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公开(公告)号：JP2006188525A
公开(公告)日：2006-07-20
申请号：JP2006016490
申请日：2006-01-25
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: C07C311/21 , A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/29 , C07C311/37 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/32 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07C323/32 , C07D209/02 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
CPC classification number: C07C323/29 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/46 , C07C323/20 , C07D209/08 , C07D209/30 , C07D213/69 , C07D213/70 , C07D215/38 , C07D231/56 , C07D235/06 , C07D319/18 , C07D403/12
Abstract: PROBLEM TO BE SOLVED: To provide a compound useful for treating disease condition caused by cell proliferation and a medicinal composition containing the compound and to provide a therapeutic method using the compound. SOLUTION: The present invention provides the compound (e.g. 4-methoxy-N-(3,4,5-trimethoxyphenyl)benzenesulfonamide) represented by formula (I) and the medicinal compound containing the compound and the therapeutic method using the compound. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 待解决的问题：提供可用于治疗由细胞增殖引起的疾病状态的化合物和含有该化合物的药物组合物，并提供使用该化合物的治疗方法。 解决方案：本发明提供由式（I）表示的化合物（例如4-甲氧基-N-（3,4,5-三甲氧基苯基）苯磺酰胺）和含该化合物的药物化合物和使用该化合物的治疗方法 。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2005336195A
公开(公告)日：2005-12-08
申请号：JP2005174115
申请日：2005-06-14
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
CPC classification number: C07C323/29 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/46 , C07C323/20 , C07D209/08 , C07D209/30 , C07D213/69 , C07D213/70 , C07D215/38 , C07D231/56 , C07D235/06 , C07D319/18 , C07D403/12
Abstract: PROBLEM TO BE SOLVED: To provide a compound useful for treating symptoms caused or aggravated by cell proliferation, and to provide a medicinal composition containing the same. SOLUTION: This compound represented by formula (I) (L 1 is a sulfonic ester group, a sulfonamide group, or the like; R 1 is an aryl group or a heterocyclic group which may have one or more substituents; R 2 and R 6 are each H, an alkyl, an alkoxy, or the like; R 3 to R 5 are each an alkyl, an alkoxy, or the like). The medicinal composition contains the compound. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 待解决的问题：提供可用于治疗由细胞增殖引起或加剧的症状的化合物，并提供含有该化合物的药物组合物。 解决方案：由式（I）表示的化合物（L
1 是磺酸酯基，磺酰胺基等; R SP 1是芳基 或可以具有一个或多个取代基的杂环基; R 2 SP 3和R 6 SP 6各自为H，烷基，烷氧基等; R 3 R 5和R 5各自为烷基，烷氧基等。 该药物组合物含有该化合物。 版权所有（C）2006，JPO＆NCIPI -
公开(公告)号：WO0181316A3
公开(公告)日：2002-05-23
申请号：PCT/US0113678
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , JENNINGS NELSON LISSA TAKA , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , A61K31/33 , C07D213/74 , C07D409/12
CPC classification number: C07D213/30 , C07D213/36 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/08 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D409/10 , C07D413/12 , C07D417/06
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
Abstract translation: 式（I）化合物或其药学上可接受的盐抑制法呢基转移酶。 公开了制备该化合物的方法，含该化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号：ZA200304270B
公开(公告)日：2004-08-30
申请号：ZA200304270
申请日：2003-05-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , HASVOLD LISA A , LI TOMGMEI , MANTEI ROBERT A , SHAM HING L , TONG YUNSONG , WANG LE , WANG WEIBO , GWALTNEY STEPHEN L II , LI QUN , LIN NAN-HORNG , ROCKWAY TODD W , SULLIVAN GERARD M , WANG GARY T , WANG XILU
IPC: A61K20060101 , A61P20060101 , C07D20060101 , C07D , A61K , A61P
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公开(公告)号：PL363637A1
公开(公告)日：2004-11-29
申请号：PL36363701
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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Patent Agency Ranking
公开(公告)号：PT1181269E
公开(公告)日：2004-07-30
申请号：PT00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： WOODS KEITH W , QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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公开(公告)号：CA2371092A1
公开(公告)日：2000-12-07
申请号：CA2371092
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： WOODS KEITH W , ROSENBERG SAUL , QUN LI , BARR KENNETH J , IMADE HOVIS M , GWALTNEY STEPHEN L II , STEINER BETH A , SHAM HING
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
Abstract: Compounds having formula (I), inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
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公开(公告)号：PT1339695E
公开(公告)日：2006-08-31
申请号：PT01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D233/00 , C07D401/00 , C07D405/00 , C07D409/00
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公开(公告)号：AT323681T
公开(公告)日：2006-05-15
申请号：AT01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：DK1181269T3
公开(公告)日：2004-07-05
申请号：DK00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W , STEINER BETH A
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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