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公开(公告)号：JPH10337193A
公开(公告)日：1998-12-22
申请号：JP11162998
申请日：1998-03-31
Applicant: ABBOTT LAB
Inventor： SIMONS JOHN N , PILOT-MATIAS TAMI J , DAWSON GEORGE J , SCHLAUDER GEORGE G , DESAI SURESH M , LEARY THOMAS P , MUERHOFF ANTHONY SCOTT , ERKER JAMES CARL , BUIJK SHERI L , MUSHAHWAR ISA K
IPC: G01N33/564 , A61K38/00 , A61K39/29 , A61K39/395 , A61P1/16 , A61P31/12 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/08 , C07K14/18 , C07K16/10 , C12N5/10 , C12N7/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/576 , G01N33/577
Abstract: PROBLEM TO BE SOLVED: To obtain an antibody excellent in assay accuracy ad useful for diagnostics, kits, vaccines, etc., by setting against hepatitis GB virus(HGBV) epitope(s). SOLUTION: This antibody is such one as to stand against at least one kind of Hepatitis GB virus(HGBV) epitope, being pref. a polyclonal or monoclonal antibody. This antibody is obtained by administering an individual with an isolated immunogenic polypeptide (or a fragment thereof) containing at least one HGBV epitope at an amount enough to induce immune response. Furthermore, it is preferable that a suspectable test sample containing HGBV is contacted with an antibody (fragment) specifically bindable to at least one HGBV antigen for an enough time and under sufficient conditions to form an antibody/antigen complex to detect an antibody-contg. complex to detect a HGBV antigen in the test sample.
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2.发明专利Non-a, non-b, non-c, non-d, non-e type hepatitis reagent and method for using the same 有权非A型，非B型，非C型，非D型，非E型类型的HEPATITIS试剂及其使用方法
公开(公告)号：JP2005041862A
公开(公告)日：2005-02-17
申请号：JP2004176507
申请日：2004-06-15
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： SIMONS JOHN N , PILOT-MATIAS TAMI J , DAWSON GEORGE J , SCHLAUDER GEORGE G , DESAI SURESH M , LEARY THOMAS P , MUERHOFF ANTHONY SCOTT , ERKER JAMES CARL , BUIJK SHERI L , MUSHAHWAR ISA K
IPC: G01N33/564 , A61K38/00 , A61K39/29 , A61K39/395 , A61P1/16 , A61P31/12 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/08 , C07K14/18 , C07K16/10 , C12N5/10 , C12N7/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/576 , G01N33/577
Abstract: PROBLEM TO BE SOLVED: To provide a non-A, non-B, non-C, non-D, non-E type hepatitis reagent, and method for using the same. SOLUTION: The nucleic aid and amino acid sequences of a hepatitis GB virus (HGBV) useful for various diagnoses and treatments, a kit for using the HGBV nucleic acid or amino acid sequence, HGBV-immunogenic particles, an antibody specifically binding with the HGBV, a method for producing a polyclonal antibody or monoclonal antibody from the HGBV nucleic acid or amino acid sequence and a method for detecting a HGBV antigen in a specimen suspected to contain the HGBV are provided. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 要解决的问题：提供非A，非B，非C，非D，非E型肝炎试剂及其使用方法。 解决方案：可用于各种诊断和治疗的乙型肝炎病毒（HGBV）的核酸和氨基酸序列，使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒，特异性结合 提供HGBV，从HGBV核酸或氨基酸序列生产多克隆抗体或单克隆抗体的方法以及用于检测疑似含有HGBV的标本中的HGBV抗原的方法。 版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：WO2007081517A3
公开(公告)日：2007-12-21
申请号：PCT/US2006048685
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
CPC classification number: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：WO2007081517A8
公开(公告)日：2007-09-20
申请号：PCT/US2006048685
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
CPC classification number: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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5.发明申请NON-A, NON-B, NON-C, NON-D, NON-E HEPATITIS REAGENTS AND METHODS FOR THEIR USE 审中-公开NON-A，NON-B，N-C，N-D，非E型乙型肝炎试剂及其使用方法
