Patent search ap:("ABBOTT LAB") AND inv:"SHAM HING" Page 1

1.

发明专利
Cell proliferation inhibitor 审中-公开
Title translation: 细胞增殖抑制剂

公开(公告)号：JP2006188525A

公开(公告)日：2006-07-20

申请号：JP2006016490

申请日：2006-01-25

Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories

Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W

IPC: C07C311/21 , A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/29 , C07C311/37 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/32 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07C323/32 , C07D209/02 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12

CPC classification number: C07C323/29 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/46 , C07C323/20 , C07D209/08 , C07D209/30 , C07D213/69 , C07D213/70 , C07D215/38 , C07D231/56 , C07D235/06 , C07D319/18 , C07D403/12

Abstract: PROBLEM TO BE SOLVED: To provide a compound useful for treating disease condition caused by cell proliferation and a medicinal composition containing the compound and to provide a therapeutic method using the compound. SOLUTION: The present invention provides the compound (e.g. 4-methoxy-N-(3,4,5-trimethoxyphenyl)benzenesulfonamide) represented by formula (I) and the medicinal compound containing the compound and the therapeutic method using the compound. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供可用于治疗由细胞增殖引起的疾病状态的化合物和含有该化合物的药物组合物，并提供使用该化合物的治疗方法。解决方案：本发明提供由式（I）表示的化合物（例如4-甲氧基-N-（3,4,5-三甲氧基苯基）苯磺酰胺）和含该化合物的药物化合物和使用该化合物的治疗方法。版权所有（C）2006，JPO＆NCIPI

2.

发明专利
Cell proliferation inhibitor 有权
Title translation: 细胞增殖抑制剂

公开(公告)号：JP2005336195A

公开(公告)日：2005-12-08

申请号：JP2005174115

申请日：2005-06-14

Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories

Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W

IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12

CPC classification number: C07C323/29 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/46 , C07C323/20 , C07D209/08 , C07D209/30 , C07D213/69 , C07D213/70 , C07D215/38 , C07D231/56 , C07D235/06 , C07D319/18 , C07D403/12

Abstract: PROBLEM TO BE SOLVED: To provide a compound useful for treating symptoms caused or aggravated by cell proliferation, and to provide a medicinal composition containing the same. SOLUTION: This compound represented by formula (I) (L 1 is a sulfonic ester group, a sulfonamide group, or the like; R 1 is an aryl group or a heterocyclic group which may have one or more substituents; R 2 and R 6 are each H, an alkyl, an alkoxy, or the like; R 3 to R 5 are each an alkyl, an alkoxy, or the like). The medicinal composition contains the compound. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供可用于治疗由细胞增殖引起或加剧的症状的化合物，并提供含有该化合物的药物组合物。解决方案：由式（I）表示的化合物（L 1 是磺酸酯基，磺酰胺基等; R SP 1是芳基或可以具有一个或多个取代基的杂环基; R 2 SP 3和R 6 SP 6各自为H，烷基，烷氧基等; R 3 R 5和R 5各自为烷基，烷氧基等。该药物组合物含有该化合物。版权所有（C）2006，JPO＆NCIPI

3.

发明申请
NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
Title translation: 新型乙酰-CoA羧化酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用

公开(公告)号：WO2008079610A3

公开(公告)日：2008-08-14

申请号：PCT/US2007086440

申请日：2007-12-05

Applicant: ABBOTT LAB , GU YU GUI , CLARK RICHARD F , LI QUN , WEITZBERG MOSHE , SHAM HING

Inventor： GU YU GUI , CLARK RICHARD F , LI QUN , WEITZBERG MOSHE , SHAM HING

IPC: C07D277/34 , A61K31/09 , A61K31/426 , A61P3/10 , C07C43/275

CPC classification number: C07D277/34 , C07C233/18 , C07C233/22

Abstract: The present invention relates to compounds of formula (I); Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.

Abstract translation: 本发明涉及式（I）的化合物; 还提供了可用于治疗或预防代谢疾病或病症的药物组合物和方法。

4.

发明申请
NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
Title translation: 新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用

公开(公告)号：WO2007095602A3

公开(公告)日：2007-11-08

申请号：PCT/US2007062180

申请日：2007-02-15

Applicant: ABBOTT LAB , GU YU GUI , WEITZBERG MOSHE , XU XIANGDONG , CLARK RICHARD F , ZHANG TIANYUAN , LI QUN , HANSEN TODD M , SHAM HING , BEUTEL BRUCE A , CAMP HEIDI S , WANG XIAOJUN

Inventor： GU YU GUI , WEITZBERG MOSHE , XU XIANGDONG , CLARK RICHARD F , ZHANG TIANYUAN , LI QUN , HANSEN TODD M , SHAM HING , BEUTEL BRUCE A , CAMP HEIDI S , WANG XIAOJUN

IPC: C07D277/34 , A61K31/427 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14

CPC classification number: C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14

