LAB ,  SIMONS JOHN N ,  PILOT MATIAS TAMI J ,  DAWSON GEORGE J ,  SCHLAUDER GEORGE G ,  DESAI SURESH M ,  LEARY THOMAS P ,  MUERHOFF ANTHONY SCOTT ,  ERKER JAMES CARL ,  BUIJK SHERI L ,  MUSHAHWAR ISA K

Inventor： SIMONS JOHN N ,  PILOT-MATIAS TAMI J ,  DAWSON GEORGE J ,  SCHLAUDER GEORGE G ,  DESAI SURESH M ,  LEARY THOMAS P ,  MUERHOFF ANTHONY SCOTT ,  ERKER JAMES CARL ,  BUIJK SHERI L ,  MUSHAHWAR ISA K

IPC: A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N7/01 ,  C12N15/51 ,  C12Q1/70 ,  G01N33/576 ,  A61K39/29 ,  C12Q1/68

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C07K2319/00 ,  C12N2770/24222 ,  C12Q1/707 ,  G01N33/576

Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.

Abstract translation: 用于各种诊断和治疗应用的乙型肝炎病毒（HGBV）核酸和氨基酸序列，使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒和特异性结合HGBV的抗体。 还提供了从HGBV核酸或氨基酸序列产生抗体，多克隆或单克隆抗体的方法。

公开(公告)号：WO0046407A9

公开(公告)日：2001-09-07

申请号：PCT/US0002982

申请日：2000-02-04

Applicant: ABBOTT LAB

Inventor： LEARY THOMAS P ,  SIMONS JOHN N ,  ERKER JAMES C ,  CHALMERS MICHELE L ,  BIRKENMEYER LARRY G ,  MUERHOFF A SCOTT ,  PILOT-MATIAS TAMI J ,  DESAI SURESH M ,  MUSHAHWAR ISA K

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/566 ,  C12N15/86

CPC classification number: C12Q1/701 ,  Y10S977/804

Abstract: The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or probes. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention encompasses a method of detecting TTV infection prior to xenotransplantation of a tissue or organ.

Abstract translation: 本发明涉及用于在测试样品中检测TTV的核酸低聚物引物或探针。 还提供了利用这些引物和探针的测定法，以及含有这些寡聚体引物和/或探针的测试试剂盒。 此外，本发明包括TTV核苷酸序列作为核酸载体的用途以及用于确定个体间传播的标记及其途径。 此外，本发明包括在组织或器官的异种移植之前检测TTV感染的方法。