公开(公告)号：WO9521922A3
公开(公告)日：2001-09-13
申请号：PCT/US9502118
申请日：1995-02-14
Applicant: ABBOTT LAB , SIMONS JOHN N , PILOT MATIAS TAMI J , DAWSON GEORGE J , SCHLAUDER GEORGE G , DESAI SURESH M , LEARY THOMAS P , MUERHOFF ANTHONY SCOTT , ERKER JAMES CARL , BUIJK SHERI L , MUSHAHWAR ISA K
Inventor： SIMONS JOHN N , PILOT-MATIAS TAMI J , DAWSON GEORGE J , SCHLAUDER GEORGE G , DESAI SURESH M , LEARY THOMAS P , MUERHOFF ANTHONY SCOTT , ERKER JAMES CARL , BUIJK SHERI L , MUSHAHWAR ISA K
IPC: A61K39/00 , C07K14/18 , C07K16/10 , C12N7/01 , C12N15/51 , C12Q1/70 , G01N33/576 , A61K39/29 , C12Q1/68
CPC classification number: C07K14/005 , A61K39/00 , C07K16/109 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/576
Abstract: Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
Abstract translation: 用于各种诊断和治疗应用的乙型肝炎病毒（HGBV）核酸和氨基酸序列，使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒和特异性结合HGBV的抗体。 还提供了从HGBV核酸或氨基酸序列产生抗体，多克隆或单克隆抗体的方法。
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Patent Agency Ranking
公开(公告)号：WO0046407A9
公开(公告)日：2001-09-07
申请号：PCT/US0002982
申请日：2000-02-04
Applicant: ABBOTT LAB
Inventor： LEARY THOMAS P , SIMONS JOHN N , ERKER JAMES C , CHALMERS MICHELE L , BIRKENMEYER LARRY G , MUERHOFF A SCOTT , PILOT-MATIAS TAMI J , DESAI SURESH M , MUSHAHWAR ISA K
IPC: G01N33/53 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/566 , C12N15/86
CPC classification number: C12Q1/701 , Y10S977/804
Abstract: The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or probes. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention encompasses a method of detecting TTV infection prior to xenotransplantation of a tissue or organ.
Abstract translation: 本发明涉及用于在测试样品中检测TTV的核酸低聚物引物或探针。 还提供了利用这些引物和探针的测定法，以及含有这些寡聚体引物和/或探针的测试试剂盒。 此外，本发明包括TTV核苷酸序列作为核酸载体的用途以及用于确定个体间传播的标记及其途径。 此外，本发明包括在组织或器官的异种移植之前检测TTV感染的方法。
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公开(公告)号：WO2008133753A3
公开(公告)日：2008-12-24
申请号：PCT/US2007088027
申请日：2007-12-19
Applicant: ABBOTT LAB , BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
Inventor： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
CPC classification number: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，这类化合物与其它抗病毒剂或治疗剂的共配制或共同施用，用于合成这些化合物的方法和中间体，以及使用此类化合物治疗HCV或 其他病毒感染。
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公开(公告)号：WO2007076034A3
公开(公告)日：2007-10-04
申请号：PCT/US2006049079
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：WO0046407A3
公开(公告)日：2002-05-10
申请号：PCT/US0002982
申请日：2000-02-04
Applicant: ABBOTT LAB
Inventor： LEARY THOMAS P , SIMONS JOHN N , ERKER JAMES C , CHALMERS MICHELE L , BIRKENMEYER LARRY G , MUERHOFF A SCOTT , PILOT-MATIAS TAMI J , DESAI SURESH M , MUSHAHWAR ISA K
IPC: G01N33/53 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/566 , C12N15/86
CPC classification number: C12Q1/701 , Y10S977/804
Abstract: The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or probes. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention encompasses a method of detecting TTV infection prior to xenotransplantation of a tissue or organ.
Abstract translation: 本发明涉及用于在测试样品中检测TTV的核酸低聚物引物或探针。 还提供了利用这些引物和探针的测定法，以及含有这些寡聚体引物和/或探针的测试试剂盒。 此外，本发明包括TTV核苷酸序列作为核酸载体的用途以及用于确定个体间传播的标记及其途径。 此外，本发明包括在组织或器官的异种移植之前检测TTV感染的方法。
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公开(公告)号：EP2094276A4
公开(公告)日：2011-01-05
申请号：EP07874373
申请日：2007-12-19
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
IPC: A61K31/675 , C07D487/14
CPC classification number: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
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