Abstract: The present invention relates to compounds of formula (I), wherein R 1 is selected from the group consisting of hydrogen, cycloalkyl, alkyl and haloalkyl; Y is selected from the group consisting of -(CR 4a R- 4b ) m -, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein m is 1, 2 or 3; Ar 3 is phenyl or monocyclic heteroaryl; wherein Ar 3 is substituted with 1, 2 or 3 or 4 substituents. Ar 1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl; Ar 2 is a monocyclic five membered heteroaryl, wherein each Ar 2 is independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of alkyl, alkenyl, halogen, -CN, -NO 2 , hydroxy, alkoxy, -NH 2 , -N(H)(alkyl), -N(alkyl) 2 . -C(O)OH, -C(O)Oalkyl, -C(O)H, -C(O)alkyl, and haloalkyl; Z is selected from the group consisting of -OR 9a , -alkylenyl-OR 9a , -NR 6 R9 9b ; and -alkylenyl-NR 6 R 9b ; which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type U diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及式（I）化合物，其中R 1选自氢，环烷基，烷基和卤代烷基; Y选自 - （CR 4a），-S（O） - ， - C（O） - ， - ，-N（H） - ， - N（烷基） - 和-S-; 其中m为1,2或3; Ar 3是苯基或单环杂芳基; 其中Ar 3 3被1,2或3或4个取代基取代。 Ar 1选自苯基和单环，五或六元杂芳基; Ar 2是单环五元杂芳基，其中每个Ar 2 2独立地是未取代的或被1或2个选自烷基，烯基，卤素， CN，-NO 2，羟基，烷氧基，-NH 2，-N（H）（烷基）， - N（烷基）。 -C（O）OH，-C（O）O烷基，-C（O）H，-C（O）烷基和卤代烷基; Z选自-OR 9a， - 亚烷基-OR 9a，-NR 6 R 9 9b，/ N >; 和 - 亚烷基-NR 6 R 9b; 其抑制乙酰辅酶A羧化酶（ACC），并且可用于预防或治疗人类的代谢综合征，U型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。

5.

发明申请
NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
Title translation: 新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用

公开(公告)号：WO2007095603A3

公开(公告)日：2008-03-13

申请号：PCT/US2007062181

申请日：2007-02-15

Applicant: ABBOTT LAB , GU YU GUI , XU XIANGDONG , WEITZBERG MOSHE , SHAM HING

Inventor： GU YU GUI , XU XIANGDONG , WEITZBERG MOSHE , SHAM HING

IPC: C07D277/34 , A61K31/426 , A61K31/427 , C07D417/04

CPC classification number: C07D277/34 , C07D417/04

Abstract: The present invention is directed to compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or combination thereof, wherein Y is selected from the group consisting of-CR x R y -, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein each of R x and R y is independently selected from the group consisting of hydrogen. alkyl, hydroxyalkyl, and haloalkyl; or R x and R y together with the carbon to which they are attached form a monocyclic cycloalkyl or heterocycle ring, Ar 1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl, Ar 3 is phenyl or monocyclic heteroaryl, wherein Ar 3 is substituted with 1, 2, 3 or 4 substituents Ar 2 is a group of formula (a), (b), (c), (d), or (e); wherein R is hydrogen, cycloalkyj, alkyl or haloalkyl, Z 1 , Z 2 , Z 3 and Z 4 are C(R 101 ), or one or two of Z 1 , Z 2 , Z 3 and Z 4 is N and the others are C(R 101 ); Z 5 , Z 6 and Z 7 are C( 102 ). or one or two of Z 5 , Z 6 and Z 7 are N, and the others are C(R 102 ), Z is selected from the group consisting of -OR 5 , -alkylenyl-OR 5 , -N(R 6 )(R 7 ) and -alkylenyI-N(R 6 )(R 7 ), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中Y选自-CR 1 x R -C（O） - ， - O - ， - N（H） - ， - N（烷基） - 和-S-; 其中R x和R y y各自独立地选自氢。烷基，羟基烷基和卤代烷基; 或R x和R y与它们所连接的碳一起形成单环环烷基或杂环，Ar 1选自由苯基和单环五元或六元杂芳基组成的基团是苯基或单环杂芳基，其中Ar 3 3被1,2,3或4个取代取代基Ar 2是式（a），（b），（c），（d）或（e）的基团。其中R是氢，环烷基，烷基或卤代烷基，Z 1，Z 2，Z 3和Z 4。是C（R 101），或Z 1，Z 2，Z 3和Z 1中的一个或两个 4是N，其余是C（R 101）; Z 5，Z 6和Z 7是C（C 102）。或Z 5，Z 6和Z 7中的一个或多个为N，其余为C（R 102） Z）选自-OR 5， - 亚烷基-OR 5，-N（R 6）（R 6） R 7）和 - 亚烷基-N（R 6 S）（R 7），其抑制乙酰辅酶A羧化酶（ACC）并且是有用的用于预防或治疗人类的代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。